U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H34O
Molecular Weight 242.4406
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CETYL ALCOHOL

SMILES

CCCCCCCCCCCCCCCCO

InChI

InChIKey=BXWNKGSJHAJOGX-UHFFFAOYSA-N
InChI=1S/C16H34O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h17H,2-16H2,1H3

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including: https://www.drugs.com/dict/cetyl-alcohol.html http://www.wikidoc.org/index.php/Cetyl_alcohol http://wisderm.com/ingredients/Cetyl+Alcohol#ref-17

Cetyl alcohol is the 16-carbon alcohol corresponding to palmitic acid, so called because it is isolated from among the hydrolysis products of spermaceti. This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy). Most emollients can be used safely and effectively with no side effects. However, burning, stinging, redness, or irritation may occur. A very serious allergic reaction to this drug is rare.

Originator

Chevreul, M.E.
21
Sources: DOI: 10.1111/j.1478-4408.1890.tb02251.x

Approval Year

1984
98
Targets

Targets

Primary TargetPharmacologyConditionPotency
Fatty aldehyde dehydrogenase
1
Target ID: P51648
Gene ID: 224.0
Gene Symbol: ALDH3A2
Target Organism: Homo sapiens (Human)
Substrate
661
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8429
EXOSURF NEONATAL

Approved Use

Colfosceril, cetyl alcohol, and tyloxapol combination is indicated for the prophylactic treatment of infants with birth weights of less than 1350 grams who are at risk of developing respiratory distress syndrome.

Launch Date

6.4946877E11
Palliative
Approved
8429
ALL DAY SKIN RELIEF WITH COLLOIDAL OATS

Approved Use

Relieves dry, itchy skin and provides hydration.
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer
alcohol dehydrogenase
7
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
alcohol dehydrogenase
7
 yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY551407
https://www.001chemical.com/chem/36653-82-4
3B Scientific (Wuhan) Corp
3B3-033346
http://www.3bsc.com/index/pro_info.php?id=54610
AHH Chemical co.,ltd
MT-49121
http://www.ahhchemical.com/product/MT-49121.html
AK Scientific, Inc. (AKSCI)
69856
http://www.aksci.com/item_detail.php?cat=69856
AbMole Bioscience
M2355
http://www.abmole.com/products/1-hexadecanol.html
Acadechem
ACDS-071659
http://www.acadechemical.com/product/146358
Achemica
ACMC-1AJXA
http://www.achemica.com/prodinfo/?id=113849
Acros Organics
AC120480100
https://www.fishersci.com/shop/products/1-hexadecanol-96-acros-organics-3/AC120480100
Acros Organics
AC120480010
https://www.fishersci.com/shop/products/1-hexadecanol-96-acros-organics/AC120480010
Acros Organics
AC120480025
https://www.fishersci.com/shop/products/1-hexadecanol-96-acros-organics/AC120480025
Alfa Aesar
A11180
https://www.alfa.com/en/catalog/A11180/
Alfa Chemistry
ACM36653824
https://lipids.alfa-chemistry.com/product/hexadecanol-cas-36653-82-4-307386.html
Alfa Chemistry
AP36653824
https://reagents.alfa-chemistry.com/product/cetyl-alcohol-cas-36653-82-4-10687.html
Alichem
490017068
http://www.alichem.com/en/products/36653-82-4.html
Angene
AGN-PC-0WAJ6C
http://www.angenechemical.com/productshow/AGN-PC-0WAJ6C.html
Anward
ANW-28459
http://www.anward.com/pro_result/2540
ApexBio Technology
B1651
http://www.apexbt.com/1-hexadecanol.html
Aronis
ARONIS25150
http://www.aronis.ru/store/index.php?main_page=product_info&cPath=1&products_id=18046
Aurora Fine Chemicals LLC
K02.101.449
http://online.aurorafinechemicals.com/info?ID=K02.101.449
Aurum Pharmatech LLC
NE10353
http://www.Aurumpharmatech.com/Product/ProductDetails/NE10353
Avantor Inc
BJ03884-500G
https://us.vwr.com/store/product/25947408/1-hexadecanol-cetyl-alcohol-tested-according-to-ph-eur-riedel-de-haentm
Avantor Inc
200008-680
https://us.vwr.com/store/product/7514430/1-hexadecanol-cetyl-alcohol-96
Avantor Inc
470300-686
https://us.vwr.com/store/product/8869497/cetyl-alcohol
BLD Pharm
BD58705
http://www.bldpharm.com/products/36653-82-4.html
BOC Sciences
284474-73-3
https://www.bocsci.com/1-hexadecan-d33-ol-cas-284474-73-3-item-79338.html
BOC Sciences
203633-15-2
https://www.bocsci.com/n-hexadecanol-2-2-3-3-16-16-16-d31-cas-203633-15-2-item-79122.html
BOC Sciences
75736-52-6
https://www.bocsci.com/n-hexadecyl-16-16-16-d3-alcohol-cas-75736-52-6-item-79243.html
BioCrick
BCC4616
http://www.biocrick.com/1-Hexadecanol-BCC4616.html
CSNpharm
CSN25536
https://www.csnpharm.com/products/1-hexadecanol.html
Chem Scene
CS-D1348
http://www.chemscene.com/36653-82-4.html
ChemMol
99075020
http://www.chemmol.com/chemmol/99075020.html
ChemMol
99099734
http://www.chemmol.com/chemmol/99099734.html
Chemspace
CSSB00000610633
https://chem-space.com/CSSB00000610633
Clearsynth
CS-EG-00309
https://www.clearsynth.com/en/CSEG00309.html
Clearsynth
CS-ER-02595
https://www.clearsynth.com/en/CSER02595.html
Finetech
FT-0701357
http://www.finetechnology-ind.com/prod/detail/pub/36653-82-4.html
Finetech
FT-0707360
http://www.finetechnology-ind.com/prod/detail/pub/36653-82-4.html
Hairui
HR125172
http://www.hairuichem.com/en/product/36653-82-4.html
LGC Standards
DRE-C14192500
https://www.lgcstandards.com/US/en/p/DRE-C14192500
Lab Network
LN00195823
https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00195823
Matrix Scientific
94644
https://www.matrixscientific.com/094644.html
MedChem Express
HY-B1465
https://www.medchemexpress.com/1-hexadecanol.html
Molcore
MC551407
https://www.molcore.com/product/36653-82-4
Oakwood
225485
http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=106484&ExtHyperLink=1
Parchem
1665
http://www.parchem.com/chemical-supplier-distributor/Cetyl-Alcohol-003052.aspx
Parchem
8280
http://www.parchem.com/chemical-supplier-distributor/hexadecanol-010192.aspx
Parchem
56707
https://www.parchem.com/chemical-supplier-distributor/Cetyl-Alcohol-056707.aspx
Sigma-Aldrich
258741_ALDRICH
https://www.sigmaaldrich.com/catalog/product/aldrich/258741?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
05-2510_SAJ
https://www.sigmaaldrich.com/catalog/product/saj/052510?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
52238_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/52238?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
52240_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/52240?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
1103003_USP
https://www.sigmaaldrich.com/catalog/product/usp/1103003?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech
S056002
http://www.sinfoobiotech.com/product/1059400
Smolecule
S562403
https://www.smolecule.com/products/s562403
TCI (Tokyo Chemical Industry)
H0071
http://www.tcichemicals.com/eshop/en/us/commodity/H0071/index.html
THE BioTek
bt-308538
https://www.thebiotek.com/product/others/bt-308538
VladaChem
VL162191
https://www.vladachem.com/product.php?products=36653-82-4
abcr GmbH
AB117000
http://www.abcr.com/shop/en/AB117000
eNovation Chemicals
D409374
http://www.enovationchem.com/productDetails.asp?productID=D409374
iChemical
EBD2204285
http://www.ichemical.com/products/36653-82-4.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
mcule
MCULE-9457426256
https://mcule.com/MCULE-9457426256/
PubMed

