Details
Stereochemistry | ACHIRAL |
Molecular Formula | C26H29F2N7.2CH4O3S |
Molecular Weight | 669.763 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CS(O)(=O)=O.CS(O)(=O)=O.FC1=CC=C(C=C1)C(N2CCN(CC2)C3=NC(NCC=C)=NC(NCC=C)=N3)C4=CC=C(F)C=C4
InChI
InChIKey=MRDBGMJEPGXQHJ-UHFFFAOYSA-N
InChI=1S/C26H29F2N7.2CH4O3S/c1-3-13-29-24-31-25(30-14-4-2)33-26(32-24)35-17-15-34(16-18-35)23(19-5-9-21(27)10-6-19)20-7-11-22(28)12-8-20;2*1-5(2,3)4/h3-12,23H,1-2,13-18H2,(H2,29,30,31,32,33);2*1H3,(H,2,3,4)
Almitrine, a selective pulmonary vasoconstrictor and a respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. In combination with raubasine, it used under the brand, name Duxil for the treatment of age-related cerebral disorders and functional rehabilitation after stroke. In addition, Duxil has been considered as an alternative treatment for dementia, but because of the low methodological quality of included trials and the small number of trials, the obtained data did not provide sufficient evidence to support the routine use of this drug for the disease.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: P05023|||Q9UJ20 Gene ID: 476.0 Gene Symbol: ATP1A1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/2527061 |
PubMed
Title | Date | PubMed |
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[Competitive study of the effects of naloxone and of almitrine on fentanyl analgesia in the anesthetized dog: effects on the muzzle opening reflex and blood gases]. | 1980 |
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Peripheral neuropathy in patients treated with almitrine dimesylate. | 1985 Jun 1 |
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Physiology in medicine: importance of hypoxic pulmonary vasoconstriction in maintaining arterial oxygenation during acute respiratory failure. | 2001 |
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Effect of inhaled prostacyclin in combination with almitrine on ventilation-perfusion distributions in experimental lung injury. | 2001 Mar |
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Effects of combined high-dose partial liquid ventilation and almitrine on pulmonary gas exchange and hemodynamics in an animal model of acute lung injury. | 2001 Mar |
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[Comparative changes in PaO2 in moderately hypoxemic COPD patients treated with almitrine versus placebo for one year]. | 2001 Sep |
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An investigation into the mechanism of action of almitrine on isolated rat diaphragm muscle fatigue. | 2002 |
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Jian Nao Ning for treatment of memory impairment in patients with mild or moderate multi-infarct dementia. | 2002 Dec |
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Primary alveolar hypoventilation and response to the respiratory stimulant almitrine. | 2002 Dec |
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Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury. | 2002 Dec |
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[Effect of almitrine/raubasine on cerebral metabolism in the elderly]. | 2002 Mar 30 |
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Vascular pharmacology of acute lung injury and acute respiratory distress syndrome. | 2002 Nov |
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[Gas exchange in acute respiratory distress syndrome]. | 2003 |
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Selective pulmonary vasodilation in acute respiratory distress syndrome. | 2003 Apr |
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Long-term effects of almitrine bismesylate in COPD patients with chronic hypoxaemia. | 2003 Jun |
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Orthodeoxia--an uncommon presentation following bilateral thoracic sympathectomy. | 2003 Oct |
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pO2 - Do we treat the right thing? | 2003 Sep-Oct |
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Clinical review: Independent lung ventilation in critical care. | 2005 |
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Medroxyprogesterone improves nocturnal breathing in postmenopausal women with chronic obstructive pulmonary disease. | 2005 Apr 4 |
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Low- vs high-dose almitrine combined with nitric oxide to prevent hypoxia during open-chest one-lung ventilation. | 2005 Sep |
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[The effects of antidepressant treatment on efficacy of antihypertensive therapy in elderly hypertension]. | 2006 Aug |
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An anesthesiologist's guide to hypoxic pulmonary vasoconstriction: implications for managing single-lung anesthesia and atelectasis. | 2006 Feb |
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[Research of kingsbrain on improving the learning and memory ability of MCAO rats]. | 2006 Mar |
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[Effect of prepared Polygonum multiflorum on striatum extracellular acetylcholine and choline in rats of intracerebral perfusion with sodium azide]. | 2006 May |
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[A clinical study on a randomized, double-blind control of Chinese medicine granules in treatment of vascular dementia]. | 2006 Oct |
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[Clinical research of effect of Yishen Yangnao capsule on vascular dementia]. | 2007 Apr |
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Low-tidal-volume ventilation. | 2007 Dec 13 |
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[Observation on therapeutic effect of puncturing with needles in alignment at the hairline region on vascular dementia]. | 2007 Jun |
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Current concepts in the management of hepatopulmonary syndrome. | 2008 |
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Association between inflammatory mediators and response to inhaled nitric oxide in a model of endotoxin-induced lung injury. | 2008 |
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[Combination of thiotropium bromide with almitrine and pulmonary rehabilitation in the treatment of patients with chronic obstructive pulmonary disease]. | 2008 |
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[Clinical investigation on electroacupuncture treatment of vascular dementia with "Xiusanzhen"]. | 2008 Apr |
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Role of nitric oxide in management of acute respiratory distress syndrome. | 2008 Jul |
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Anaesthesia for serial whole-lung lavage in a patient with severe pulmonary alveolar proteinosis: a case report. | 2008 Nov 27 |
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[Effect of long-time retention of scalp needle on the abilities of cognition, daily living activity and P300 in vascular dementia patients]. | 2008 Oct |
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Obesity hypoventilation syndrome. | 2009 Apr |
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Stability-indicating methods for the determination of a mixture of almitrine and raubasine by derivative spectrophotometry. | 2009 Jun |
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Rescue strategies for refractory hypoxemia: a critical appraisal. | 2009 Nov 26 |
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The neuronal guidance protein netrin-1 reduces alveolar inflammation in a porcine model of acute lung injury. | 2010 |
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Almitrine-Raubasine combination for dementia. | 2011 Mar 16 |
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Evaluation of Almitrine Infusion During Veno-Venous Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome in Adults. | 2019 Aug |
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NCI_THESAURUS |
C47795
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m1564
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249-726-1
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53779
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C79962
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ACTIVE MOIETY
SUBSTANCE RECORD