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Description

Tetraglycine hydroperiodide is an iodine-containing chemical, used for water purification. Tetraglycine hydroperiodide is marketed in tablets; each tablet effectively disinfects 1 liter of clear water or 0.5 liter of tainted water by releasing approximately 8 mg free iodine. It requires approximately 30 minutes to inactivate target microorganisms and make water bacteriologically suitable for drinking. To remove iodine taste, a vitamin C pill is added to the kit.

Approval Year

1921
1467
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Surgicide

Approved Use

Surgicide is a broad spectrum topical antiseptic for use on skin and mucous membranes. Use solution without dilution as needed
PubMed

PubMed

TitleDatePubMed
The susceptibility of the fetus and child to chemical pollutants. Special susceptibility of the host to chemical agents: endocrinologic considerations.
1974 May
[Necrotizing hepatitis with a fatal outcome after carbimazole therapy].
1993 Oct 22
Subfulminant hepatitis requiring liver transplantation after benzarone administration.
1994 Jun
Thyroid adaptation to chronic tetraglycine hydroperiodide water purification tablet use.
1995 Jan
Case report: reversible mitral regurgitation and congestive heart failure complicating thyrotoxicosis.
1996 Mar
Propylthiouracil-induced rapidly progressive glomerulonephritis associated with antineutrophil cytoplasmic autoantibodies.
1997 Jul
Adverse reactions to nonionic iodine in contrast-enhanced computed tomography: usefulness of monitoring vital signs.
1998 Jul
Thyrotropin-secreting pituitary adenoma responsive to bromocriptine therapy.
1999 Sep-Oct
Anti-goitrous effect of lecithin-bound iodine in propylthiouracil treated rats.
2000 Jun
Effects of iodine on inducible nitric oxide synthase and cyclooxygenase-2 expression in sulfur mustard-induced skin.
2001 Feb
Effects of selenium and iodine on the expression of c-fos and c-jun mRNA and their proteins in cultured rat hippocampus neurons.
2002 Jun
Effects of selenium and iodine on c-fos and c-jun mRNA and their protein expressions in cultured rat hippocampus cells.
2002 Winter
Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
2003 Apr
Functional expression of sodium iodide symporter (NIS) in human breast cancer tissue.
2003 Jan
Thiocyanate induces cell necrosis and fibrosis in selenium- and iodine-deficient rat thyroids: a potential experimental model for myxedematous endemic cretinism in central Africa.
2004 Feb
Studies on experimental iodine allergy: 3. Low molecular weight elicitogenic antigens of iodine allergy.
2004 May
[Effect of high-iodine intake on MBP mRNA expression in cerebrum of filial mice and selenium intervention].
2005 Jul
Inhibition of N-methyl-N-nitrosourea-induced mammary carcinogenesis by molecular iodine (I2) but not by iodide (I-) treatment Evidence that I2 prevents cancer promotion.
2005 May 31
Involvement of tumor necrosis factor-alpha in sulfur mustard-induced skin lesion; effect of topical iodine.
