Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H34O |
| Molecular Weight | 242.4412 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCCCCCCCCO
InChI
InChIKey=BXWNKGSJHAJOGX-UHFFFAOYSA-N
InChI=1S/C16H34O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h17H,2-16H2,1H3
DescriptionCurator's Comment:: description was created based on several sources, including:
https://www.drugs.com/dict/cetyl-alcohol.html
http://www.wikidoc.org/index.php/Cetyl_alcohol
http://wisderm.com/ingredients/Cetyl+Alcohol#ref-17
Curator's Comment:: description was created based on several sources, including:
https://www.drugs.com/dict/cetyl-alcohol.html
http://www.wikidoc.org/index.php/Cetyl_alcohol
http://wisderm.com/ingredients/Cetyl+Alcohol#ref-17
Cetyl alcohol is the 16-carbon alcohol corresponding to palmitic acid, so called because it is isolated from among the hydrolysis products of spermaceti. This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy). Most emollients can be used safely and effectively with no side effects. However, burning, stinging, redness, or irritation may occur. A very serious allergic reaction to this drug is rare.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P51648 Gene ID: 224.0 Gene Symbol: ALDH3A2 Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | EXOSURF NEONATAL Approved UseColfosceril, cetyl alcohol, and tyloxapol combination is indicated for the prophylactic treatment of infants with birth weights of less than 1350 grams who are at risk of developing respiratory distress syndrome. Launch Date6.4946877E11 |
|||
| Palliative | ALL DAY SKIN RELIEF WITH COLLOIDAL OATS Approved UseRelieves dry, itchy skin and provides hydration. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Biodegradation of long-chain n-paraffins from waste oil of car engine by Acinetobacter sp. | 2001 |
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| Preparation and characterization of flurbiprofen beads by melt solidification technique. | 2003 Dec 16 |
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| Evaluation of hydrophobic materials as matrices for controlled-release drug delivery. | 2003 Jul |
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| Concomitant allergic reaction to cetyl alcohol and crotamiton. | 2003 Nov |
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| Influence of modified natural and synthetic surfactant preparations on bacterial killing by polymorphonuclear leucocytes. | 2004 |
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| A novel approach in the assessment of polymeric film formation and film adhesion on different pharmaceutical solid substrates. | 2004 Apr 5 |
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| Covalent attachment of phospholipid analogous polymers to modify a polymeric membrane surface: a novel approach. | 2004 Feb 17 |
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| Contact dermatitis due to lanoconazole, cetyl alcohol and diethyl sebacate in lanoconazole cream. | 2004 Jan |
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| Natural ligands of hamster aphrodisin. | 2004 Jun |
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| Analysis of the labial gland secretions of the male bumble bee Bombus perplexus Cresson (Hymenoptera: Apidae) from North America. | 2004 Mar-Apr |
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| Theoretical scales of hydrogen bond acidity and basicity for application in QSAR/QSPR studies and drug design. Partitioning of aliphatic compounds. | 2004 May-Jun |
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| Melt solidification technique: incorporation of higher wax content in ibuprofen beads. | 2004 Oct 8 |
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| A simple treatment for head lice: dry-on, suffocation-based pediculicide. | 2004 Sep |
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| Paclitaxel nanoparticles for the potential treatment of brain tumors. | 2004 Sep 30 |
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| [Production of surfactants by Rhodococcus erythropolis strain EK-1, grown on hydrophilic and hydrophobic substrates]. | 2004 Sep-Oct |
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| Analysis of the labial gland secretions of the male bumblebee Bombus griseocollis (Hymenoptera: Apidae). | 2004 Sep-Oct |
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| Cetaphil cleanser (Nuvo lotion) cures head lice. | 2005 Dec |
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| Hydrophobization of glass surface by adsorption of poly(dimethylsiloxane). | 2005 Dec 6 |
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| Width of the hexadecane-water interface: a discrepancy resolved. | 2005 Dec 6 |
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| Modifying calf lung surfactant by hexadecanol. | 2005 Feb 1 |
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| Nuvo lotion and the future of head-lice treatment. | 2005 May |
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| Blood compatibility of cetyl alcohol/polysorbate-based nanoparticles. | 2005 Nov |
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| A concentration-dependent multi-term linear free energy relationship for sorption of organic compounds to soils based on the hexadecane dilute-solution reference state. | 2005 Nov 15 |
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| Aggregation behavior of heteroleptic tris(phthalocyaninato) dysprosium complexes with different alkoxy chains in monolayer or multilayer solid films. | 2005 Nov 22 |
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| Photoallergic and allergic reaction to 2-hydroxy-4-methoxybenzophenone (sunscreen) and allergy to cetyl alcohol in cosmetic cream. | 2005 Sep |
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| Displacement of sterols from sterol/sphingomyelin domains in fluid bilayer membranes by competing molecules. | 2005 Sep 15 |
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| Detection of NAD+-dependent alcohol dehydrogenase activities in YR-1 strain of Mucor circinelloides, a potential bioremediator of petroleum contaminated soils. | 2005 Spring |
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| Silicon nanoparticles: applications in cell biology and medicine. | 2006 |
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| The effect of Cetaphil Gentle Skin Cleanser on the skin barrier of patients with rosacea. | 2006 Apr |
