DescriptionCurator's Comment:: description was created based on several sources, including:
http://www.drugfuture.com/chemdata/Aconitic-Acid.html
http://www.accessdata.fda.gov/spl/data/c8b036c1-1366-4707-8f26-5778fc3335b7/c8b036c1-1366-4707-8f26-5778fc3335b7.xml
Curator's Comment:: description was created based on several sources, including:
http://www.drugfuture.com/chemdata/Aconitic-Acid.html
http://www.accessdata.fda.gov/spl/data/c8b036c1-1366-4707-8f26-5778fc3335b7/c8b036c1-1366-4707-8f26-5778fc3335b7.xml
Aconitic Acid found in leaves and tubers of Aconitum napellus L., Ranunculaceae, in various species of Achillea (Compositae) and Equisetum (Equisetaceae), in beet root, and in sugar cane. It is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution. The limited data on trans-aconitic acid indicate it to be less toxic than citric acid. Trans-aconitate salts appear to be excreted readily by the kidneys. There is no direct evidence that trans-aconitic acid is utilized as is the cis-aconitic acid isomer in mammalian metabolism although non-specific oxidation probably occurs.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL4612 Sources: http://www.ncbi.nlm.nih.gov/pubmed/924365 |
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Target ID: GO:0006979 Sources: http://www.ncbi.nlm.nih.gov/pubmed/27507497 |
70.0 mM [IC50] | ||
Target ID: 730249.0 Gene Symbol: ACOD1 |
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Target ID: P21399 Gene ID: 48.0 Gene Symbol: ACO1 Target Organism: Homo sapiens (Human) |
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Target ID: CHEMBL367 |
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Target ID: Aconitase |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Palliative | IMMUNO-BOOST Approved UseGRAS. Homeopathic drug is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution. |
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Palliative | IMMUNO-BOOST Approved UseGRAS. Homeopathic drug is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution. |
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Palliative | IMMUNO-BOOST Approved UseGRAS. Homeopathic drug is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution. |
PubMed
Title | Date | PubMed |
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Age-related reference values for urinary organic acids in a healthy Turkish pediatric population. | 1994 Jun |
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Antiviral effects of milk proteins: acylation results in polyanionic compounds with potent activity against human immunodeficiency virus types 1 and 2 in vitro. | 1996 Jun 10 |
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Lactoferrin. Antiviral activity of lactoferrin. | 1998 |
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Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients. | 1998 |
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Organic acids in the second morning urine in a healthy Swiss paediatric population. | 2003 Dec |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/26692456
10-30 ug/ml of trans-aconitic acid inhibits TNF-α release in LPS-stimulated THP-1 cells up to75%
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Classification Tree | Code System | Code | ||
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LOINC |
43622-0
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LOINC |
26832-6
Created by
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LOINC |
29525-3
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CFR |
21 CFR 184.1007
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JECFA EVALUATION |
ACONITIC ACID
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LOINC |
75083-6
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LOINC |
13702-6
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Code System | Code | Type | Description | ||
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M1379
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PRIMARY | Merck Index | ||
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635
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PRIMARY | |||
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207-877-0
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PRIMARY | |||
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499-12-7
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PRIMARY | |||
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1721299
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admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
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499-12-7
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ACONITIC ACID
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1721298
Created by
admin on Sun Jun 27 00:03:55 UTC 2021 , Edited by admin on Sun Jun 27 00:03:55 UTC 2021
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PRIMARY | RxNorm |
Any of these components may be present:
SUBSTANCE RECORD