U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H34O
Molecular Weight 242.4412
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CETYL ALCOHOL

SMILES

CCCCCCCCCCCCCCCCO

InChI

InChIKey=BXWNKGSJHAJOGX-UHFFFAOYSA-N
InChI=1S/C16H34O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h17H,2-16H2,1H3

HIDE SMILES / InChI

Description
Curator's Comment:: description was created based on several sources, including: https://www.drugs.com/dict/cetyl-alcohol.html http://www.wikidoc.org/index.php/Cetyl_alcohol http://wisderm.com/ingredients/Cetyl+Alcohol#ref-17

Cetyl alcohol is the 16-carbon alcohol corresponding to palmitic acid, so called because it is isolated from among the hydrolysis products of spermaceti. This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy). Most emollients can be used safely and effectively with no side effects. However, burning, stinging, redness, or irritation may occur. A very serious allergic reaction to this drug is rare.

Originator

Sources: DOI: 10.1111/j.1478-4408.1890.tb02251.x

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P51648
Gene ID: 224.0
Gene Symbol: ALDH3A2
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
EXOSURF NEONATAL

Approved Use

Colfosceril, cetyl alcohol, and tyloxapol combination is indicated for the prophylactic treatment of infants with birth weights of less than 1350 grams who are at risk of developing respiratory distress syndrome.

