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Description

Aconitic Acid found in leaves and tubers of Aconitum napellus L., Ranunculaceae, in various species of Achillea (Compositae) and Equisetum (Equisetaceae), in beet root, and in sugar cane. It is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution. The limited data on trans-aconitic acid indicate it to be less toxic than citric acid. Trans-aconitate salts appear to be excreted readily by the kidneys. There is no direct evidence that trans-aconitic acid is utilized as is the cis-aconitic acid isomer in mammalian metabolism although non-specific oxidation probably occurs.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
70.0 mM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
IMMUNO-BOOST
Palliative
IMMUNO-BOOST
Palliative
IMMUNO-BOOST

PubMed

Sample Use Guides

In Vivo Use Guide
10 drops under the tongue, 3 to 6 times per day
Route of Administration: Oral
In Vitro Use Guide
10-30 ug/ml of trans-aconitic acid inhibits TNF-α release in LPS-stimulated THP-1 cells up to75%
Substance Class Mixture
Record UNII
93371T1BXP
Record Status Validated (UNII)
Record Version
Any of these components may be present:
Definition References