Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C12H18IN.ClH |
| Molecular Weight | 339.643 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC(C)NC(C)CC1=CC=C(I)C=C1
InChI
InChIKey=AFLDFEASYWNJGX-UHFFFAOYSA-N
InChI=1S/C12H18IN.ClH/c1-9(2)14-10(3)8-11-4-6-12(13)7-5-11;/h4-7,9-10,14H,8H2,1-3H3;1H
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Validation of CBF measurement with non-invasive microsphere method (NIMS) compared with autoradiography method (ARG). | 2001 Feb |
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| [Paradoxical embolism with Chiari network, subsequently being accompanied by probable incomplete infarction: a case report]. | 2001 Feb-Mar |
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| Redistribution in I-123 N-isopropyl-p iodoamphetamine single-photon emission computed tomography in cerebrovascular disease and the effects of rehabilitation. | 2001 Jun |
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| The norepinephrine precursor L-threo-3,4-dihydroxyphenylserine facilitates motor recovery in chronic stroke patients. | 2001 Nov |
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| Optimal inversion time for acquiring flow-sensitive alternating inversion recovery images to quantify regional cerebral blood flow. | 2002 Dec |
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| Regional differences in distribution volume of I-123 IMP in the human brain: effect on CBF calculated by ARG method. | 2002 Jul |
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| I-123 IMP pulmonary SPECT in a patient with acute pulmonary thromboembolism. | 2002 Jun |
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| Quantitative measurement of regional cerebral blood flow with flow-sensitive alternating inversion recovery imaging: comparison with [iodine 123]-iodoamphetamin single photon emission CT. | 2002 Mar |
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| [A practice of various quantitative methods for cerebral blood flow using brain SPECT--notes in clinical application]. | 2002 May |
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| Interobserver variation in diagnosis of dementia by brain perfusion SPECT. | 2002 Nov-Dec |
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| Decreased cerebral blood flow in renal transplant recipients. | 2002 Sep |
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| Detection of misery perfusion with split-dose 123I-iodoamphetamine single-photon emission computed tomography in patients with carotid occlusive diseases. | 2002 Sep |
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| Rectal malignant melanoma diagnosed by N-isopropyl- p-123I-iodoamphetamine single photon emission computed tomography and 5-S-cysteinyl dopa: report of a case. | 2003 |
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| Quantitative measurement of regional cerebrovascular reactivity to acetazolamide using 123I-N-isopropyl-p-iodoamphetamine autoradiography with SPECT: validation study using H2 15O with PET. | 2003 Apr |
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| [Chronological changes in the vasculature and the cerebral blood flow of two patients with isolated angiitis of the central nervous system]. | 2003 Aug |
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| High 123I-IMP retention on SPECT image in primary central nervous system lymphoma. | 2003 Feb |
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| [The development of new method for the assessment of perfusion reserve using split dose iodine-123-IMP SPECT: one-day protocol by modified ARG method]. | 2003 May |
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| Cerebral hemodynamics and metabolism in adult moyamoya disease: comparison of angiographic collateral circulation. | 2004 Apr |
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| A case of intravascular lymphoma with increased regional cerebral blood flow in I-123 IMP single-photon emission CT. | 2004 Apr |
|
| Chronic subdural hematoma following dural metastasis of gastric cancer: measurement of pre- and postoperative cerebral blood flow with N-isopropyl-p-[123I]iodoamphetamine--case report. | 2004 Dec |
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| [Changes in visual event-related potentials and SPECT in dissociative amnesia]. | 2004 Jan |
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| Therapeutic effect and [123I]IMP SPECT findings of sodium dichloroacetate in a patient with MELAS. | 2004 Jan 27 |
|
| Comparison of FDG-PET and IMP-SPECT in patients with dementia with Lewy bodies. | 2004 Jul |
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| Assessment of cerebral hemodynamics in childhood moyamoya disease using a quantitative and a semiquantitative IMP-SPECT study. | 2004 Jun |
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| [Diagnosis of dementia and neurodegenerative disorders by brain SPECT of three dimensional stereotactic surface projection method]. | 2004 Mar |