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| Evaluation of otoscope cone cleaning and disinfection procedures commonly used in veterinary medical practices: a pilot study. | 2006 Apr |
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| Dialkyl 3,3'-thiodipropionate and dialkyl 2,2'-thiodiacetate antioxidants by lipase-catalyzed esterification and transesterification. | 2006 Apr 19 |
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| Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia. | 2006 Aug |
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| Interfacial rheology and structure of straight-chain and branched fatty alcohol mixtures. | 2006 Jun 6 |
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| Effects of dioctadecyl dimethyl ammonium chloride on the rheological behavior of behenyl trimethyl ammonium chloride/1-hexadecanol/water ternary system. | 2006 Oct 1 |
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| The metabolism of fatty alcohols in lipid nanoparticles by alcohol dehydrogenase. | 2006 Sep |
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| Final report on the amended safety assessment of Propyl Gallate. | 2007 |
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| Comedogenicity in rabbit: some cosmetic ingredients/vehicles. | 2007 |
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| Beneficial use of Cetaphil moisturizing cream as part of a daily skin care regimen for individuals with rosacea. | 2007 |
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| Zeolite-catalyzed Helferich-type glycosylation of long-chain alcohols. Synthesis of acetylated alkyl 1,2-trans glycopyranosides and alkyl 1,2-cis C2-hydroxy-glycopyranosides. | 2007 Apr 9 |
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| 1H NMR investigations of inclusion complexes between beta-cyclodextrin and 1-hexadecanol. | 2007 Dec |
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| Putative chemical signals about sex, individuality, and genetic background in the preputial gland and urine of the house mouse (Mus musculus). | 2007 Mar |
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| Formulation of sustained-release verapamil HCl and diltiazem HCl semisolid matrix capsules. | 2008 |
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| Mechanical properties of hexadecane-water interfaces with adsorbed hydrophobic bacteria. | 2008 Apr 1 |
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| Adsorption and hysteresis of bisphenol A and 17alpha-ethinyl estradiol on carbon nanomaterials. | 2008 Aug 1 |
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| A sugar cane native dextran as an innovative functional excipient for the development of pharmaceutical tablets. | 2008 Feb |
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| Potential of hexadecane-utilizing soil-microorganisms for growth on hexadecanol, hexadecanal and hexadecanoic acid as sole sources of carbon and energy. | 2008 Jan |
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| Preparation and characterization of herbal creams for improvement of skin viscoelastic properties. | 2008 Jun |
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| Novel molecular precursor of lanthanide complexes with long chain mono cis-butene dicarboxylate to the controlled synthesis of Y2O3:Eu3+ phosphors. | 2008 Mar |
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| Precursor system of liquid crystalline phase containing propolis microparticles for the treatment of periodontal disease: development and characterization. | 2008 Mar |
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| Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat. | 2008 Sep |
Patents
Sample Use Guides
In Vivo Use Guide
Curator's Comment:: Suspension: 13.5 mg of colfosceril palmitate, 1.5 mg of cetyl alcohol, and 1 mg of tyloxapol per mL, when reconstituted with 8 mL of Sterile Water for Injection supplied by manufacturer
5 mL of reconstituted suspension per kg of body weight administered (in two half-doses) as soon as possible after diagnosis of respiratory distress syndrome (RDS) is confirmed; a second dose (given in two half-doses) should be administered approximately twelve hours after the first dose, provided that the infant remains on mechanical ventilation.
Route of Administration:
Intratracheal
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C218
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FDA ORPHAN DRUG |
68492
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FDA ORPHAN DRUG |
14886
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JECFA EVALUATION |
1-HEXADECANOL
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CFR |
21 CFR 172.515
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EPA PESTICIDE CODE |
1508
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DB09494
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C47442
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SUB12479MIG
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124-29-8
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C005031
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2682
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253-149-0
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2643
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20615
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M3297
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PRIMARY | Merck Index | ||
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36653-82-4
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CETYL ALCOHOL
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936JST6JCN
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CHEMBL706
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4750
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CETYL ALCOHOL
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PRIMARY | Description: Unctuous, colourless flakes or a white, crystalline mass; odour, faint and characteristic. Solubility: Practically insoluble in water; soluble in ethanol (~750 g/l) TS and ether R. Category: Emulsifying agent; viscosity-increasing agent. Storage: Cetyl alcohol should be kept in a well-closed container. Definition: Cetyl alcohol is a mixture of solid alcohols consisting mainly of 1-hexadecanol (C16H34O). | ||
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1103003
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PRIMARY | USP-RS | ||
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36653-82-4
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PRIMARY |
ACTIVE MOIETY
