U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula I2
Molecular Weight 253.8089
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Iodine

SMILES

II

InChI

InChIKey=PNDPGZBMCMUPRI-UHFFFAOYSA-N
InChI=1S/I2/c1-2

HIDE SMILES / InChI

Molecular Formula I2
Molecular Weight 253.8089
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Tetraglycine hydroperiodide is an iodine-containing chemical, used for water purification. Tetraglycine hydroperiodide is marketed in tablets; each tablet effectively disinfects 1 liter of clear water or 0.5 liter of tainted water by releasing approximately 8 mg free iodine. It requires approximately 30 minutes to inactivate target microorganisms and make water bacteriologically suitable for drinking. To remove iodine taste, a vitamin C pill is added to the kit.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Surgicide

Approved Use

Surgicide is a broad spectrum topical antiseptic for use on skin and mucous membranes. Use solution without dilution as needed
PubMed

PubMed

TitleDatePubMed
The susceptibility of the fetus and child to chemical pollutants. Special susceptibility of the host to chemical agents: endocrinologic considerations.
1974 May
[Necrotizing hepatitis with a fatal outcome after carbimazole therapy].
1993 Oct 22
Subfulminant hepatitis requiring liver transplantation after benzarone administration.
1994 Jun
Thyroid adaptation to chronic tetraglycine hydroperiodide water purification tablet use.
1995 Jan
Case report: reversible mitral regurgitation and congestive heart failure complicating thyrotoxicosis.
1996 Mar
Propylthiouracil-induced rapidly progressive glomerulonephritis associated with antineutrophil cytoplasmic autoantibodies.
1997 Jul
Adverse reactions to nonionic iodine in contrast-enhanced computed tomography: usefulness of monitoring vital signs.
1998 Jul
Thyrotropin-secreting pituitary adenoma responsive to bromocriptine therapy.
1999 Sep-Oct
Anti-goitrous effect of lecithin-bound iodine in propylthiouracil treated rats.
2000 Jun
Effects of iodine on inducible nitric oxide synthase and cyclooxygenase-2 expression in sulfur mustard-induced skin.
2001 Feb
Effects of selenium and iodine on the expression of c-fos and c-jun mRNA and their proteins in cultured rat hippocampus neurons.
2002 Jun
Effects of selenium and iodine on c-fos and c-jun mRNA and their protein expressions in cultured rat hippocampus cells.
2002 Winter
Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
2003 Apr
Functional expression of sodium iodide symporter (NIS) in human breast cancer tissue.
2003 Jan
Thiocyanate induces cell necrosis and fibrosis in selenium- and iodine-deficient rat thyroids: a potential experimental model for myxedematous endemic cretinism in central Africa.
2004 Feb
Studies on experimental iodine allergy: 3. Low molecular weight elicitogenic antigens of iodine allergy.
2004 May
[Effect of high-iodine intake on MBP mRNA expression in cerebrum of filial mice and selenium intervention].
2005 Jul
Inhibition of N-methyl-N-nitrosourea-induced mammary carcinogenesis by molecular iodine (I2) but not by iodide (I-) treatment Evidence that I2 prevents cancer promotion.
2005 May 31
Involvement of tumor necrosis factor-alpha in sulfur mustard-induced skin lesion; effect of topical iodine.
2005 Nov
Reverse transcriptase inhibitors down-regulate cell proliferation in vitro and in vivo and restore thyrotropin signaling and iodine uptake in human thyroid anaplastic carcinoma.
2005 Oct
Effect of selenium supplementation on activity and mRNA expression of type 1 deiodinase in mice with excessive iodine intake.
2006 Aug
Synergistic regulation of endothelial tight junctions by antioxidant (Se) and polyunsaturated lipid (GLA) via Claudin-5 modulation.
2006 Aug 1
Salt dual-fortified with iodine and micronized ground ferric pyrophosphate affects iron status but not hemoglobin in children in Cote d'Ivoire.
2006 Jul
Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway.
2006 Jul 14
The loss of the chloride channel, ClC-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland.
2006 Mar
Comparative cytotoxicity of high-osmolar and low-osmolar contrast media on HKCs in vitro.
2006 Nov-Dec
The treatment of Graves' disease in children.
2006 Sep
Sodium iodide symporter is expressed at the preneoplastic stages of liver carcinogenesis and in human cholangiocarcinoma.
2007 Apr
Goiter and other iodine deficiency disorders: A systematic review of epidemiological studies to deconstruct the complex web.
2007 Jan
[Effects of iodine excess and selenium supplement on the levels of thyroid hormone and its receptor expression in filial cerebrum of mice].
2007 Mar
Enhanced expression of adenovirus-mediated sodium iodide symporter gene in MCF-7 breast cancer cells with retinoic acid treatment.
2007 Mar
Increased iodine uptake in thyroid carcinoma after treatment with sodium butyrate and decitabine (5-Aza-dC).
2007 Nov
Comparison of the usefulness of gadodiamide and iodine mixture versus iodinated contrast alone for prevention of contrast-induced nephropathy in patients with chronic kidney disease undergoing coronary angiography.
2007 Oct 1
[Suggestions for prevention of adverse reactions after intravasal administration of iodinated contrast media].
2008
[The effects of iodine/selenium on the function of antigen presentation of peritoneal macrophages in rats].
2008 Jul
Gadolinium and kidney disease: are your patients at risk?
2008 Mar-Apr
Use of gadolinium for carotid artery angiography and stenting in patients with renal insufficiency.
2009 Dec
A blinded, randomized, palatability study comparing variations of 2 popular field water disinfection tablets.
2011 Dec
I-131 dose response for incident thyroid cancers in Ukraine related to the Chornobyl accident.
2011 Jul
The effects of ammonium perchlorate on thyroid homeostasis and thyroid-specific gene expression in rat.
2012 Aug
Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice.
2012 Sep 1
Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry.
2013 Jan
Developmental iodine deficiency delays the maturation of newborn granule neurons associated with downregulation of p35 in postnatal rat hippocampus.
2014 Aug
Patents

