COBALTOUS ACETATE TETRAHYDRATE

US Approved Allergenic Extract (1994)

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	2C2H3O2.Co.4H2O
Molecular Weight	249.0824
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of COBALTOUS ACETATE TETRAHYDRATE

Structure Search

SMILES

O.O.O.O.[Co++].CC([O-])=O.CC([O-])=O

InChI

InChIKey=ZBYYWKJVSFHYJL-UHFFFAOYSA-L

InChI=1S/2C2H4O2.Co.4H2O/c2*1-2(3)4;;;;;/h2*1H3,(H,3,4);;4*1H2/q;;+2;;;;/p-2

HIDE SMILES / InChI

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/104729ISBN 9780873715980, Foden C.R., Weddell J.L., 'Hazardous Materials: Emergency Action Data' (1991), Retrieved from https://books.google.com/books?id=4IPE8Pjhm8UC&pgISBN: 978-94-010-7024-9, Matar M.S., Mirbach M.J.,Tayim H.A. 'Catalysis in Petrochemical Processes' (1988), p.136, Retrieved from https://books.google.com/books?id=MkD2JnDkZYYC&dqhttp://aygrt.isrj.org/colorArticles/4972.pdfhttp://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744048e0023/pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27527840https://fscimage.fishersci.com/msds/05330.htmhttp://laboratorychemicals.in/uploads/msds/10026-17-2-49128.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2253206https://monographs.iarc.fr/ENG/Monographs/vol52/mono52-16.pdfhttp://datasheets.scbt.com/sc-227251.pdf
Curator's Comment: description was created based on several sources, including: DOI:10.1080/00958970802416020 | DOI:10.1080/00958972.2010.521553 | https://www.ncbi.nlm.nih.gov/pubmed/7201957 | https://www.ncbi.nlm.nih.gov/pubmed/18475879

Cobaltous iodide is a catalyst used in organic synthesis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Hypoxia-inducible factor 1-alpha inhibitor 22 Target ID: Q9NWT6 Gene ID: 55662.0 Gene Symbol: HIF1AN Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/15941769	Inhibitor 8297		1.0 µM [Ki]

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Anemia 68 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18120180 https://www.ncbi.nlm.nih.gov/pubmed/940922	Primary	Withdrawn	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Cobalt iontophoresis techniques for tracing afferent and efferent connections in the vertebrate CNS.	1975 May 2	1097054
Cobalt and antimony: genotoxicity and carcinogenicity.	2003 Dec 10	14643417
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway.	2005 Aug	15941769
Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals.	2009 Apr	19338585
Differential pulmonary effects of CoO and La2O3 metal oxide nanoparticle responses during aerosolized inhalation in mice.	2016 Aug 15	27527840

Patents

Sample Use Guides

In Vivo Use Guide

For treatment of anemia, oral cobal chloride was administered at doses 25 mg and 50 mg daily.

Route of Administration: Oral

In Vitro Use Guide

HIF asparaginyl hydroxylase activity was measured by a method based on the hydroxylation coupled decarboxylation of 2-oxoglutarate with the synthetic HIF-1α peptides in the presence of varying concentrations of Co (1-5 uM). Ki for HIF asparaginyl hydroxylase was 1uM.

Name

Type

Language

COBALTOUS ACETATE TETRAHYDRATE

Common Name

English

COBALTOUS ACETATE TETRAHYDRATE [MI]

Common Name

English

COBALT ACETATE TETRAHYDRATE

Systematic Name

English

BIS(ACETATO)TETRAAQUOCOBALT

Common Name

English

COBALT DIACETATE TETRAHYDRATE

Systematic Name

English

COBALT(II) ACETATE TETRAHYDRATE

Systematic Name

English

Code System Code Type Description

PUBCHEM

61372