U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H34O
Molecular Weight 242.4406
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CETYL ALCOHOL

SMILES

CCCCCCCCCCCCCCCCO

InChI

InChIKey=BXWNKGSJHAJOGX-UHFFFAOYSA-N
InChI=1S/C16H34O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h17H,2-16H2,1H3

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including: https://www.drugs.com/dict/cetyl-alcohol.html http://www.wikidoc.org/index.php/Cetyl_alcohol http://wisderm.com/ingredients/Cetyl+Alcohol#ref-17

Cetyl alcohol is the 16-carbon alcohol corresponding to palmitic acid, so called because it is isolated from among the hydrolysis products of spermaceti. This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy). Most emollients can be used safely and effectively with no side effects. However, burning, stinging, redness, or irritation may occur. A very serious allergic reaction to this drug is rare.

Originator

Sources: DOI: 10.1111/j.1478-4408.1890.tb02251.x

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P51648
Gene ID: 224.0
Gene Symbol: ALDH3A2
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
EXOSURF NEONATAL

Approved Use

Colfosceril, cetyl alcohol, and tyloxapol combination is indicated for the prophylactic treatment of infants with birth weights of less than 1350 grams who are at risk of developing respiratory distress syndrome.

Launch Date

1990
Palliative
ALL DAY SKIN RELIEF WITH COLLOIDAL OATS

Approved Use

Relieves dry, itchy skin and provides hydration.
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Biodegradation of long-chain n-paraffins from waste oil of car engine by Acinetobacter sp.
2001
Preparation and characterization of flurbiprofen beads by melt solidification technique.
2003 Dec 16
Evaluation of hydrophobic materials as matrices for controlled-release drug delivery.
2003 Jul
Influence of modified natural and synthetic surfactant preparations on bacterial killing by polymorphonuclear leucocytes.
2004
Structure and rheology of semisolid o/w creams containing cetyl alcohol/non-ionic surfactant mixed emulsifier and different polymers.
2004 Apr
A novel approach in the assessment of polymeric film formation and film adhesion on different pharmaceutical solid substrates.
2004 Apr 5
Covalent attachment of phospholipid analogous polymers to modify a polymeric membrane surface: a novel approach.
2004 Feb 17
Natural ligands of hamster aphrodisin.
2004 Jun
Analysis of the labial gland secretions of the male bumble bee Bombus perplexus Cresson (Hymenoptera: Apidae) from North America.
2004 Mar-Apr
Melt solidification technique: incorporation of higher wax content in ibuprofen beads.
2004 Oct 8
A simple treatment for head lice: dry-on, suffocation-based pediculicide.
2004 Sep
Paclitaxel nanoparticles for the potential treatment of brain tumors.
2004 Sep 30
[Production of surfactants by Rhodococcus erythropolis strain EK-1, grown on hydrophilic and hydrophobic substrates].
2004 Sep-Oct
Analysis of the labial gland secretions of the male bumblebee Bombus griseocollis (Hymenoptera: Apidae).
2004 Sep-Oct
Hydrophobization of glass surface by adsorption of poly(dimethylsiloxane).
2005 Dec 6
Modifying calf lung surfactant by hexadecanol.
2005 Feb 1
Nuvo lotion and the future of head-lice treatment.
2005 May
Blood compatibility of cetyl alcohol/polysorbate-based nanoparticles.
2005 Nov
Aggregation behavior of heteroleptic tris(phthalocyaninato) dysprosium complexes with different alkoxy chains in monolayer or multilayer solid films.
2005 Nov 22
Photoallergic and allergic reaction to 2-hydroxy-4-methoxybenzophenone (sunscreen) and allergy to cetyl alcohol in cosmetic cream.
2005 Sep
Displacement of sterols from sterol/sphingomyelin domains in fluid bilayer membranes by competing molecules.
2005 Sep 15
Detection of NAD+-dependent alcohol dehydrogenase activities in YR-1 strain of Mucor circinelloides, a potential bioremediator of petroleum contaminated soils.
2005 Spring
