U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Description
Curator's Comment: description was created based on several sources, including: http://www.drugfuture.com/chemdata/Aconitic-Acid.html http://www.accessdata.fda.gov/spl/data/c8b036c1-1366-4707-8f26-5778fc3335b7/c8b036c1-1366-4707-8f26-5778fc3335b7.xml

Aconitic Acid found in leaves and tubers of Aconitum napellus L., Ranunculaceae, in various species of Achillea (Compositae) and Equisetum (Equisetaceae), in beet root, and in sugar cane. It is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution. The limited data on trans-aconitic acid indicate it to be less toxic than citric acid. Trans-aconitate salts appear to be excreted readily by the kidneys. There is no direct evidence that trans-aconitic acid is utilized as is the cis-aconitic acid isomer in mammalian metabolism although non-specific oxidation probably occurs.

Originator

Sources: DOI: 10.1002/jlac.18751780203
Curator's Comment: McCalip, M.A., Seibert, A.H. DOI: 10.1021/ie50377a019

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
IMMUNO-BOOST

Approved Use

GRAS. Homeopathic drug is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution.
Palliative
IMMUNO-BOOST

Approved Use

GRAS. Homeopathic drug is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution.
Palliative
IMMUNO-BOOST

Approved Use

GRAS. Homeopathic drug is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution.
PubMed

PubMed

TitleDatePubMed
Abnormal carbohydrate metabolism in cerebrospinal fluid in Rett syndrome.
1994 Jan
Patents

Sample Use Guides

10 drops under the tongue, 3 to 6 times per day
Route of Administration: Oral
In Vitro Use Guide
10-30 ug/ml of trans-aconitic acid inhibits TNF-α release in LPS-stimulated THP-1 cells up to75%
Name Type Language
ACONITIC ACID
FCC   FHFI   HSDB   MI  
Common Name English
ACONITIC ACID [FCC]
Common Name English
CITRIDIC ACID
Common Name English
PROPENE-1,2,3-TRICARBOXYLIC ACID
Common Name English
1,2,3-PROPENETRICARBOXYLIC ACID
Common Name English
NSC-7616
Code English
1-PROPENE-1,2,3-TRICARBOXYLIC ACID
Common Name English
ACONITIC ACID [HSDB]
Common Name English
ACONITIC ACID [MI]
Common Name English
ACHILLEIC ACID
Common Name English
FEMA NO. 2010
Code English
ACONITATE
Common Name English
EQUISETIC ACID
Common Name English
ACONITIC ACID [FHFI]
Common Name English
Classification Tree Code System Code
LOINC 43622-0
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
LOINC 26832-6
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
LOINC 29525-3
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
CFR 21 CFR 184.1007
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
JECFA EVALUATION ACONITIC ACID
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
LOINC 75083-6
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
LOINC 13702-6
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
Code System Code Type Description
MERCK INDEX
m1379
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
PRIMARY Merck Index
FDA UNII
93371T1BXP
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
PRIMARY
HSDB
635
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
PRIMARY
ECHA (EC/EINECS)
207-877-0
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
PRIMARY
EPA CompTox
DTXSID9060102
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
PRIMARY
RXCUI
1721299
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
ALTERNATIVE
DAILYMED
93371T1BXP
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
PRIMARY
CAS
499-12-7
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
PRIMARY
WIKIPEDIA
ACONITIC ACID
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
PRIMARY
CHEBI
22211
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
PRIMARY
JECFA MONOGRAPH
1120
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
PRIMARY
RXCUI
1721298
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
PRIMARY RxNorm
NSC
7616
Created by admin on Fri Dec 15 17:03:55 GMT 2023 , Edited by admin on Fri Dec 15 17:03:55 GMT 2023
PRIMARY
Any of these components may be present:
Definition References