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Description
Curator's Comment:: description was created based on several sources, including: http://www.drugfuture.com/chemdata/Aconitic-Acid.html http://www.accessdata.fda.gov/spl/data/c8b036c1-1366-4707-8f26-5778fc3335b7/c8b036c1-1366-4707-8f26-5778fc3335b7.xml

Aconitic Acid found in leaves and tubers of Aconitum napellus L., Ranunculaceae, in various species of Achillea (Compositae) and Equisetum (Equisetaceae), in beet root, and in sugar cane. It is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution. The limited data on trans-aconitic acid indicate it to be less toxic than citric acid. Trans-aconitate salts appear to be excreted readily by the kidneys. There is no direct evidence that trans-aconitic acid is utilized as is the cis-aconitic acid isomer in mammalian metabolism although non-specific oxidation probably occurs.

Originator

Sources: DOI: 10.1002/jlac.18751780203
Curator's Comment:: McCalip, M.A., Seibert, A.H. DOI: 10.1021/ie50377a019

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
IMMUNO-BOOST

Approved Use

GRAS. Homeopathic drug is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution.
Palliative
IMMUNO-BOOST

Approved Use

GRAS. Homeopathic drug is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution.
Palliative
IMMUNO-BOOST

Approved Use

GRAS. Homeopathic drug is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution.
PubMed

PubMed

TitleDatePubMed
Fatal lactic acidosis in a newborn attributable to a congenital defect of pyruvate dehydrogenase.
1976 Jan
Abnormal carbohydrate metabolism in cerebrospinal fluid in Rett syndrome.
1994 Jan
Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.
1994 Jun
Antiviral effects of milk proteins: acylation results in polyanionic compounds with potent activity against human immunodeficiency virus types 1 and 2 in vitro.
1996 Jun 10
Lactoferrin. Antiviral activity of lactoferrin.
1998
Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients.
1998
Charge modification of plasma and milk proteins results in antiviral active compounds.
1999 Dec
Organic acids in the second morning urine in a healthy Swiss paediatric population.
2003 Dec
Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles.
2011 Aug
Patents

Sample Use Guides

10 drops under the tongue, 3 to 6 times per day
Route of Administration: Oral
In Vitro Use Guide
10-30 ug/ml of trans-aconitic acid inhibits TNF-α release in LPS-stimulated THP-1 cells up to75%
Name Type Language
ACONITIC ACID
FCC   FHFI   HSDB   MI  
Common Name English
ACONITIC ACID [FCC]
Common Name English
CITRIDIC ACID
Common Name English
PROPENE-1,2,3-TRICARBOXYLIC ACID
Common Name English
1,2,3-PROPENETRICARBOXYLIC ACID
Common Name English
NSC-7616
Code English
1-PROPENE-1,2,3-TRICARBOXYLIC ACID
Common Name English
ACONITIC ACID [HSDB]
Common Name English
ACONITIC ACID [MI]
Common Name English
ACHILLEIC ACID
Common Name English
FEMA NO. 2010
Code English
ACONITATE
Common Name English
EQUISETIC ACID
Common Name English
ACONITIC ACID [FHFI]
Common Name English
Classification Tree Code System Code
LOINC 43622-0
Created by admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
LOINC 26832-6
Created by admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
LOINC 29525-3
Created by admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
CFR 21 CFR 184.1007
Created by admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
JECFA EVALUATION ACONITIC ACID
Created by admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
LOINC 75083-6
Created by admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
LOINC 13702-6
Created by admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
Code System Code Type Description
MERCK INDEX
M1379
Created by admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
PRIMARY Merck Index
HSDB
635
Created by admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
PRIMARY
ECHA (EC/EINECS)
207-877-0
Created by admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
PRIMARY
EPA CompTox
499-12-7
Created by admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
PRIMARY
RXCUI
1721299
Created by admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
ALTERNATIVE
CAS
499-12-7
Created by admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
PRIMARY
WIKIPEDIA
ACONITIC ACID
Created by admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
PRIMARY
RXCUI
1721298
Created by admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
PRIMARY RxNorm
Any of these components may be present:
Definition References