PHENINDAMINE

US Approved OTC

First approved in 1947

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H19N
Molecular Weight	261.3609
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCC2=C(C1)C(C3=CC=CC=C23)C4=CC=CC=C4

InChI

InChIKey=ISFHAYSTHMVOJR-UHFFFAOYSA-N

InChI=1S/C19H19N/c1-20-12-11-16-15-9-5-6-10-17(15)19(18(16)13-20)14-7-3-2-4-8-14/h2-10,19H,11-13H2,1H3

HIDE SMILES / InChI

Description
Sources: https://www.drugs.com/mtm/phenindamine.html
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/18907211

Phenindamine (thephorin or 2-methyl-9-phenyl-2,3,4,9-tetrahydro-1-pyridindene) a pyridindene derivative proved to be a potent antihistaminic. Phenindamine was used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H1 receptor 315 Target ID: CHEMBL231 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7650688 \| https://www.ncbi.nlm.nih.gov/pubmed/18907211	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Allergy 44 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18878636 https://www.ncbi.nlm.nih.gov/pubmed/18867853 https://www.ncbi.nlm.nih.gov/pubmed/18879474	Primary		Approved 8429	THEPHORIN Approved Use Phenindamine was used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold. Launch Date 1947

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY573096	https://www.001chemical.com/chem/82-88-2
ABI Chem	AC1L1X1J
AN PharmaTech	AN-28759
Ambinter	Amb17619242	http://www.ambinter.com/reference/17619242
BOC Sciences	1316183
BOC Sciences	569-59-5
BOC Sciences	82-88-2
ChemMol	49419261	http://www.chemmol.com/chemmol/49419261.html
ChemMol	99160490	http://www.chemmol.com/chemmol/99160490.html
Compound Cloud	11290
Compound Cloud	11291
Hangzhou Yuhao Chemical Technology	RT9838
HongKong Chemhere	SCE32562
Molcore	MC573096	https://www.molcore.com/product/82-88-2
MuseChem	R050409
MuseChem	R068189
NCI Plated 2007	91526
NovoSeek	11291
Sigma Aldrich	PH011869
Sigma Aldrich	PH011869\|ALDRICH
THE BioTek	bt-363837	https://www.thebiotek.com/product/others/bt-363837
Toronto Research Chemicals	F594065
Toronto Research Chemicals	H600523
Toronto Research Chemicals	P297000
Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd.	PH-1224
ZINC	ZINC000000968338	http://zinc15.docking.org/substances/ZINC000000968338
ZINC	ZINC000000968340	http://zinc15.docking.org/substances/ZINC000000968340
eMolecules	110009458
eMolecules	36759216
eMolecules	48669401

PubMed

Title	Date	PubMed
Treatment of allergic and some other dermatoses with thephorin; a preliminary report.	1947 Aug	20266661
Histamine and the antihistaminic drugs.	1950 May	15414437
The effects of phenindamine tartrate on sleepiness and psychomotor performance.	1992 Dec	1360991
The histamine H1-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H1-antagonists and including a known interaction site on the receptor.	1995 Aug 18	7650688

Patents

Sample Use Guides

In Vivo Use Guide

The maximum amount of phenindamine that you should take in 1 day is 75 mg.

Route of Administration: Other

In Vitro Use Guide

Unknown

Name

Type

Language

PHENINDAMINE

Official Name

English

2-METHYL-9-PHENYL-2,3,4,9-TETRAHYDRO-1-PYRIDINDENE

Common Name

English

PHENINDAMINE [MI]

Common Name

English

2,3,4,9-TETRAHYDRO-2-METHYL-9-PHENYL-1H-INDENO(2,1-C)PYRIDINE

Systematic Name

English

PHENINDAMINE [VANDF]

Common Name

English

phenindamine [INN]

Common Name

English

1,2,3,4-TETRAHYDRO-2-METHYL-9-PHENYL-2-AZAFLUORENE

Systematic Name

English

NU-1504

Code

English

THEPHORIN

Brand Name

English

Phenindamine [WHO-DD]

Common Name

English

1H-INDENO(2,1-C)PYRIDINE, 2,3,4,9-TETRAHYDRO-2-METHYL-9-PHENYL-

Systematic Name

English

Classification Tree Code System Code

WHO-VATC

QR06AX04