Patents

Substance Class Chemical
Created
by admin
on Fri Dec 15 15:32:49 GMT 2023
Edited
by admin
on Fri Dec 15 15:32:49 GMT 2023
Record UNII
9679TC07X4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Iodine
EP   HSDB   II   MART.   MI   USP   VANDF   WHO-DD   WHO-IP  
Systematic Name English
IODINE [USP MONOGRAPH]
Common Name English
IODINE [HSDB]
Common Name English
NSC-42355
Code English
IODIUM
HPUS  
Common Name English
IODIUM [HPUS]
Common Name English
IODINE STRONG [VANDF]
Common Name English
IODINE [EP IMPURITY]
Common Name English
IODINE [WHO-IP]
Common Name English
JODOSAN
Common Name English
IODINE [MI]
Common Name English
Iodine [WHO-DD]
Common Name English
IODINE [EP MONOGRAPH]
Common Name English
IODINE [II]
Common Name English
IODINE [VANDF]
Common Name English
IODINE [JAN]
Common Name English
TEGODYNE
Common Name English
IODINE MILD [VANDF]
Common Name English
IODINE [MART.]
Common Name English
IODINE STRONG
VANDF  
Common Name English
IODUM [WHO-IP LATIN]
Common Name English
Classification Tree Code System Code
LOINC 25448-2
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
LOINC 50868-9
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
LOINC 34321-0
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
WHO-VATC QD08AG03
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
LOINC 34320-2
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
LOINC 76657-6
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
LOINC 55928-6
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
LOINC 53872-8
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
LOINC 25936-6
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
LOINC 25449-0
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
NCI_THESAURUS C896
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
WHO-ATC D08AG03
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
WHO-VATC QD08AG53
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
EPA PESTICIDE CODE 46905
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
LOINC 2494-3
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
LOINC 44323-4
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
LOINC 26842-5
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
LOINC 2492-7
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
DSLD 184 (Number of products:5290)
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
DEA NO. 6699
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
WHO-ESSENTIAL MEDICINES LIST 27
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
LOINC 2495-0
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
Code System Code Type Description
CHEBI
17606
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
MESH
D007455
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
NCI_THESAURUS
C594
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
HSDB
34
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
CAS
7553-56-2
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
WIKIPEDIA
Tincture of iodine
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
ECHA (EC/EINECS)
231-442-4
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
MERCK INDEX
m6327
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY Merck Index
DAILYMED
9679TC07X4
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
WIKIPEDIA
Iodine (medical use)
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
PUBCHEM
807
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
FDA UNII
9679TC07X4
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
EVMPD
SUB14239MIG
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
DRUG BANK
DB05382
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
IODINE
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY Description: Heavy, greyish black plates or granules, having a metallic lustre. Solubility: Very slightly soluble in water; soluble in ethanol (~750 g/l) TS; freely soluble in carbon tetrachloride R, carbon disulfide R, and ether R. Category: External antiseptic. Storage: Iodine should be kept in a tightly closed container, preferably made of glass and provided with a glass stopper. Additional information: Iodine volatilizes slowly at room temperature giving violet, irritant vapours. Definition: Iodine contains not less than 99.5% and not more than 100.5% of I.
NSC
42355
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
RXCUI
5933
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY RxNorm
DRUG CENTRAL
4446
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
LACTMED
Iodine
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
SMS_ID
100000092589
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
EPA CompTox
DTXSID7034672
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
CHEBI
24859
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
ChEMBL
CHEMBL1201225
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
WIKIPEDIA
Iodine
Created by admin on Fri Dec 15 15:32:49 GMT 2023 , Edited by admin on Fri Dec 15 15:32:49 GMT 2023
PRIMARY
Related Record Type Details
LABELED -> NON-LABELED
Related Record Type Details
ACTIVE MOIETY