U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2C2H3O2.Co.4H2O
Molecular Weight 249.0824
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of COBALTOUS ACETATE TETRAHYDRATE

SMILES

O.O.O.O.[Co++].CC([O-])=O.CC([O-])=O

InChI

InChIKey=ZBYYWKJVSFHYJL-UHFFFAOYSA-L
InChI=1S/2C2H4O2.Co.4H2O/c2*1-2(3)4;;;;;/h2*1H3,(H,3,4);;4*1H2/q;;+2;;;;/p-2

HIDE SMILES / InChI
Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Q9NWT6
Gene ID: 55662.0
Gene Symbol: HIF1AN
Target Organism: Homo sapiens (Human)
1.0 µM [Ki]
Conditions
PubMed

PubMed

TitleDatePubMed
Erythropoietic effect of cobalt in patients with or without anemia.
1949 May 12
Cobalt iontophoresis techniques for tracing afferent and efferent connections in the vertebrate CNS.
1975 May 2
Improved methods for cobalt filling and silver intensification of insect motor neurons.
1982 Jul
Acute oral toxicity of inorganic cobalt compounds in rats.
1982 Jun
Inhalation toxicity studies of cobalt sulfate in F344/N rats and B6C3F1 mice.
1990 Aug
Carcinogenic sulfide salts of nickel and cadmium induce H2O2 formation by human polymorphonuclear leukocytes.
1990 Dec 1
Synthesis and Anti-Candida Activity of Cobalt(II) Complexes of Benzene-1,2-Dioxyacetic Acid (bdoaH(2)). X-Ray Crystal Structures of [Co(bdoa)(H(2)O)(3)] 3.5H(2)O and {[CO(phen)(3)](bdoa)}(2)24H(2)O (phen = 1,10-Phenanthroline).
1999
Determination of trace metal ions in common salt by stripping voltammetry.
1999 Nov-Dec
Cobalt and antimony: genotoxicity and carcinogenicity.
2003 Dec 10
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway.
2005 Aug
Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals.
2009 Apr
In vitro assessment of cobalt oxide particle toxicity: identifying and circumventing interference.
2013 Sep
Purification and characterization of glucose 6-phosphate dehydrogenase enzyme from rainbow trout (Oncorhynchus mykiss) liver and investigation of the effects of some metal ions on enzyme activity.
2015 May
Differential pulmonary effects of CoO and La2O3 metal oxide nanoparticle responses during aerosolized inhalation in mice.
2016 Aug 15
Patents

Sample Use Guides

In Vivo Use Guide
For treatment of anemia, oral cobal chloride was administered at doses 25 mg and 50 mg daily.
Route of Administration: Oral
HIF asparaginyl hydroxylase activity was measured by a method based on the hydroxylation coupled decarboxylation of 2-oxoglutarate with the synthetic HIF-1α peptides in the presence of varying concentrations of Co (1-5 uM). Ki for HIF asparaginyl hydroxylase was 1uM.
Name Type Language
COBALTOUS ACETATE TETRAHYDRATE
MI  
Common Name English
COBALTOUS ACETATE TETRAHYDRATE [MI]
Common Name English
COBALT ACETATE TETRAHYDRATE
Systematic Name English
BIS(ACETATO)TETRAAQUOCOBALT
Common Name English
COBALT DIACETATE TETRAHYDRATE
Systematic Name English
COBALT(II) ACETATE TETRAHYDRATE
Systematic Name English
Code System Code Type Description
PUBCHEM
61372
Created by admin on Fri Dec 15 17:01:03 GMT 2023 , Edited by admin on Fri Dec 15 17:01:03 GMT 2023
PRIMARY
MERCK INDEX
m3687
Created by admin on Fri Dec 15 17:01:03 GMT 2023 , Edited by admin on Fri Dec 15 17:01:03 GMT 2023
PRIMARY Merck Index
CAS
6147-53-1
Created by admin on Fri Dec 15 17:01:03 GMT 2023 , Edited by admin on Fri Dec 15 17:01:03 GMT 2023
PRIMARY
FDA UNII
7648Z91O1N
Created by admin on Fri Dec 15 17:01:03 GMT 2023 , Edited by admin on Fri Dec 15 17:01:03 GMT 2023
PRIMARY
EPA CompTox
DTXSID80210423
Created by admin on Fri Dec 15 17:01:03 GMT 2023 , Edited by admin on Fri Dec 15 17:01:03 GMT 2023
PRIMARY