PHENINDAMINE

US Approved OTC

First approved in 1947

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H19N
Molecular Weight	261.3609
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCC2=C(C1)C(C3=CC=CC=C23)C4=CC=CC=C4

InChI

InChIKey=ISFHAYSTHMVOJR-UHFFFAOYSA-N

InChI=1S/C19H19N/c1-20-12-11-16-15-9-5-6-10-17(15)19(18(16)13-20)14-7-3-2-4-8-14/h2-10,19H,11-13H2,1H3

HIDE SMILES / InChI

Description
Sources: https://www.drugs.com/mtm/phenindamine.html
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/18907211

Phenindamine (thephorin or 2-methyl-9-phenyl-2,3,4,9-tetrahydro-1-pyridindene) a pyridindene derivative proved to be a potent antihistaminic. Phenindamine was used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H1 receptor 315 Target ID: CHEMBL231 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7650688 \| https://www.ncbi.nlm.nih.gov/pubmed/18907211	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Allergy 44 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18878636 https://www.ncbi.nlm.nih.gov/pubmed/18867853 https://www.ncbi.nlm.nih.gov/pubmed/18879474	Primary		Approved 8429	THEPHORIN Approved Use Phenindamine was used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold. Launch Date -7.1634243E11

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY573096	https://www.001chemical.com/chem/82-88-2
ABI Chem	AC1L1X1J
AN PharmaTech	AN-28759
Ambinter	Amb17619242	http://www.ambinter.com/reference/17619242
BOC Sciences	1316183
BOC Sciences	569-59-5
BOC Sciences	82-88-2
ChemMol	49419261	http://www.chemmol.com/chemmol/49419261.html
ChemMol	99160490	http://www.chemmol.com/chemmol/99160490.html
Compound Cloud	11290
Compound Cloud	11291
Hangzhou Yuhao Chemical Technology	RT9838
HongKong Chemhere	SCE32562
Molcore	MC573096	https://www.molcore.com/product/82-88-2
MuseChem	R050409
MuseChem	R068189
NCI Plated 2007	91526
NovoSeek	11291
Sigma Aldrich	PH011869
Sigma Aldrich	PH011869\|ALDRICH
THE BioTek	bt-363837	https://www.thebiotek.com/product/others/bt-363837
Toronto Research Chemicals	F594065
Toronto Research Chemicals	H600523
Toronto Research Chemicals	P297000
Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd.	PH-1224
ZINC	ZINC000000968338	http://zinc15.docking.org/substances/ZINC000000968338
ZINC	ZINC000000968340	http://zinc15.docking.org/substances/ZINC000000968340
eMolecules	110009458
eMolecules	36759216
eMolecules	48669401

PubMed

Title	Date	PubMed
Treatment of allergic and some other dermatoses with thephorin; a preliminary report.	1947 Aug	20266661
Thephorin in the treatment of disseminated neurodermatitis.	1948 Aug	18877034
The effects of phenindamine tartrate on sleepiness and psychomotor performance.	1992 Dec	1360991
The histamine H1-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H1-antagonists and including a known interaction site on the receptor.	1995 Aug 18	7650688

Patents

Sample Use Guides

In Vivo Use Guide

The maximum amount of phenindamine that you should take in 1 day is 75 mg.

Route of Administration: Other

In Vitro Use Guide

Unknown

Name

Type

Language

PHENINDAMINE

Official Name

English

2-METHYL-9-PHENYL-2,3,4,9-TETRAHYDRO-1-PYRIDINDENE

Common Name

English

PHENINDAMINE [MI]

Common Name

English

2,3,4,9-TETRAHYDRO-2-METHYL-9-PHENYL-1H-INDENO(2,1-C)PYRIDINE

Systematic Name

English

PHENINDAMINE [VANDF]

Common Name

English

phenindamine [INN]

Common Name

English

1,2,3,4-TETRAHYDRO-2-METHYL-9-PHENYL-2-AZAFLUORENE

Systematic Name

English

NU-1504

Code

English

THEPHORIN

Brand Name

English

Phenindamine [WHO-DD]

Common Name

English

1H-INDENO(2,1-C)PYRIDINE, 2,3,4,9-TETRAHYDRO-2-METHYL-9-PHENYL-

Systematic Name

English

Classification Tree Code System Code

WHO-VATC

QR06AX04