Launch Date

6.4946877E11
Palliative
ALL DAY SKIN RELIEF WITH COLLOIDAL OATS

Approved Use

Relieves dry, itchy skin and provides hydration.
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Biodegradation of long-chain n-paraffins from waste oil of car engine by Acinetobacter sp.
2001
Preparation and characterization of flurbiprofen beads by melt solidification technique.
2003 Dec 16
Evaluation of hydrophobic materials as matrices for controlled-release drug delivery.
2003 Jul
Concomitant allergic reaction to cetyl alcohol and crotamiton.
2003 Nov
Influence of modified natural and synthetic surfactant preparations on bacterial killing by polymorphonuclear leucocytes.
2004
A novel approach in the assessment of polymeric film formation and film adhesion on different pharmaceutical solid substrates.
2004 Apr 5
Covalent attachment of phospholipid analogous polymers to modify a polymeric membrane surface: a novel approach.
2004 Feb 17
Contact dermatitis due to lanoconazole, cetyl alcohol and diethyl sebacate in lanoconazole cream.
2004 Jan
Natural ligands of hamster aphrodisin.
2004 Jun
Analysis of the labial gland secretions of the male bumble bee Bombus perplexus Cresson (Hymenoptera: Apidae) from North America.
2004 Mar-Apr
Theoretical scales of hydrogen bond acidity and basicity for application in QSAR/QSPR studies and drug design. Partitioning of aliphatic compounds.
2004 May-Jun
Melt solidification technique: incorporation of higher wax content in ibuprofen beads.
2004 Oct 8
A simple treatment for head lice: dry-on, suffocation-based pediculicide.
2004 Sep
Paclitaxel nanoparticles for the potential treatment of brain tumors.
2004 Sep 30
[Production of surfactants by Rhodococcus erythropolis strain EK-1, grown on hydrophilic and hydrophobic substrates].
2004 Sep-Oct
Analysis of the labial gland secretions of the male bumblebee Bombus griseocollis (Hymenoptera: Apidae).
2004 Sep-Oct
Cetaphil cleanser (Nuvo lotion) cures head lice.
2005 Dec
Hydrophobization of glass surface by adsorption of poly(dimethylsiloxane).
2005 Dec 6
Width of the hexadecane-water interface: a discrepancy resolved.
2005 Dec 6
Modifying calf lung surfactant by hexadecanol.
2005 Feb 1
Nuvo lotion and the future of head-lice treatment.
2005 May
Blood compatibility of cetyl alcohol/polysorbate-based nanoparticles.
2005 Nov
A concentration-dependent multi-term linear free energy relationship for sorption of organic compounds to soils based on the hexadecane dilute-solution reference state.
2005 Nov 15
Aggregation behavior of heteroleptic tris(phthalocyaninato) dysprosium complexes with different alkoxy chains in monolayer or multilayer solid films.
2005 Nov 22
Photoallergic and allergic reaction to 2-hydroxy-4-methoxybenzophenone (sunscreen) and allergy to cetyl alcohol in cosmetic cream.
2005 Sep
Displacement of sterols from sterol/sphingomyelin domains in fluid bilayer membranes by competing molecules.
2005 Sep 15
Detection of NAD+-dependent alcohol dehydrogenase activities in YR-1 strain of Mucor circinelloides, a potential bioremediator of petroleum contaminated soils.
2005 Spring
Silicon nanoparticles: applications in cell biology and medicine.
2006
The effect of Cetaphil Gentle Skin Cleanser on the skin barrier of patients with rosacea.
2006 Apr
Evaluation of otoscope cone cleaning and disinfection procedures commonly used in veterinary medical practices: a pilot study.
2006 Apr
Dialkyl 3,3'-thiodipropionate and dialkyl 2,2'-thiodiacetate antioxidants by lipase-catalyzed esterification and transesterification.
2006 Apr 19
Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia.
2006 Aug
Interfacial rheology and structure of straight-chain and branched fatty alcohol mixtures.
2006 Jun 6
Effects of dioctadecyl dimethyl ammonium chloride on the rheological behavior of behenyl trimethyl ammonium chloride/1-hexadecanol/water ternary system.
2006 Oct 1
The metabolism of fatty alcohols in lipid nanoparticles by alcohol dehydrogenase.
2006 Sep
Final report on the amended safety assessment of Propyl Gallate.
2007
Comedogenicity in rabbit: some cosmetic ingredients/vehicles.
2007
Beneficial use of Cetaphil moisturizing cream as part of a daily skin care regimen for individuals with rosacea.
2007
Zeolite-catalyzed Helferich-type glycosylation of long-chain alcohols. Synthesis of acetylated alkyl 1,2-trans glycopyranosides and alkyl 1,2-cis C2-hydroxy-glycopyranosides.
2007 Apr 9
1H NMR investigations of inclusion complexes between beta-cyclodextrin and 1-hexadecanol.
2007 Dec
Putative chemical signals about sex, individuality, and genetic background in the preputial gland and urine of the house mouse (Mus musculus).
2007 Mar
Formulation of sustained-release verapamil HCl and diltiazem HCl semisolid matrix capsules.
2008
Mechanical properties of hexadecane-water interfaces with adsorbed hydrophobic bacteria.
2008 Apr 1
Adsorption and hysteresis of bisphenol A and 17alpha-ethinyl estradiol on carbon nanomaterials.
2008 Aug 1
A sugar cane native dextran as an innovative functional excipient for the development of pharmaceutical tablets.
2008 Feb
Potential of hexadecane-utilizing soil-microorganisms for growth on hexadecanol, hexadecanal and hexadecanoic acid as sole sources of carbon and energy.
2008 Jan
Preparation and characterization of herbal creams for improvement of skin viscoelastic properties.
2008 Jun
Novel molecular precursor of lanthanide complexes with long chain mono cis-butene dicarboxylate to the controlled synthesis of Y2O3:Eu3+ phosphors.
2008 Mar
Precursor system of liquid crystalline phase containing propolis microparticles for the treatment of periodontal disease: development and characterization.
2008 Mar
Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat.
2008 Sep
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment:: Suspension: 13.5 mg of colfosceril palmitate, 1.5 mg of cetyl alcohol, and 1 mg of tyloxapol per mL, when reconstituted with 8 mL of Sterile Water for Injection supplied by manufacturer
5 mL of reconstituted suspension per kg of body weight administered (in two half-doses) as soon as possible after diagnosis of respiratory distress syndrome (RDS) is confirmed; a second dose (given in two half-doses) should be administered approximately twelve hours after the first dose, provided that the infant remains on mechanical ventilation.
Route of Administration: Intratracheal
In Vitro Use Guide
Unknown
Name Type Language
CETYL ALCOHOL
EP   HSDB   II   INCI   MART.   MI   USP-RS   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
CETYL ALCOHOL [MART.]
Common Name English
FEMA NO. 2554
Code English
CETYL ALCOHOL [USP-RS]
Common Name English
CETYL ALCOHOL [MI]
Common Name English
N-1-HEXADECANOL
Common Name English
HEXADECANOL
Systematic Name English
CETYL ALCHOL
Common Name English
CETYL ALCOHOL [EP MONOGRAPH]
Common Name English
PALMITIC ALCOHOL
Common Name English
CETYL ALCOHOL [VANDF]
Common Name English
NSC-4194
Code English
HEXADECYL ALCOHOL
Systematic Name English
ALCOHOL CETYLICUS [WHO-IP LATIN]
Common Name English
CETYL ALCOHOL [WHO-IP]
Common Name English
PALMITYL ALCOHOL
Systematic Name English
CETANOL
JAN  
Systematic Name English
CETYL ALCOHOL [INCI]
Common Name English
1-HEXADECANOL [FHFI]
Common Name English
CETYL ALCOHOL [II]
Common Name English
CETYL ALCOHOL [WHO-DD]
Common Name English
N-HEXADECANOL
Common Name English
CETYL ALCOHOL [HSDB]
Common Name English
CETANOL [JAN]
Common Name English
1-HEXADECANOL
FHFI  
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C218
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
FDA ORPHAN DRUG 68492
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
FDA ORPHAN DRUG 14886
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
JECFA EVALUATION 1-HEXADECANOL
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
CFR 21 CFR 172.515
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
EPA PESTICIDE CODE 1508
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
Code System Code Type Description
DRUG BANK
DB09494
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY
NCI_THESAURUS
C47442
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY
EVMPD
SUB12479MIG
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY
CAS
124-29-8
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
ALTERNATIVE
MESH
C005031
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY
PUBCHEM
2682
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY
ECHA (EC/EINECS)
253-149-0
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY
HSDB
2643
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY
RXCUI
20615
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY RxNorm
MERCK INDEX
M3297
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY Merck Index
EPA CompTox
36653-82-4
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY
WIKIPEDIA
CETYL ALCOHOL
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY
FDA UNII
936JST6JCN
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY
ChEMBL
CHEMBL706
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY
DRUG CENTRAL
4750
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
CETYL ALCOHOL
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY Description: Unctuous, colourless flakes or a white, crystalline mass; odour, faint and characteristic. Solubility: Practically insoluble in water; soluble in ethanol (~750 g/l) TS and ether R. Category: Emulsifying agent; viscosity-increasing agent. Storage: Cetyl alcohol should be kept in a well-closed container. Definition: Cetyl alcohol is a mixture of solid alcohols consisting mainly of 1-hexadecanol (C16H34O).
USP_CATALOG
1103003
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY USP-RS
CAS
36653-82-4
Created by admin on Fri Jun 25 21:17:10 UTC 2021 , Edited by admin on Fri Jun 25 21:17:10 UTC 2021
PRIMARY