Evaluation of otoscope cone cleaning and disinfection procedures commonly used in veterinary medical practices: a pilot study.
2006 Apr
Selection of surfactants for stable paraffin-in-water dispersions, undergoing solid-liquid transition of the dispersed particles.
2006 Apr 11
Dialkyl 3,3'-thiodipropionate and dialkyl 2,2'-thiodiacetate antioxidants by lipase-catalyzed esterification and transesterification.
2006 Apr 19
Cytosolic triacylglycerol biosynthetic pathway in oilseeds. Molecular cloning and expression of peanut cytosolic diacylglycerol acyltransferase.
2006 Aug
"Special" formula for head lice treatment--not so special, after all.
2006 Feb
Computer studies on the effects of long chain alcohols on sodium dodecyl sulfate (SDS) molecules in SDS/dodecanol and SDS/hexadecanol monolayers at the air/water interface.
2006 Jul 6
Effects of pressure sensitive adhesives and chemical permeation enhancers on the permeability of fentanyl through excised rat skin.
2006 Jun
Development of a respirable, sustained release microcarrier for 5-fluorouracil II: In vitro and in vivo optimization of lipid coated nanoparticles.
2006 May
Effects of dioctadecyl dimethyl ammonium chloride on the rheological behavior of behenyl trimethyl ammonium chloride/1-hexadecanol/water ternary system.
2006 Oct 1
The metabolism of fatty alcohols in lipid nanoparticles by alcohol dehydrogenase.
2006 Sep
Final report on the amended safety assessment of Propyl Gallate.
2007
Comedogenicity in rabbit: some cosmetic ingredients/vehicles.
2007
Zeolite-catalyzed Helferich-type glycosylation of long-chain alcohols. Synthesis of acetylated alkyl 1,2-trans glycopyranosides and alkyl 1,2-cis C2-hydroxy-glycopyranosides.
2007 Apr 9
1H NMR investigations of inclusion complexes between beta-cyclodextrin and 1-hexadecanol.
2007 Dec
Modifying dipalmitoylphosphatidylcholine monolayers by n-hexadecanol and dipalmitoylglycerol.
2007 Feb
Cholesterol displacement from membrane phospholipids by hexadecanol.
2007 Sep 15
Formulation of sustained-release verapamil HCl and diltiazem HCl semisolid matrix capsules.
2008
Mechanical properties of hexadecane-water interfaces with adsorbed hydrophobic bacteria.
2008 Apr 1
Adsorption and hysteresis of bisphenol A and 17alpha-ethinyl estradiol on carbon nanomaterials.
2008 Aug 1
A sugar cane native dextran as an innovative functional excipient for the development of pharmaceutical tablets.
2008 Feb
Substrate specificity of a long-chain alkylamine-degrading Pseudomonas sp isolated from activated sludge.
2008 Feb
Enhanced sorption of polycyclic aromatic hydrocarbons to tetra-alkyl ammonium modified smectites via cation-pi interactions.
2008 Feb 15
The male sex pheromone of the butterfly Bicyclus anynana: towards an evolutionary analysis.
2008 Jul 23
Molecular modeling of surfactant covered oil-water interfaces: Dynamics, microstructure, and barrier for mass transport.
2008 Jun 21
Novel molecular precursor of lanthanide complexes with long chain mono cis-butene dicarboxylate to the controlled synthesis of Y2O3:Eu3+ phosphors.
2008 Mar
Hydrophobic bacteria at the hexadecane-water interface: examination of micrometre-scale interfacial properties.
2008 Nov 15
Chemistry of the cephalic labial gland secretions of male Bombus morrisoni and B. rufocinctus, two North American bumblebee males with perching behavior.
2008 Oct
Dual role of preputial gland secretion and its major components in sex recognition of mice.
2008 Oct 20
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Suspension: 13.5 mg of colfosceril palmitate, 1.5 mg of cetyl alcohol, and 1 mg of tyloxapol per mL, when reconstituted with 8 mL of Sterile Water for Injection supplied by manufacturer
5 mL of reconstituted suspension per kg of body weight administered (in two half-doses) as soon as possible after diagnosis of respiratory distress syndrome (RDS) is confirmed; a second dose (given in two half-doses) should be administered approximately twelve hours after the first dose, provided that the infant remains on mechanical ventilation.