2005 Nov
Reverse transcriptase inhibitors down-regulate cell proliferation in vitro and in vivo and restore thyrotropin signaling and iodine uptake in human thyroid anaplastic carcinoma.
2005 Oct
Effect of selenium supplementation on activity and mRNA expression of type 1 deiodinase in mice with excessive iodine intake.
2006 Aug
Synergistic regulation of endothelial tight junctions by antioxidant (Se) and polyunsaturated lipid (GLA) via Claudin-5 modulation.
2006 Aug 1
Salt dual-fortified with iodine and micronized ground ferric pyrophosphate affects iron status but not hemoglobin in children in Cote d'Ivoire.
2006 Jul
Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway.
2006 Jul 14
The loss of the chloride channel, ClC-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland.
2006 Mar
Antiseptics, iodine, povidone iodine and traumatic wound cleansing.
2006 Nov
Comparative cytotoxicity of high-osmolar and low-osmolar contrast media on HKCs in vitro.
2006 Nov-Dec
The treatment of Graves' disease in children.
2006 Sep
Sodium iodide symporter is expressed at the preneoplastic stages of liver carcinogenesis and in human cholangiocarcinoma.
2007 Apr
Goiter and other iodine deficiency disorders: A systematic review of epidemiological studies to deconstruct the complex web.
2007 Jan
[Effects of iodine excess and selenium supplement on the levels of thyroid hormone and its receptor expression in filial cerebrum of mice].
2007 Mar
Enhanced expression of adenovirus-mediated sodium iodide symporter gene in MCF-7 breast cancer cells with retinoic acid treatment.
2007 Mar
Increased iodine uptake in thyroid carcinoma after treatment with sodium butyrate and decitabine (5-Aza-dC).
2007 Nov
Comparison of the usefulness of gadodiamide and iodine mixture versus iodinated contrast alone for prevention of contrast-induced nephropathy in patients with chronic kidney disease undergoing coronary angiography.
2007 Oct 1
[Suggestions for prevention of adverse reactions after intravasal administration of iodinated contrast media].
2008
[The effects of iodine/selenium on the function of antigen presentation of peritoneal macrophages in rats].
2008 Jul
Gadolinium and kidney disease: are your patients at risk?
2008 Mar-Apr
Use of gadolinium for carotid artery angiography and stenting in patients with renal insufficiency.
2009 Dec
A blinded, randomized, palatability study comparing variations of 2 popular field water disinfection tablets.
2011 Dec
I-131 dose response for incident thyroid cancers in Ukraine related to the Chornobyl accident.
2011 Jul
The effects of ammonium perchlorate on thyroid homeostasis and thyroid-specific gene expression in rat.
2012 Aug
Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice.
2012 Sep 1
Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry.
2013 Jan
Developmental iodine deficiency delays the maturation of newborn granule neurons associated with downregulation of p35 in postnatal rat hippocampus.
2014 Aug
Patents

