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Details

Stereochemistry ACHIRAL
Molecular Formula CH4N2O
Molecular Weight 60.0553
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of UREA

SMILES

NC(N)=O

InChI

InChIKey=XSQUKJJJFZCRTK-UHFFFAOYSA-N
InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)

HIDE SMILES / InChI

Description

Pastaron (Urea) is a waste product of many living organisms, and is the major organic component of human urine. It is a very important starting material in a number of chemical syntheses, and is used on an industrial scale for the manufacture of fertilizers, pharmaceuticals, and resins. Urea is an osmotic diuretic similar to mannitol but more irritant. Applied topically, urea promotes hydration of keratin and mild keratolysis in dry skin. It increases water uptake by the stratum corneum and has an antipruritic effect. Pastaron is used to soften rough or dry skin caused by skin conditions such as eczema, psoriasis, keratosis, and others.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
UREAPHIL
Palliative
UREAPHIL
Palliative
UREAPHIL

PubMed

Sample Use Guides

In Vivo Use Guide
Applied to the affected area one or several times a day.
Route of Administration: Topical
In Vitro Use Guide
Endometrial explants were cultured and treated with 0, 4, 8, 12, 16 mM of urea. Relative FGF2 gene expression was less in explants treated with a greater concentration of urea (16mM) when compared with lesser concentrations. Expression of HSPA1A, IGFBP3, and SERPINA14 genes was greater in explants exposed to lesser concentrations of urea (4mM). Greater concentrations of urea have negative effects on some endometrial gene expression, while moderate concentrations have positive effects.