Route of Administration: Intratracheal
In Vitro Use Guide
Unknown
Name Type Language
CETYL ALCOHOL
EP   HSDB   II   INCI   MART.   MI   USP-RS   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
CETYL ALCOHOL [MART.]
Common Name English
FEMA NO. 2554
Code English
CETYL ALCOHOL [USP-RS]
Common Name English
CETYL ALCOHOL [MI]
Common Name English
N-1-HEXADECANOL
Common Name English
HEXADECANOL
Systematic Name English
CETYL ALCHOL
Common Name English
CETYL ALCOHOL [EP MONOGRAPH]
Common Name English
PALMITIC ALCOHOL
Common Name English
CETYL ALCOHOL [VANDF]
Common Name English
NSC-4194
Code English
HEXADECYL ALCOHOL
Systematic Name English
ALCOHOL CETYLICUS [WHO-IP LATIN]
Common Name English
CETYL ALCOHOL [WHO-IP]
Common Name English
Cetyl alcohol [WHO-DD]
Common Name English
PALMITYL ALCOHOL
Systematic Name English
CETANOL
JAN  
Systematic Name English
CETYL ALCOHOL [INCI]
Common Name English
1-HEXADECANOL [FHFI]
Common Name English
CETYL ALCOHOL [II]
Common Name English
N-HEXADECANOL
Common Name English
CETYL ALCOHOL [HSDB]
Common Name English
CETANOL [JAN]
Common Name English
1-Hexadecanol
FHFI  
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C218
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FDA ORPHAN DRUG 68492
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FDA ORPHAN DRUG 14886
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JECFA EVALUATION 1-HEXADECANOL
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CFR 21 CFR 172.515
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EPA PESTICIDE CODE 1508
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Code System Code Type Description
CHEBI
16125
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PRIMARY
DRUG BANK
DB09494
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PRIMARY
SMS_ID
100000078547
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PRIMARY
NCI_THESAURUS
C47442
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PRIMARY
RS_ITEM_NUM
1103003
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PRIMARY
EVMPD
SUB12479MIG
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PRIMARY
CAS
124-29-8
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ALTERNATIVE
JECFA MONOGRAPH
255
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PRIMARY
MESH
C005031
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PRIMARY
NSC
4194
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PRIMARY
PUBCHEM
2682
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PRIMARY
ECHA (EC/EINECS)
253-149-0
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PRIMARY
HSDB
2643
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PRIMARY
RXCUI
20615
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PRIMARY RxNorm
MERCK INDEX
m3297
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PRIMARY Merck Index
EPA CompTox
DTXSID4027991
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PRIMARY
WIKIPEDIA
CETYL ALCOHOL
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PRIMARY
FDA UNII
936JST6JCN
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PRIMARY
ChEMBL
CHEMBL706
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PRIMARY
DRUG CENTRAL
4750
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PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
CETYL ALCOHOL
Created by admin on Fri Dec 15 15:04:52 GMT 2023 , Edited by admin on Fri Dec 15 15:04:52 GMT 2023
PRIMARY Description: Unctuous, colourless flakes or a white, crystalline mass; odour, faint and characteristic. Solubility: Practically insoluble in water; soluble in ethanol (~750 g/l) TS and ether R. Category: Emulsifying agent; viscosity-increasing agent. Storage: Cetyl alcohol should be kept in a well-closed container. Definition: Cetyl alcohol is a mixture of solid alcohols consisting mainly of 1-hexadecanol (C16H34O).
CAS
36653-82-4
Created by admin on Fri Dec 15 15:04:52 GMT 2023 , Edited by admin on Fri Dec 15 15:04:52 GMT 2023
PRIMARY
DAILYMED
936JST6JCN
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PRIMARY