Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C12H18IN.ClH |
| Molecular Weight | 339.643 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC(C)NC(C)CC1=CC=C(I)C=C1
InChI
InChIKey=AFLDFEASYWNJGX-UHFFFAOYSA-N
InChI=1S/C12H18IN.ClH/c1-9(2)14-10(3)8-11-4-6-12(13)7-5-11;/h4-7,9-10,14H,8H2,1-3H3;1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C12H18IN |
| Molecular Weight | 303.1825 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Symptomatic hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in a child with moyamoya disease. | 2007-10 |
|
| Regional cerebral blood flow and developmental outcome in cryptogenic West syndrome. | 2007-01 |
|
| Hypoperfusion of the visual pathway in parkinsonian patients with visual hallucinations. | 2006-12 |
|
| Hypoperfusion of the auditory and prefrontal cortices in Parkinsonian patients with verbal hallucinations. | 2006-12 |
|
| Measurement of regional cerebral blood flow with 123I-IMP using one-point venous blood sampling and causality analysis: evaluation by comparison with conventional continuous arterial blood sampling. | 2006-11 |
|
| Pre-surgical identification of epileptogenic areas in temporal lobe epilepsy by 123I-iomazenil SPECT: a comparison with IMP SPECT and FDG PET. | 2006-11 |
|
| [A case of ticlopidine-associated thrombotic thrombocytopenic purpura: special emphasis on diffusion weighted MRI]. | 2006-10 |
|
| Brain and whole body distribution of N-isopropyl-4-iodoamphetamine (I-123) in humans: comparison of radiopharmaceuticals marketed by different companies in Japan. | 2006-08 |
|
| [Diagnostic value of perfusion-weighted MRI for evaluating postoperative alteration of cerebral hemodynamics following STA-MCA anastomosis in patients with moyamoya disease]. | 2006-08 |
|
| Quantification of the regional cerebral blood flow and vascular reserve in moyamoya disease using split-dose iodoamphetamine I 123 single-photon emission computed tomography. | 2006-08 |
|
| Wisconsin Card Sorting Test and brain perfusion imaging in Parkinson's disease. | 2006-06 |
|
| Alteration of regional cerebral blood flow to thyrotropin-releasing hormone therapy in acute encephalitis and encephalopathy during childhood. | 2006-05 |
|
| Diastolic blood pressure influences cerebrovascular reactivity measured by means of 123I-iodoamphetamine brain single photon emission computed tomography in medically treated patients with occlusive carotid or middle cerebral artery disease. | 2006-04 |
|
| Frontal assessment battery and brain perfusion image in Parkinson's disease. | 2006-03 |
|
| Comparative value of brain perfusion SPECT and [(123)I]MIBG myocardial scintigraphy in distinguishing between dementia with Lewy bodies and Alzheimer's disease. | 2006-03 |
|
| Database of normal human cerebral blood flow measured by SPECT: II. Quantification of I-123-IMP studies with ARG method and effects of partial volume correction. | 2006-02 |
|
| Database of normal human cerebral blood flow measured by SPECT: I. Comparison between I-123-IMP, Tc-99m-HMPAO, and Tc-99m-ECD as referred with O-15 labeled water PET and voxel-based morphometry. | 2006-02 |
|
| Comparative study of cerebral blood flow in patients with normal-tension glaucoma and control subjects. | 2006-02 |
|
| [Correlation of the cognitive function and the duration of the illness with the regional cerebral blood flow in the patients with Parkinson's disease: objective evaluation using stereotactic extraction estimation analysis in 123I-IMP SPECT]. | 2006-01 |
|
| [Two surgically treated cases with dural arteriovenous malformation in the anterior cranial fossa]. | 2005-12 |
|
| Perfusion CT investigation of chronic internal carotid artery occlusion: comparison with SPECT. | 2005-12 |
|
| Increased accumulations of N-isopropyl-p-[123I]-iodoamphetamine related to tumefactive multiple sclerosis. | 2005-10 |
|
| N-isopropyl-p- 123I iodoamphetamine single photon emission computed tomography study of Parkinson's disease with dementia. | 2005-10 |
|
| Three-dimensional stereotactic surface projection study of freezing of gait and brain perfusion image in Parkinson's disease. | 2005-10 |
|
| [SPECT for diagnosis of brain tumors]. | 2005-09 |
|
| [Single photon emission computed tomography findings in a case of alternating hemiplegia of childhood in relation to migraine]. | 2005-09 |
|
| Brain 3D-SSP SPECT analysis in dementia with Lewy bodies, Parkinson's disease with and without dementia, and Alzheimer's disease. | 2005-08 |
|
| Incidentally detected parafalcine chondrosarcoma. | 2005-07 |
|
