PIRIDRONATE SODIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H10NO6P2.Na
Molecular Weight	289.0947
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].OP(O)(=O)C(CC1=CC=CC=N1)P(O)([O-])=O

InChI

InChIKey=LZNFXJFOLTVFOP-UHFFFAOYSA-M

InChI=1S/C7H11NO6P2.Na/c9-15(10,11)7(16(12,13)14)5-6-3-1-2-4-8-6;/h1-4,7H,5H2,(H2,9,10,11)(H2,12,13,14);/q;+1/p-1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9052507 | https://www.ncbi.nlm.nih.gov/pubmed/18327899 | https://apps.who.int/iris/bitstream/handle/10665/275696/WHO-EMP-RHT-TSN-2013.1-eng.pdf | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 995, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Piridronic acid is pyridinyl bisphosphonate. It is the bone calcium metabolism regulator. Piridronic acid was used for the treatment of osteoporosis. It is the human farnesyl pyrophosphate synthase inhibitor. When expressed on an actual or anticipated clinical dose basis for osteoporosis piridronic acid may have a greater potential for inducing gastric damage than do pyridinyl bisphosphonates. Piridronic acid induced significantly more antral damage than risedronate and a greater number of lesions compared to pamidronate and risedronate.

Approval Year

PubMed

Title	Date	PubMed
Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.	2008-04-10	18327899
Nonclinical model for assessing gastric effects of bisphosphonates.	1997-02	9052507

Name

Type

Language

NE 97221

Preferred Name

English

PIRIDRONATE SODIUM

Official Name

English

NE-97221

Code

English

Sodium trihydrogen [2-(2-pyridyl)ethylidene]diphosphonate

Systematic Name

English

PIRIDRONATE SODIUM [USAN]

Common Name

English

PHOSPHONIC ACID, (2-(2-PYRIDINYL)ETHYLIDENE)BIS-, MONOSODIUM SALT

Common Name

English

Code System Code Type Description

ChEMBL

CHEMBL99369