PubMed

TitleDatePubMed
Sjögren-Larsson syndrome: accumulation of free fatty alcohols in cultured fibroblasts and plasma.
2000 Jul
Biodegradation of long-chain n-paraffins from waste oil of car engine by Acinetobacter sp.
2001
Solvent effect on ion-pair extraction of 2-(2-pyridylazo)-1-naphthol-4-sulfonate anion with solvated hydroxonium ion using alcohols and 1-octanol/octane mixed solvents.
2001 Feb
Recombinant chemosensory protein (CSP2) from the moth Mamestra brassicae: crystallization and preliminary crystallographic study.
2001 Jan
[Isolation and identification of chemical constituents from Acropora pulchra].
2001 Sep
Rapid synthesis and turnover of brain microsomal ether phospholipids in the adult rat.
2002 Jan
[Coprecipitation of the Pseudomonas fluorescens lipase with hydrophobic compounds as an approach to its immobilization for catalysis in nonaqueous media].
2002 Jan-Feb
In situ blood-brain barrier transport of nanoparticles.
2003 Nov
A new triterpenoid from Entodon okamurae Broth.
2003 Sep
[Production of surfactants by Rhodococcus erythropolis strain EK-1, grown on hydrophilic and hydrophobic substrates].
2004 Sep-Oct
Blood compatibility of cetyl alcohol/polysorbate-based nanoparticles.
2005 Nov
Displacement of sterols from sterol/sphingomyelin domains in fluid bilayer membranes by competing molecules.
2005 Sep 15
Interfacial rheology and structure of straight-chain and branched fatty alcohol mixtures.
2006 Jun 6
Zeolite-catalyzed Helferich-type glycosylation of long-chain alcohols. Synthesis of acetylated alkyl 1,2-trans glycopyranosides and alkyl 1,2-cis C2-hydroxy-glycopyranosides.
2007 Apr 9
Putative chemical signals about sex, individuality, and genetic background in the preputial gland and urine of the house mouse (Mus musculus).
2007 Mar
Bovine serum albumin-sugar conjugates through the maillard reaction: effects on interfacial behavior and emulsifying ability.
2008
Formulation of sustained-release verapamil HCl and diltiazem HCl semisolid matrix capsules.
2008
Mechanical properties of hexadecane-water interfaces with adsorbed hydrophobic bacteria.
2008 Apr 1
Social bacteria and asocial eukaryotes.
2008 Feb
Substrate specificity of a long-chain alkylamine-degrading Pseudomonas sp isolated from activated sludge.
2008 Feb
Enhanced sorption of polycyclic aromatic hydrocarbons to tetra-alkyl ammonium modified smectites via cation-pi interactions.
2008 Feb 15
Does the solid-liquid crystal phase transition provoke the spin-state change in spin-crossover metallomesogens?
2008 Jan 30
Hydrophobic bacteria at the hexadecane-water interface: examination of micrometre-scale interfacial properties.
2008 Nov 15
Chemistry of the cephalic labial gland secretions of male Bombus morrisoni and B. rufocinctus, two North American bumblebee males with perching behavior.
2008 Oct
Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat.
2008 Sep
Patents

