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Details

Stereochemistry RACEMIC
Molecular Formula C7H15Cl2N2O2P
Molecular Weight 261.086
Optical Activity ( + / - )
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CYCLOPHOSPHAMIDE ANHYDROUS

SMILES

ClCCN(CCCl)P1(=O)NCCCO1

InChI

InChIKey=CMSMOCZEIVJLDB-UHFFFAOYSA-N
InChI=1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12)

HIDE SMILES / InChI

Description

Cyclophosphamide (the generic name for Cytoxan, Neosar, Revimmune), also known as cytophosphane, is a nitrogen mustard alkylating agent, from the oxazophorines group. It is used to treat various types of cancer and some autoimmune disorders. It is a "prodrug"; it is converted in the liver to active forms that have chemotherapeutic activity

Originator

Approval Year

Sample Use Guides

In Vivo Use Guide
40-50 mg per kg in divided doses over 2 to 5 days in malignant diseases and 2 mg per kg daily for 8 to 12 weeks in minimal change nephrotic sindrome
Route of Administration: Intravenous
In Vitro Use Guide
from 20 to 160 ug/ml
Name Type Language
CYCLOPHOSPHAMIDE ANHYDROUS
Common Name English
NSC-26271
Code English
ANHYDROUS CYCLOPHOSPHAMIDE
Common Name English
(+/-)-2-(BIS(2-CHLOROETHYL)AMINO)TETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE
Systematic Name English
2H-1,3,2-OXAZAPHOSPHORIN-2-AMINE, N,N-BIS(2-CHLOROETHYL)TETRAHYDRO-, 2-OXIDE
Systematic Name English
CYCLOPHOSPHAMIDE [HSDB]
Common Name English
CYCLOPHOSPHAMIDE [WHO-DD]
Common Name English
CYCLOPHOSPHAMIDE LYOPHILIZED
Common Name English
CYCLOPHOSPHAMIDE ANHYDROUS [MI]
Common Name English
CYCLOPHOSPHAMIDE [INN]
Common Name English
CYCLOPHOSPHAMIDE, ANHYDROUS
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C697
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
NDF-RT N0000000236
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
EPA PESTICIDE CODE 624870
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
NDF-RT N0000175558
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
WHO-ATC L01AA01
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
NCI_THESAURUS C574
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
Code System Code Type Description
HSDB
50-18-0
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
PRIMARY
CAS
50-18-0
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
PRIMARY
EVMPD
SUB121739
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
PRIMARY
PUBCHEM
2907
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
PRIMARY
RXCUI
221085
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
ALTERNATIVE
EVMPD
SUB06859MIG
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
PRIMARY
INN
878
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
PRIMARY
DRUG BANK
DB00531
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
PRIMARY
MERCK INDEX
M4013
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
PRIMARY Merck Index
EPA CompTox
50-18-0
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
PRIMARY
ECHA (EC/EINECS)
200-015-4
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
PRIMARY
RXCUI
1545988
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
PRIMARY
NCI_THESAURUS
C61694
Created by admin on Mon Oct 21 22:33:24 UTC 2019 , Edited by admin on Mon Oct 21 22:33:24 UTC 2019
PRIMARY