Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H34O |
| Molecular Weight | 242.4406 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCCCCCCCCO
InChI
InChIKey=BXWNKGSJHAJOGX-UHFFFAOYSA-N
InChI=1S/C16H34O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h17H,2-16H2,1H3
DescriptionCurator's Comment: description was created based on several sources, including:
https://www.drugs.com/dict/cetyl-alcohol.html
http://www.wikidoc.org/index.php/Cetyl_alcohol
http://wisderm.com/ingredients/Cetyl+Alcohol#ref-17
Curator's Comment: description was created based on several sources, including:
https://www.drugs.com/dict/cetyl-alcohol.html
http://www.wikidoc.org/index.php/Cetyl_alcohol
http://wisderm.com/ingredients/Cetyl+Alcohol#ref-17
Cetyl alcohol is the 16-carbon alcohol corresponding to palmitic acid, so called because it is isolated from among the hydrolysis products of spermaceti. This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy). Most emollients can be used safely and effectively with no side effects. However, burning, stinging, redness, or irritation may occur. A very serious allergic reaction to this drug is rare.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P51648 Gene ID: 224.0 Gene Symbol: ALDH3A2 Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | EXOSURF NEONATAL Approved UseColfosceril, cetyl alcohol, and tyloxapol combination is indicated for the prophylactic treatment of infants with birth weights of less than 1350 grams who are at risk of developing respiratory distress syndrome. Launch Date6.4946877E11 |
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| Palliative | ALL DAY SKIN RELIEF WITH COLLOIDAL OATS Approved UseRelieves dry, itchy skin and provides hydration. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Sjögren-Larsson syndrome: accumulation of free fatty alcohols in cultured fibroblasts and plasma. | 2000 Jul |
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| Solvent effect on ion-pair extraction of 2-(2-pyridylazo)-1-naphthol-4-sulfonate anion with solvated hydroxonium ion using alcohols and 1-octanol/octane mixed solvents. | 2001 Feb |
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| Rapid synthesis and turnover of brain microsomal ether phospholipids in the adult rat. | 2002 Jan |
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| Efficient synthesis of phospholipids from glycidyl phosphates. | 2002 Jan 11 |
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| Uniform titanium dioxide (TiO(2)) microcapsules prepared by glass membrane emulsification with subsequent solvent evaporation. | 2002 Jul-Aug |
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| Skin cleansing in neonates and infants--basics of cleansers. | 2002 Sep |
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| Relationship between internal phase volume and emulsion stability: the cetyl alcohol/stearyl alcohol system. | 2003 Aug |
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| Preparation and characterization of ibuprofen-cetyl alcohol beads by melt solidification technique: effect of variables. | 2003 Aug 11 |
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| Interactions among contaminants and nutritional lipids during mobilization by digestive fluids of marine invertebrates. | 2003 Jul 15 |
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| Natural ligands of hamster aphrodisin. | 2004 Jun |
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| Analysis of the labial gland secretions of the male bumble bee Bombus perplexus Cresson (Hymenoptera: Apidae) from North America. | 2004 Mar-Apr |
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| A simple treatment for head lice: dry-on, suffocation-based pediculicide. | 2004 Sep |
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| Paclitaxel nanoparticles for the potential treatment of brain tumors. | 2004 Sep 30 |
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| The effect of Cetaphil Gentle Skin Cleanser on the skin barrier of patients with rosacea. | 2006 Apr |
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| Evaluation of otoscope cone cleaning and disinfection procedures commonly used in veterinary medical practices: a pilot study. | 2006 Apr |
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| Development and optimization of a novel sustained-release dextran tablet formulation for propranolol hydrochloride. | 2006 Jul 6 |
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| Interfacial rheology and structure of straight-chain and branched fatty alcohol mixtures. | 2006 Jun 6 |
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| The metabolism of fatty alcohols in lipid nanoparticles by alcohol dehydrogenase. | 2006 Sep |
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| Final report on the amended safety assessment of Propyl Gallate. | 2007 |
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| Comedogenicity in rabbit: some cosmetic ingredients/vehicles. | 2007 |
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| Zeolite-catalyzed Helferich-type glycosylation of long-chain alcohols. Synthesis of acetylated alkyl 1,2-trans glycopyranosides and alkyl 1,2-cis C2-hydroxy-glycopyranosides. | 2007 Apr 9 |
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| 1H NMR investigations of inclusion complexes between beta-cyclodextrin and 1-hexadecanol. | 2007 Dec |
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| Modifying dipalmitoylphosphatidylcholine monolayers by n-hexadecanol and dipalmitoylglycerol. | 2007 Feb |
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| Putative chemical signals about sex, individuality, and genetic background in the preputial gland and urine of the house mouse (Mus musculus). | 2007 Mar |
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| Bovine serum albumin-sugar conjugates through the maillard reaction: effects on interfacial behavior and emulsifying ability. | 2008 |
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| Mechanical properties of hexadecane-water interfaces with adsorbed hydrophobic bacteria. | 2008 Apr 1 |
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| Substrate specificity of a long-chain alkylamine-degrading Pseudomonas sp isolated from activated sludge. | 2008 Feb |
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| Novel molecular precursor of lanthanide complexes with long chain mono cis-butene dicarboxylate to the controlled synthesis of Y2O3:Eu3+ phosphors. | 2008 Mar |
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| Hydrophobic bacteria at the hexadecane-water interface: examination of micrometre-scale interfacial properties. | 2008 Nov 15 |
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| Chemistry of the cephalic labial gland secretions of male Bombus morrisoni and B. rufocinctus, two North American bumblebee males with perching behavior. | 2008 Oct |
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| Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat. | 2008 Sep |
Patents
Sample Use Guides
In Vivo Use Guide
Curator's Comment: Suspension: 13.5 mg of colfosceril palmitate, 1.5 mg of cetyl alcohol, and 1 mg of tyloxapol per mL, when reconstituted with 8 mL of Sterile Water for Injection supplied by manufacturer
5 mL of reconstituted suspension per kg of body weight administered (in two half-doses) as soon as possible after diagnosis of respiratory distress syndrome (RDS) is confirmed; a second dose (given in two half-doses) should be administered approximately twelve hours after the first dose, provided that the infant remains on mechanical ventilation.
Route of Administration:
Intratracheal
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C218
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FDA ORPHAN DRUG |
68492
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FDA ORPHAN DRUG |
14886
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JECFA EVALUATION |
1-HEXADECANOL
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CFR |
21 CFR 172.515
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EPA PESTICIDE CODE |
1508
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DB09494
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100000078547
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C47442
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1103003
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C005031
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4194
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M3297
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DTXSID4027991
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CETYL ALCOHOL
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936JST6JCN
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CHEMBL706
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4750
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CETYL ALCOHOL
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PRIMARY | Description: Unctuous, colourless flakes or a white, crystalline mass; odour, faint and characteristic. Solubility: Practically insoluble in water; soluble in ethanol (~750 g/l) TS and ether R. Category: Emulsifying agent; viscosity-increasing agent. Storage: Cetyl alcohol should be kept in a well-closed container. Definition: Cetyl alcohol is a mixture of solid alcohols consisting mainly of 1-hexadecanol (C16H34O). | ||
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36653-82-4
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936JST6JCN
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ACTIVE MOIETY