Patents

US 2509171
1
US 3018308
1

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Suspension: 13.5 mg of colfosceril palmitate, 1.5 mg of cetyl alcohol, and 1 mg of tyloxapol per mL, when reconstituted with 8 mL of Sterile Water for Injection supplied by manufacturer
5 mL of reconstituted suspension per kg of body weight administered (in two half-doses) as soon as possible after diagnosis of respiratory distress syndrome (RDS) is confirmed; a second dose (given in two half-doses) should be administered approximately twelve hours after the first dose, provided that the infant remains on mechanical ventilation.
Route of Administration: Intratracheal
In Vitro Use Guide
Unknown
Name Type Language
CETYL ALCOHOL
EP   HSDB   II   INCI   MART.   MI   USP-RS   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
CETYL ALCOHOL [MART.]
Common Name English
FEMA NO. 2554
Code English
CETYL ALCOHOL [USP-RS]
Common Name English
CETYL ALCOHOL [MI]
Common Name English
N-1-HEXADECANOL
Common Name English
HEXADECANOL
Systematic Name English
CETYL ALCHOL
Common Name English
CETYL ALCOHOL [EP MONOGRAPH]
Common Name English
PALMITIC ALCOHOL
Common Name English
CETYL ALCOHOL [VANDF]
Common Name English
NSC-4194
Code English
HEXADECYL ALCOHOL
Systematic Name English
ALCOHOL CETYLICUS [WHO-IP LATIN]
Common Name English
CETYL ALCOHOL [WHO-IP]
Common Name English
Cetyl alcohol [WHO-DD]
Common Name English
PALMITYL ALCOHOL
Systematic Name English
CETANOL
JAN  
Systematic Name English
CETYL ALCOHOL [INCI]
Common Name English
1-HEXADECANOL [FHFI]
Common Name English
CETYL ALCOHOL [II]
Common Name English
N-HEXADECANOL
Common Name English
CETYL ALCOHOL [HSDB]
Common Name English
CETANOL [JAN]
Common Name English
1-Hexadecanol
FHFI  
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C218
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
FDA ORPHAN DRUG 68492
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
FDA ORPHAN DRUG 14886
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
JECFA EVALUATION 1-HEXADECANOL
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
CFR 21 CFR 172.515
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
EPA PESTICIDE CODE 1508
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
Code System Code Type Description
CHEBI
16125
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
DRUG BANK
DB09494
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
SMS_ID
100000078547
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
NCI_THESAURUS
C47442
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
RS_ITEM_NUM
1103003
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
EVMPD
SUB12479MIG
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
CAS
124-29-8
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
ALTERNATIVE
JECFA MONOGRAPH
255
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
MESH
C005031
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
NSC
4194
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
PUBCHEM
2682
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
ECHA (EC/EINECS)
253-149-0
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
HSDB
2643
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
RXCUI
20615
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY RxNorm
MERCK INDEX
m3297
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY Merck Index
EPA CompTox
DTXSID4027991
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
WIKIPEDIA
CETYL ALCOHOL
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
FDA UNII
936JST6JCN
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
ChEMBL
CHEMBL706
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
DRUG CENTRAL
4750
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
CETYL ALCOHOL
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY Description: Unctuous, colourless flakes or a white, crystalline mass; odour, faint and characteristic. Solubility: Practically insoluble in water; soluble in ethanol (~750 g/l) TS and ether R. Category: Emulsifying agent; viscosity-increasing agent. Storage: Cetyl alcohol should be kept in a well-closed container. Definition: Cetyl alcohol is a mixture of solid alcohols consisting mainly of 1-hexadecanol (C16H34O).
CAS
36653-82-4
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
DAILYMED
936JST6JCN
Created by admin on Fri Dec 15 15:04:52 UTC 2023 , Edited by admin on Fri Dec 15 15:04:52 UTC 2023
PRIMARY
ACTIVE MOIETY
Structure of CETYL ALCOHOL
NIH
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