Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H14N2.ClH |
| Molecular Weight | 222.714 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC1=CC=CC(CC2=CNC=N2)=C1C
InChI
InChIKey=OIWRDXKNDCJZSM-UHFFFAOYSA-N
InChI=1S/C12H14N2.ClH/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12;/h3-5,7-8H,6H2,1-2H3,(H,13,14);1H
Detomodine hydrochloride is a sedative with analgesic properties and α2-adrenergic agonist The dose-dependent sedative and analgesic effects reduce production of excitatory neurotransmitters, thereby calming the horse, relieving abdominal pain, and facilitating bronchoscopy and other procedures. Currently, detomidine is only licensed for use in horses.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Standing sedation in African elephants (Loxodonta africana) using detomidine-butorphanol combinations. | 2005 Jun |
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| Effect of defocused CO2 laser on equine tissue perfusion. | 2006 |
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| Dissociative anaesthesia during field and hospital conditions for castration of colts. | 2006 |
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| Gait pattern of the ataxic horse compared to sedated and nonsedated horses. | 2006 Aug |
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| Comparison of intraoperative pain responses following intratesticular or mesorchial injection of lidocaine in standing horses undergoing laparoscopic cryptorchidectomy. | 2006 Dec 1 |
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| Effect of head position on intraocular pressure in horses. | 2006 Jul |
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| Effects of xylazine, medetomidine, detomidine, and diazepam on sedation, heart and respiratory rates, and cloacal temperature in rock partridges (Alectoris graeca). | 2006 Jun |
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| The stress caused by laparoscopy in sheep and its alleviation. | 2006 Jun |
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| Antagonism of detomidine sedation in the horse using intravenous tolazoline or atipamezole. | 2006 May |
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| The effect of hyoscine on dobutamine requirement in spontaneously breathing horses anaesthetized with halothane. | 2006 May |
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| Clinical evaluation of intranasal benzodiazepines, alpha-agonists and their antagonists in canaries. | 2006 May |
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| The influence of alpha-adrenergic receptors stimulator and blockers and beta-blocker on the ovary and endocrinological activity in heifers during superovulation. | 2006 Nov |
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| Adrenergic stimulation and blocking of hormonal secretion activity of cultured cow granulosa cells. | 2006 Nov |
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| Serial chemical restraint for treatment of decubitus ulcers in two neonatal white rhinoceroses (Ceratotherium simum). | 2006 Sep |
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| Left- and right-sided laparoscopic-assisted nephrectomy in standing horses with unilateral renal disease. | 2007 Aug |
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| The use of alpha-2 agonists in the equine practice: comparison between three molecules. | 2007 Aug |
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| Atipamezole in the management of detomidine overdose in a pony. | 2007 Jan |
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| The effects of detomidine, romifidine or acepromazine on echocardiographic measurements and cardiac function in normal horses. | 2007 Jan |
|
| Detecting early kidney damage in horses with colic by measuring matrix metalloproteinase -9 and -2, other enzymes, urinary glucose and total proteins. | 2007 Jan 23 |
|
| Radiographic closure time of appendicular growth plates in the Icelandic horse. | 2007 Jul 17 |
|
| Caries in the infundibulum of the second upper premolar tooth in the horse. | 2007 Mar 28 |
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| Sedation with detomidine and acepromazine influences the endoscopic evaluation of laryngeal function in horses. | 2007 Nov |
|
| A point mutation in a herpesvirus polymerase determines neuropathogenicity. | 2007 Nov |
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| Metabolism before, during and after anaesthesia in colic and healthy horses. | 2007 Nov 15 |
|
| The cardiopulmonary effects of etorphine, azaperone, detomidine, and butorphanol in field-anesthetized white rhinoceroses (Ceratotherium simum). | 2007 Sep |
|
| Reversible immobilization of asiatic black bear (Ursus thibetanus) with detomidine-tiletamine-zolazepam and atipamezole. | 2008 Dec |
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| Use of multichannel electrointestinography for noninvasive assessment of myoelectrical activity in the cecum and large colon of horses. | 2008 Jun |
|
| Radiographic parameters for diagnosing sand colic in horses. | 2008 Jun 13 |
|
| Development of a composite orthopaedic pain scale in horses. | 2008 Oct |
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| Pharmacokinetics of detomidine and its metabolites following intravenous and intramuscular administration in horses. | 2009 Apr |
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| Effects of dobutamine on cardiac index and arterial blood pressure in isoflurane-anaesthetized horses under clinical conditions. | 2009 Aug |
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| A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopy. | 2009 Jan |
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| Vascular perfusion of reproductive organs in pony mares and heifers during sedation with detomidine or xylazine. | 2009 Jan |
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| Analgesic effect of butorphanol in ponies following castration. | 2009 Jul |
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| Comparison of the effects of the alpha-2 agonists detomidine, romifidine and xylazine on nociceptive withdrawal reflex and temporal summation in horses. | 2009 Jul |
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| Steroid hormone receptors ERalpha and PR characterised by immunohistochemistry in the mare adrenal gland. | 2009 Jul 22 |
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| Effect of detomidine on visceral and somatic nociception and duodenal motility in conscious adult horses. | 2009 Mar |
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| Comparison of azaperone-detomidine-butorphanol-ketamine and azaperone-tiletamine-zolazepam for anaesthesia in piglets. | 2009 Mar |
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| Metabolism during anaesthesia and recovery in colic and healthy horses: a microdialysis study. | 2009 Mar 10 |
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| Pharmacokinetics of detomidine administered to horses at rest and after maximal exercise. | 2009 May |
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| Effect of sedation with detomidine and butorphanol on pulmonary gas exchange in the horse. | 2009 May 7 |
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| Plasma concentrations, behavioural and physiological effects following intravenous and intramuscular detomidine in horses. | 2009 Nov |
|
| Histological and immunohistochemical evaluation of autologous cultured bone marrow mesenchymal stem cells and bone marrow mononucleated cells in collagenase-induced tendinitis of equine superficial digital flexor tendon. | 2010 |
|
| Comparison of intraoperative behavioral and hormonal responses to noxious stimuli between mares sedated with caudal epidural detomidine hydrochloride or a continuous intravenous infusion of detomidine hydrochloride for standing laparoscopic ovariectomy. | 2010 Aug |
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| Human exposures to immobilising agents: results of an online survey. | 2010 Aug 28 |
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| Tachypnea and antipyresis in febrile horses after sedation with alpha-agonists. | 2010 Jul-Aug |
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| Immobilization and intravenous anesthesia in a Sumatran rhinoceros (Dicerorhinus sumatrensis). | 2010 Mar |
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| Anesthetic management of a white rhinoceros (Ceratotherium simum) undergoing an emergency exploratory celiotomy for colic. | 2010 May |
|
| Total intravenous anesthesia with midazolam, ketamine, and xylazine or detomidine following induction with tiletamine, zolazepam, and xylazine in red deer (Cervus elaphus hippelaphus) undergoing surgery. | 2010 Oct |
|
| Accidental poisoning with detomidine and butorphanol. | 2010 Sep |
Patents
Sample Use Guides
for horses:
Oral (gel): 0.04 mg/kg;
Intravenous or Intramuscular injection: 0.02-0.04 mg/kg
Route of Administration:
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CFR |
21 CFR 522.536
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NCI_THESAURUS |
C29709
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48928
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SUB11892MIG
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95K4LKB6QE
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C041255
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CHEMBL2110829
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100000076086
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m4209
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95K4LKB6QE
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C75038
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ACTIVE MOIETY
SUBSTANCE RECORD
