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Details

Stereochemistry ACHIRAL
Molecular Formula C21H15NO9S2.2Na
Molecular Weight 535.455
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SULISATIN SODIUM

SMILES

[Na+].[Na+].CC1=CC=CC2=C1NC(=O)C2(C3=CC=C(OS([O-])(=O)=O)C=C3)C4=CC=C(OS([O-])(=O)=O)C=C4

InChI

InChIKey=IBJXXCVPQABJRR-UHFFFAOYSA-L
InChI=1S/C21H17NO9S2.2Na/c1-13-3-2-4-18-19(13)22-20(23)21(18,14-5-9-16(10-6-14)30-32(24,25)26)15-7-11-17(12-8-15)31-33(27,28)29;;/h2-12H,1H3,(H,22,23)(H,24,25,26)(H,27,28,29);;/q;2*+1/p-2

HIDE SMILES / InChI
Sulisatin (also known as DAN-603) is an indolinone derivative patented by Andreu, Dr., S. A. as a laxative. In preclinical models, Sulisatin increases selectively the colon motility without modifying the speed of gastric, intestinal (small intestine) and caecal emptying in rats. Sulisatin is unable to inhibit water absorption in rat colon while small amounts of Sulisatin may inhibit it significantly.

Approval Year

PubMed

PubMed

TitleDatePubMed
Study of the laxative properties of the disodium salt of the sulfuric diester of 3,3-bis-(4-hydroxyphenyl)-7-methyl-2-indolinone (DAN-603 in the rat.
1976 Mar
Patents

Patents

Sample Use Guides

In Vivo Use Guide
rat 1.5, 3 and 6 mg
Route of Administration: Oral
Name Type Language
SULISATIN SODIUM
WHO-DD  
Common Name English
DAN 603
Code English
Sulisatin sodium [WHO-DD]
Common Name English
LAXITEX
Brand Name English
2H-INDOL-2-ONE, 1,3-DIHYDRO-7-METHYL-3,3-BIS(4-(SULFOOXY)PHENYL)-, SODIUM SALT (1:2)
Common Name English
SODIUM SULISATIN
Common Name English
DAN-603
Code English
SULISATIN DISODIUM SALT [MI]
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID40203452
Created by admin on Fri Dec 15 18:44:25 GMT 2023 , Edited by admin on Fri Dec 15 18:44:25 GMT 2023
PRIMARY
CAS
54935-04-5
Created by admin on Fri Dec 15 18:44:25 GMT 2023 , Edited by admin on Fri Dec 15 18:44:25 GMT 2023
PRIMARY
MERCK INDEX
m947
Created by admin on Fri Dec 15 18:44:25 GMT 2023 , Edited by admin on Fri Dec 15 18:44:25 GMT 2023
PRIMARY Merck Index
FDA UNII
7S636L78GU
Created by admin on Fri Dec 15 18:44:25 GMT 2023 , Edited by admin on Fri Dec 15 18:44:25 GMT 2023
PRIMARY
EVMPD
SUB04641MIG
Created by admin on Fri Dec 15 18:44:25 GMT 2023 , Edited by admin on Fri Dec 15 18:44:25 GMT 2023
PRIMARY
PUBCHEM
41237
Created by admin on Fri Dec 15 18:44:25 GMT 2023 , Edited by admin on Fri Dec 15 18:44:25 GMT 2023
PRIMARY
SMS_ID
100000085052
Created by admin on Fri Dec 15 18:44:25 GMT 2023 , Edited by admin on Fri Dec 15 18:44:25 GMT 2023
PRIMARY