DETOMIDINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H14N2.ClH
Molecular Weight	222.714
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC1=CC=CC(CC2=CNC=N2)=C1C

InChI

InChIKey=OIWRDXKNDCJZSM-UHFFFAOYSA-N

InChI=1S/C12H14N2.ClH/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12;/h3-5,7-8H,6H2,1-2H3,(H,13,14);1H

HIDE SMILES / InChI

Description
Sources: http://equimed.com/drugs-and-medications/reference/detomidine-hydrochloride |

Detomodine hydrochloride is a sedative with analgesic properties and α2-adrenergic agonist The dose-dependent sedative and analgesic effects reduce production of excitatory neurotransmitters, thereby calming the horse, relieving abdominal pain, and facilitating bronchoscopy and other procedures. Currently, detomidine is only licensed for use in horses.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Alpha-2 adrenergic receptor 3 Target ID: CHEMBL2111338 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2984021	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: http://equimed.com/drugs-and-medications/reference/detomidine-hydrochloride	Primary		Approved 8429	Dormosedan Approved Use Unknown

PubMed

Title	Date	PubMed
Analgesic effect of butorphanol and levomethadone in detomidine sedated horses.	2001 Aug	11554491
Standing laparoscopic herniorrhaphy in stallions using cylindrical polypropylene mesh prosthesis.	2001 Jan	11191617
Comparison of detomidine and romifidine as premedicants before ketamine and halothane anesthesia in horses undergoing elective surgery.	2001 Mar	11277200
Equine thoracoscopy: normal anatomy and surgical technique.	2001 May	11352343
Sedation and chemical restraint of deer.	2002 Dec	16032278
The effects of xylazine, detomidine, acepromazine and butorphanol on equine solid phase gastric emptying rate.	2002 Jul	12358052
Incorrect dose of detomidine.	2002 Jul 15	12118575
Epidural morphine and detomidine decreases postoperative hindlimb lameness in horses after bilateral stifle arthroscopy.	2002 May-Jun	11994850
Arthroscopic removal of dorsoproximal chip fractures of the proximal phalanx in standing horses.	2002 May-Jun	11994846
Aberrations in uterine contractile patterns in mares with delayed uterine clearance after administration of detomidine and oxytocin.	2002 Sep	12212889
Chemical immobilization of captive aardvark (Orycteropus afer).	2004 Dec	15732598
[Influence of detomidine on echocardiographic function parameters and cardiac hemodynamics in horses with and without heart murmur].	2004 Mar	15060976
Use of high-power ultrasonic shears for laparoscopic ovariectomy in mares.	2004 Nov 15	15568392
Effects of alpha2-adrenergic receptor agonists on urine production in horses deprived of food and water.	2004 Oct	15524320
Overdose during chemical restraint in a black rhinoceros (Diceros bicornis).	2005 Jan	15663740
Standing sedation in African elephants (Loxodonta africana) using detomidine-butorphanol combinations.	2005 Jun	17323566
Muscle metabolic changes associated with long-term inhalation anaesthesia in the horse analysed by muscle biopsy and microdialysis techniques.	2005 Mar	15737180
The analgesic effects of intrathecal xylazine and detomidine in sheep and their antagonism with systemic atipamezole.	2005 Sep	16135211
Gait pattern of the ataxic horse compared to sedated and nonsedated horses.	2006 Aug	17402459
Effects of an alveolar recruitment maneuver on cardiovascular and respiratory parameters during total intravenous anesthesia in ponies.	2006 Jan	16426225
Effect of head position on intraocular pressure in horses.	2006 Jul	16817748
Clinical observations surrounding an increased incidence of postanesthetic myopathy in halothane-anesthetized horses.	2006 Mar	16476002
Antagonism of detomidine sedation in the horse using intravenous tolazoline or atipamezole.	2006 May	16706278
Adrenergic stimulation and blocking of hormonal secretion activity of cultured cow granulosa cells.	2006 Nov	17242478
Sedation with detomidine and acepromazine influences the endoscopic evaluation of laryngeal function in horses.	2007 Nov	18065315
A point mutation in a herpesvirus polymerase determines neuropathogenicity.	2007 Nov	17997600
Metabolism before, during and after anaesthesia in colic and healthy horses.	2007 Nov 15	18001483
Development of a composite orthopaedic pain scale in horses.	2008 Oct	18061637
Effects of dobutamine on cardiac index and arterial blood pressure in isoflurane-anaesthetized horses under clinical conditions.	2009 Aug	19614840
Analgesic effect of butorphanol in ponies following castration.	2009 Jul	19803050
Steroid hormone receptors ERalpha and PR characterised by immunohistochemistry in the mare adrenal gland.	2009 Jul 22	19624811
Effect of detomidine on visceral and somatic nociception and duodenal motility in conscious adult horses.	2009 Mar	19239655
Pharmacokinetics of detomidine administered to horses at rest and after maximal exercise.	2009 May	19642399
Plasma concentrations, behavioural and physiological effects following intravenous and intramuscular detomidine in horses.	2009 Nov	20095225
Comparison of intraoperative behavioral and hormonal responses to noxious stimuli between mares sedated with caudal epidural detomidine hydrochloride or a continuous intravenous infusion of detomidine hydrochloride for standing laparoscopic ovariectomy.	2010 Aug	20459483
Human exposures to immobilising agents: results of an online survey.	2010 Aug 28	20802186
Tachypnea and antipyresis in febrile horses after sedation with alpha-agonists.	2010 Jul-Aug	20492482
Immobilization and intravenous anesthesia in a Sumatran rhinoceros (Dicerorhinus sumatrensis).	2010 Mar	20722263
Total intravenous anesthesia with midazolam, ketamine, and xylazine or detomidine following induction with tiletamine, zolazepam, and xylazine in red deer (Cervus elaphus hippelaphus) undergoing surgery.	2010 Oct	20966270
Accidental poisoning with detomidine and butorphanol.	2010 Sep	20573843

Patents

Sample Use Guides

In Vivo Use Guide

for horses: Oral (gel): 0.04 mg/kg; Intravenous or Intramuscular injection: 0.02-0.04 mg/kg

Route of Administration: Other

In Vitro Use Guide

The sedative alpha2-adrenoceptor agonists medetomidine and detomidine inhibited aldosterone release (range 10-1000 nM). The 4-substituted imidazoles atipamezole, detomidine, and medetomidine inhibited mitochondrial cytochrome P450(11beta/18) in vitro.

Name

Type

Language

DETOMIDINE HYDROCHLORIDE

Official Name

English

DETOMIDINE HYDROCHLORIDE [MI]

Common Name

English

DETOMIDINE HYDROCHLORIDE FOR VETERINARY USE [EP MONOGRAPH]

Common Name

English

DETOMIDINE HYDROCHLORIDE [GREEN BOOK]

Common Name

English

DETOMIDINE HYDROCHLORIDE [MART.]

Common Name

English

DETOMIDINE HYDROCHLORIDE FOR VETERINARY USE

Common Name

English

1H-IMIDAZOLE, 4-((2,3-DIMETHYLPHENYL)METHYL)-, MONOHYDROCHLORIDE

Common Name

English

MPV-253 AII

Code

English

DETOMIDINE HCL

Common Name

English

DETOMIDINE HYDROCHLORIDE [USAN]

Common Name

English

4-(2,3-Dimethylbenzyl)imidazole monohydrochloride

Systematic Name

English

Classification Tree Code System Code

CFR

21 CFR 522.536