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| A simple method for the detection of abnormal brain regions in Alzheimer's disease patients using [11C]MP4A: comparison with [123I]IMP SPECT. | 2004 May |
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| Cerebral blood flow in Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease according to three-dimensional stereotactic surface projection imaging. | 2005 |
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| Brain 3D-SSP SPECT analysis in dementia with Lewy bodies, Parkinson's disease with and without dementia, and Alzheimer's disease. | 2005 Aug |
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| [Two surgically treated cases with dural arteriovenous malformation in the anterior cranial fossa]. | 2005 Dec |
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| Perfusion CT investigation of chronic internal carotid artery occlusion: comparison with SPECT. | 2005 Dec |
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| Increased accumulations of N-isopropyl-p-[123I]-iodoamphetamine related to tumefactive multiple sclerosis. | 2005 Oct |
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| [Single photon emission computed tomography findings in a case of alternating hemiplegia of childhood in relation to migraine]. | 2005 Sep |
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| Brain and whole body distribution of N-isopropyl-4-iodoamphetamine (I-123) in humans: comparison of radiopharmaceuticals marketed by different companies in Japan. | 2006 Aug |
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| [Diagnostic value of perfusion-weighted MRI for evaluating postoperative alteration of cerebral hemodynamics following STA-MCA anastomosis in patients with moyamoya disease]. | 2006 Aug |
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| Hypoperfusion of the visual pathway in parkinsonian patients with visual hallucinations. | 2006 Dec |
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| Hypoperfusion of the auditory and prefrontal cortices in Parkinsonian patients with verbal hallucinations. | 2006 Dec |
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| Database of normal human cerebral blood flow measured by SPECT: II. Quantification of I-123-IMP studies with ARG method and effects of partial volume correction. | 2006 Feb |
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| [Correlation of the cognitive function and the duration of the illness with the regional cerebral blood flow in the patients with Parkinson's disease: objective evaluation using stereotactic extraction estimation analysis in 123I-IMP SPECT]. | 2006 Jan |
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| Comparative value of brain perfusion SPECT and [(123)I]MIBG myocardial scintigraphy in distinguishing between dementia with Lewy bodies and Alzheimer's disease. | 2006 Mar |
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| Diagnosis of atypical choroidal malignant melanoma using N-isopropyl-p-[123I]-iodoamphetamine single photon emission computed tomography. | 2006 Mar-Apr |
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| Measurement of regional cerebral blood flow with 123I-IMP using one-point venous blood sampling and causality analysis: evaluation by comparison with conventional continuous arterial blood sampling. | 2006 Nov |
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| Pre-surgical identification of epileptogenic areas in temporal lobe epilepsy by 123I-iomazenil SPECT: a comparison with IMP SPECT and FDG PET. | 2006 Nov |
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| [A case of ticlopidine-associated thrombotic thrombocytopenic purpura: special emphasis on diffusion weighted MRI]. | 2006 Oct |
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| Regional cerebral blood flow and developmental outcome in cryptogenic West syndrome. | 2007 Jan |
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| Symptomatic hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in a child with moyamoya disease. | 2007 Oct |
Patents
Sample Use Guides
The recommended intravenous dose for SPECTAMINE (lofetamine HCI I-123 Injection) in the average adult patient (70 kg) is 111 to 222 megabecquerels (3 to 6 millicuries).
Route of Administration:
Intravenous
Cerebral tissue was taken from six-day-old Wistar rat pups. Twenty-four explants were cut from the occipital cortex of a single animal and grown in pairs on polyamide carrier grids distributed over 12 petri. The cultures were incubated with iofetamine (5 uCi) and the drug uptake was tested.
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877DO43251
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DTXSID3045774
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55305
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82691-32-5
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CHEMBL1201308
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PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
