Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C27H22F4N4O3S.ClH |
| Molecular Weight | 595.008 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.FC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=O)C3=CC=C(NC4=C5C=CC(=CC5=NC=C4)C(F)(F)F)C=C3
InChI
InChIKey=MGOGSSZOPFFXLA-UHFFFAOYSA-N
InChI=1S/C27H22F4N4O3S.ClH/c28-20-4-8-22(9-5-20)39(37,38)35-15-13-34(14-16-35)26(36)18-1-6-21(7-2-18)33-24-11-12-32-25-17-19(27(29,30)31)3-10-23(24)25;/h1-12,17H,13-16H2,(H,32,33);1H
Losulazine (U-54,669F) is an antihypertensive agent acting by a sympatholytic mechanism. It appears to alter peripheral sympathetic neurogenic function but apparently does not enter the central nervous system. Losulazine effectively lowered the blood pressure in patients with hypertension.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Study on the activities of testes and accessory sex glands after losulazine treatment in rats. | 1994-09 |
|
| Comparison of the effects of losulazine and reserpine on central aminergic neurons. | 1993-11 |
|
| Mechanism of anestrus in rats treated with an antihypertensive agent, losulazine hydrochloride. | 1987-01 |
|
| 7-(Trifluoromethyl)-4-aminoquinoline hypotensives: novel peripheral sympatholytics. | 1986-01 |
|
| Losulazine, a new antihypertensive. | 1985-08 |
Patents
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|---|---|---|---|---|
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Official Name | English | ||
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Preferred Name | English | ||
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Common Name | English | ||
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Systematic Name | English | ||
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Code | English |
| Code System | Code | Type | Description | ||
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C175117
Created by
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T-96
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CHEMBL287419
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300000055233
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DTXSID50231105
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81435-67-8
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C036654
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8PK0TPX321
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54749
Created by
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PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