| Effects of tissue heterogeneity on cerebral vascular response to acetazolamide stress measured by an I-123-IMP autoradiographic method with single-photon emission computed tomography. | 2005-06 |
|
| Diagnosis of Alzheimer's disease using brain perfusion SPECT and MR imaging: which modality achieves better diagnostic accuracy? | 2005-04 |
|
| [Amnesia following left medial frontal subcortical hemorrhage: a case report]. | 2005-03 |
|
| Cerebral blood flow in Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease according to three-dimensional stereotactic surface projection imaging. | 2005 |
|
| Chronic subdural hematoma following dural metastasis of gastric cancer: measurement of pre- and postoperative cerebral blood flow with N-isopropyl-p-[123I]iodoamphetamine--case report. | 2004-12 |
|
| Diagnosis of atypical choroidal malignant melanoma using N-isopropyl-p-[123I]-iodoamphetamine single photon emission computed tomography. | 2004-11-22 |
|
| Losartan, an angiotensin II (AT1) receptor antagonist, preserves cerebral blood flow in hypertensive patients with a history of stroke. | 2004-10 |
|
| Availability of N-isopropyl-p-[125I]iodoamphetamine (IMP) as a practical cerebral blood flow (CBF) indicator in rats. | 2004-08 |
|
| Comparison of FDG-PET and IMP-SPECT in patients with dementia with Lewy bodies. | 2004-07 |
|
| Assessment of cerebral hemodynamics in childhood moyamoya disease using a quantitative and a semiquantitative IMP-SPECT study. | 2004-06 |
|
| Error analysis of measured cerebral vascular response to acetazolamide stress by I-123-IMP autoradiographic method with single photon emission computed tomography: errors due to distribution volume of I-123-IMP. | 2004-05 |
|
| A simple method for the detection of abnormal brain regions in Alzheimer's disease patients using [11C]MP4A: comparison with [123I]IMP SPECT. | 2004-05 |
|
| Cerebral hemodynamics and metabolism in adult moyamoya disease: comparison of angiographic collateral circulation. | 2004-04 |
|
| Clinical efficacy of 123I-IMP SPECT for the diagnosis of malignant uveal melanoma. | 2004-04 |
|
| A case of intravascular lymphoma with increased regional cerebral blood flow in I-123 IMP single-photon emission CT. | 2004-04 |
|
| [Diagnosis of dementia and neurodegenerative disorders by brain SPECT of three dimensional stereotactic surface projection method]. | 2004-03 |
|
| Crossed cerebellar diaschisis in patients with cortical infarction: logistic regression analysis to control for confounding effects. | 2004-02 |
|
| Therapeutic effect and [123I]IMP SPECT findings of sodium dichloroacetate in a patient with MELAS. | 2004-01-27 |
|
| [Changes in visual event-related potentials and SPECT in dissociative amnesia]. | 2004-01 |
|
| [Development of quantification analysis software for measuring regional cerebral blood flow by the modified split-dose method with (123)I-IMP before and after acetazolamide loading]. | 2003-12 |
|
| [Normalization of cerebral hemodynamics and metabolism after carotid stenting in patients unfit for major surgery]. | 2003-12 |
|
| The clinical role of N-isopropyl-p-[123I]-iodoamphetamine single photon emission computed tomography in the follow-up of choroidal melanoma after radiotherapy. | 2003-04-24 |
Patents
Sample Use Guides
The recommended intravenous dose for SPECTAMINE (lofetamine HCI I-123 Injection) in the average adult patient (70 kg) is 111 to 222 megabecquerels (3 to 6 millicuries).
Route of Administration:
Intravenous
Cerebral tissue was taken from six-day-old Wistar rat pups. Twenty-four explants were cut from the occipital cortex of a single animal and grown in pairs on polyamide carrier grids distributed over 12 petri. The cultures were incubated with iofetamine (5 uCi) and the drug uptake was tested.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:36:05 GMT 2025
by
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on
Mon Mar 31 17:36:05 GMT 2025
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| Record UNII |
877DO43251
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| Record Status |
Validated (UNII)
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| Record Version |
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877DO43251
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DTXSID3045774
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55305
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82691-32-5
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CHEMBL1201308
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PARENT -> SALT/SOLVATE |