Patents

20030153532
9
Name Type Language
POVIDONE-IODINE
HSDB   MART.   MI   ORANGE BOOK   USP   VANDF   WHO-DD  
Common Name English
BETADINE
Brand Name English
2-PYRROLIDINONE, 1-ETHENYL-, HOMOPOLYMER, COMPD. WITH IODINE
Common Name English
POVIDONE-IODINE [MART.]
Common Name English
E-Z PREP 220
Brand Name English
POVIDONE IODINE [VANDF]
Common Name English
E-Z PREP
Brand Name English
PVP-IODINE [INCI]
Common Name English
Povidone-iodine [WHO-DD]
Common Name English
E-Z SCRUB 201
Brand Name English
POVIDONE-IODINE [VANDF]
Common Name English
POVIDONE-IODINE [HSDB]
Common Name English
POVIDONE-IODINE [ORANGE BOOK]
Common Name English
PVP-IODINE
INCI  
INCI  
Official Name English
E-Z SCRUB 241
Brand Name English
1-Vinyl-2-pyrrolidinone polymer, compound with iodine
Common Name English
POVIDONE-IODINE [JAN]
Common Name English
NSC-26245
Code English
POVIDONE-IODINE [MI]
Common Name English
POVIDONE IODINE
VANDF  
Common Name English
POVIDONE-IODINE [USP MONOGRAPH]
Common Name English
Classification Tree Code System Code
WHO-VATC QG51AD01
Created by admin on Fri Dec 15 16:00:47 GMT 2023 , Edited by admin on Fri Dec 15 16:00:47 GMT 2023
WHO-VATC QD08AG02
Created by admin on Fri Dec 15 16:00:47 GMT 2023 , Edited by admin on Fri Dec 15 16:00:47 GMT 2023
NDF-RT N0000007196
Created by admin on Fri Dec 15 16:00:47 GMT 2023 , Edited by admin on Fri Dec 15 16:00:47 GMT 2023
WHO-ATC G01AX11
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
WHO-VATC QD11AC06
Created by admin on Fri Dec 15 16:00:47 GMT 2023 , Edited by admin on Fri Dec 15 16:00:47 GMT 2023
WHO-ATC S01AX18
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
FDA ORPHAN DRUG 564916
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
WHO-ATC R02AA15
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
FDA ORPHAN DRUG 566216
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
WHO-ATC D11AC06
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
NDF-RT N0000175486
Created by admin on Fri Dec 15 16:00:47 GMT 2023 , Edited by admin on Fri Dec 15 16:00:47 GMT 2023
WHO-ATC D08AG02
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
NCI_THESAURUS C254
Created by admin on Fri Dec 15 16:00:47 GMT 2023 , Edited by admin on Fri Dec 15 16:00:47 GMT 2023
WHO-VATC QS01AX18
Created by admin on Fri Dec 15 16:00:47 GMT 2023 , Edited by admin on Fri Dec 15 16:00:47 GMT 2023
CFR 21 CFR 333.210
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
FDA ORPHAN DRUG 647518
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
WHO-VATC QG01AX11
Created by admin on Fri Dec 15 16:00:47 GMT 2023 , Edited by admin on Fri Dec 15 16:00:47 GMT 2023
WHO-VATC QD09AA09
Created by admin on Fri Dec 15 16:00:47 GMT 2023 , Edited by admin on Fri Dec 15 16:00:47 GMT 2023
WHO-ATC D09AA09
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
EPA PESTICIDE CODE 46914
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
WHO-VATC QR02AA15
Created by admin on Fri Dec 15 16:00:47 GMT 2023 , Edited by admin on Fri Dec 15 16:00:47 GMT 2023
Code System Code Type Description
DAILYMED
85H0HZU99M
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
PRIMARY
NSC
26245
Created by admin on Fri Dec 15 16:00:47 GMT 2023 , Edited by admin on Fri Dec 15 16:00:47 GMT 2023
PRIMARY
EPA CompTox
DTXSID8035712
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
PRIMARY
ChEMBL
CHEMBL1201724
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
PRIMARY
WIKIPEDIA
POVIDONE-IODINE
Created by admin on Fri Dec 15 16:00:47 GMT 2023 , Edited by admin on Fri Dec 15 16:00:47 GMT 2023
PRIMARY
LACTMED
Povidone-Iodine
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
PRIMARY
DRUG CENTRAL
4249
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
PRIMARY
MERCK INDEX
m9085
Created by admin on Fri Dec 15 16:00:47 GMT 2023 , Edited by admin on Fri Dec 15 16:00:47 GMT 2023
PRIMARY Merck Index
DRUG BANK
DB06812
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
PRIMARY
NCI_THESAURUS
C766
Created by admin on Fri Dec 15 16:00:47 GMT 2023 , Edited by admin on Fri Dec 15 16:00:47 GMT 2023
PRIMARY
HSDB
6831
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
PRIMARY
MESH
D011206
Created by admin on Fri Dec 15 16:00:47 GMT 2023 , Edited by admin on Fri Dec 15 16:00:47 GMT 2023
PRIMARY
RXCUI
8611
Created by admin on Fri Dec 15 16:00:47 GMT 2023 , Edited by admin on Fri Dec 15 16:00:47 GMT 2023
PRIMARY RxNorm
FDA UNII
85H0HZU99M
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
PRIMARY
EVMPD
SUB14999MIG
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
PRIMARY
CAS
25655-41-8
Created by admin on Fri Dec 15 16:00:46 GMT 2023 , Edited by admin on Fri Dec 15 16:00:46 GMT 2023
PRIMARY
All of the following components must be present:
POVIDONE, UNSPECIFIED
Structure of Iodine
ACTIVE MOIETY
Structure of Iodine
SUBSTANCE RECORD
POVIDONE-IODINE
Definition References
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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