DETOMIDINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H14N2.ClH
Molecular Weight	222.714
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC1=C(C)C(CC2=CNC=N2)=CC=C1

InChI

InChIKey=OIWRDXKNDCJZSM-UHFFFAOYSA-N

InChI=1S/C12H14N2.ClH/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12;/h3-5,7-8H,6H2,1-2H3,(H,13,14);1H

HIDE SMILES / InChI

Description
Sources: http://equimed.com/drugs-and-medications/reference/detomidine-hydrochloride |

Detomodine hydrochloride is a sedative with analgesic properties and α2-adrenergic agonist The dose-dependent sedative and analgesic effects reduce production of excitatory neurotransmitters, thereby calming the horse, relieving abdominal pain, and facilitating bronchoscopy and other procedures. Currently, detomidine is only licensed for use in horses.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Alpha-2 adrenergic receptor 3 Target ID: CHEMBL2111338 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2984021	Agonist 2752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 619 Sources: http://equimed.com/drugs-and-medications/reference/detomidine-hydrochloride	Primary		Approved 8583	Dormosedan Approved Use Unknown

PubMed

Title	Date	PubMed
Analgesic effect of butorphanol and levomethadone in detomidine sedated horses.	2001 Aug	11554491
Standing laparoscopic herniorrhaphy in stallions using cylindrical polypropylene mesh prosthesis.	2001 Jan	11191617
Comparison of detomidine and romifidine as premedicants before ketamine and halothane anesthesia in horses undergoing elective surgery.	2001 Mar	11277200
Sedation and chemical restraint of deer.	2002 Dec	16032278
Comparison of etorphine-detomidine and medetomidine-ketamine anesthesia in captive addax (Addax nasomaculatus).	2003 Sep	14582789
Accidental human poisoning with a veterinary tranquilliser.	2005 Jul	15983098
In vivo effect of interleukin-1beta and interleukin-1RA on oocyte cytoplasmic maturation, ovulation, and early embryonic development in the mare.	2005 Jun 22	15972098
The analgesic effects of intrathecal xylazine and detomidine in sheep and their antagonism with systemic atipamezole.	2005 Sep	16135211
Effect of defocused CO2 laser on equine tissue perfusion.	2006	16722304
Dissociative anaesthesia during field and hospital conditions for castration of colts.	2006	16722301
The influence of alpha-adrenergic receptors stimulator and blockers and beta-blocker on the ovary and endocrinological activity in heifers during superovulation.	2006 Nov	17242481
Adrenergic stimulation and blocking of hormonal secretion activity of cultured cow granulosa cells.	2006 Nov	17242478
Atipamezole in the management of detomidine overdose in a pony.	2007 Jan	17238965
Reversible immobilization of asiatic black bear (Ursus thibetanus) with detomidine-tiletamine-zolazepam and atipamezole.	2008 Dec	19110696
Use of multichannel electrointestinography for noninvasive assessment of myoelectrical activity in the cecum and large colon of horses.	2008 Jun	18518649
Radiographic parameters for diagnosing sand colic in horses.	2008 Jun 13	18554381
Pharmacokinetics of detomidine and its metabolites following intravenous and intramuscular administration in horses.	2009 Apr	19562897
Comparison of azaperone-detomidine-butorphanol-ketamine and azaperone-tiletamine-zolazepam for anaesthesia in piglets.	2009 Mar	19239653
Accidental poisoning with detomidine and butorphanol.	2010 Sep	20573843

Patents

Sample Use Guides

In Vivo Use Guide

for horses: Oral (gel): 0.04 mg/kg; Intravenous or Intramuscular injection: 0.02-0.04 mg/kg

Route of Administration: Other

In Vitro Use Guide

The sedative alpha2-adrenoceptor agonists medetomidine and detomidine inhibited aldosterone release (range 10-1000 nM). The 4-substituted imidazoles atipamezole, detomidine, and medetomidine inhibited mitochondrial cytochrome P450(11beta/18) in vitro.

Name

Type

Language

DETOMIDINE HYDROCHLORIDE FOR VETERINARY USE

Preferred Name

English

DETOMIDINE HYDROCHLORIDE

Official Name

English

DETOMIDINE HYDROCHLORIDE [MI]

Common Name

English

DETOMIDINE HYDROCHLORIDE FOR VETERINARY USE [EP MONOGRAPH]

Common Name

English

DETOMIDINE HYDROCHLORIDE [GREEN BOOK]

Common Name

English

DETOMIDINE HYDROCHLORIDE [MART.]

Common Name

English

1H-IMIDAZOLE, 4-((2,3-DIMETHYLPHENYL)METHYL)-, MONOHYDROCHLORIDE

Common Name

English

MPV-253 AII

Code

English

DETOMIDINE HCL

Common Name

English

DETOMIDINE HYDROCHLORIDE [USAN]

Common Name

English

4-(2,3-Dimethylbenzyl)imidazole monohydrochloride

Systematic Name

English

Classification Tree Code System Code

CFR

21 CFR 522.536