DAZEPINIL

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H18N2
Molecular Weight	250.3382
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C(CC2=CC=CC=C2N=C1C)C3=CC=CC=C3

InChI

InChIKey=STDYWHYUOSSCBO-UHFFFAOYSA-N

InChI=1S/C17H18N2/c1-13-18-16-11-7-6-10-15(16)12-17(19(13)2)14-8-4-3-5-9-14/h3-11,17H,12H2,1-2H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7200144

Dazepinil (HRP 543) is a 1,3-benzodiazepine antidepressant, developed by Hoerscht in the early 1980s. In mouse tests, dazepinil inhibited tetrabenazine-induced ptosis and potentiated yohimbine toxicity. In vitro, dazepinil inhibited norepinephrine and serotonin uptake into rat brain synaptosomes and lacked anticholinergic activity.

Originator

Approval Year

PubMed

Title	Date	PubMed

(+/-)-4-Aryl-4,5-dihydro-3H-1,3-benzodiazepines. 2. Nuclear-substituted analogues of (+/-)-4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine and (+/-)-4,5-dihydro-2-ethyl-3-methyl-4-phenyl-3H-1,3-benzodiazepine as potential antidepressant agents.	1982 Apr	7069712

Name

Type

Language

DAZEPINIL

Official Name

English

(±)-4,5-DIHYDRO-2,3-DIMETHYL-4-PHENYL-3H-1,3-BENZODIAZEPINE

Systematic Name

English

dazepinil [INN]

Common Name

English

3H-1,3-BENZODIAZEPINE, 4,5-DIHYDRO-2,3-DIMETHYL-4-PHENYL-, (±)-

Systematic Name

English

P-762543

Code

English

Code System Code Type Description

FDA UNII

730EPY2HSM