DescriptionCurator's Comment: description was created based on several sources, including:
http://www.drugfuture.com/chemdata/Aconitic-Acid.html
http://www.accessdata.fda.gov/spl/data/c8b036c1-1366-4707-8f26-5778fc3335b7/c8b036c1-1366-4707-8f26-5778fc3335b7.xml
Curator's Comment: description was created based on several sources, including:
http://www.drugfuture.com/chemdata/Aconitic-Acid.html
http://www.accessdata.fda.gov/spl/data/c8b036c1-1366-4707-8f26-5778fc3335b7/c8b036c1-1366-4707-8f26-5778fc3335b7.xml
Aconitic Acid found in leaves and tubers of Aconitum napellus L., Ranunculaceae, in various species of Achillea (Compositae) and Equisetum (Equisetaceae), in beet root, and in sugar cane. It is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution. The limited data on trans-aconitic acid indicate it to be less toxic than citric acid. Trans-aconitate salts appear to be excreted readily by the kidneys. There is no direct evidence that trans-aconitic acid is utilized as is the cis-aconitic acid isomer in mammalian metabolism although non-specific oxidation probably occurs.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL4612 Sources: http://www.ncbi.nlm.nih.gov/pubmed/924365 |
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Target ID: GO:0006979 Sources: http://www.ncbi.nlm.nih.gov/pubmed/27507497 |
70.0 mM [IC50] | ||
Target ID: 730249.0 Gene Symbol: ACOD1 |
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Target ID: P21399 Gene ID: 48.0 Gene Symbol: ACO1 Target Organism: Homo sapiens (Human) |
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Target ID: CHEMBL367 |
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Target ID: Aconitase |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Palliative | IMMUNO-BOOST Approved UseGRAS. Homeopathic drug is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution. |
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Palliative | IMMUNO-BOOST Approved UseGRAS. Homeopathic drug is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution. |
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Palliative | IMMUNO-BOOST Approved UseGRAS. Homeopathic drug is indicated for the temporary relief of symptoms of chronic illness including fatigue, effects of toxin buildup, slowed metabolism, weakened constitution. |
PubMed
Title | Date | PubMed |
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Fatal lactic acidosis in a newborn attributable to a congenital defect of pyruvate dehydrogenase. | 1976 Jan |
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Abnormal carbohydrate metabolism in cerebrospinal fluid in Rett syndrome. | 1994 Jan |
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Lactoferrin. Antiviral activity of lactoferrin. | 1998 |
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Charge modification of plasma and milk proteins results in antiviral active compounds. | 1999 Dec |
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Organic acids in the second morning urine in a healthy Swiss paediatric population. | 2003 Dec |
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Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles. | 2011 Aug |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/26692456
10-30 ug/ml of trans-aconitic acid inhibits TNF-α release in LPS-stimulated THP-1 cells up to75%
Substance Class |
Mixture
Created
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Record UNII |
93371T1BXP
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Record Status |
Validated (UNII)
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Record Version |
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LOINC |
43622-0
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LOINC |
26832-6
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LOINC |
29525-3
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CFR |
21 CFR 184.1007
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JECFA EVALUATION |
ACONITIC ACID
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LOINC |
75083-6
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LOINC |
13702-6
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m1379
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93371T1BXP
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635
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207-877-0
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DTXSID9060102
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1721299
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93371T1BXP
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499-12-7
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ACONITIC ACID
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22211
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1120
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1721298
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7616
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