1,4-Sorbitan is a sorbitol anhydration product. 1,4-Sorbitan is a precursor to environmentally benign surfactants. It is a component of Sorbitol-Sorbitan mixtures used as soft gel plasticizers. They enhance the soft gelatin capsule finish gloss for a premium appearance, help to prevent leakage, provide consistent pharmaceutical quality, and extend shelf life by maintaining a proper moisture balance within the capsule shell.
Originator
Approval Year
PubMed
Title | Date | PubMed |
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Final report on the safety assessment of PEG-6, -8, and -20 sorbitan beeswax. | 2001 |
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Investigating the molecular heterogeneity of polysorbate emulsifiers by MALDI-TOF MS. | 2001 Jul |
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Comparison of impact of the different hydrophilic carriers on the properties of piperazine-containing drug. | 2001 May |
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A novel synthesis of D-galactofuranosyl, D-glucofuranosyl and D-mannofuranosyl 1-phosphates based on remote activation of new and free hexofuranosyl donors. | 2002 Dec 16 |
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Rheological properties of three component creams containing sorbitan monoesters as surfactants. | 2002 Oct 24 |
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Formation and characterization of three-component-sorbitan monoester surfactant, oil and water-creams. | 2004 Jan 9 |
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Coupling aggressive mass removal with microbial reductive dechlorination for remediation of DNAPL source zones: a review and assessment. | 2005 Apr |
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General one-step synthesis of free hexofuranosyl 1-phosphates using unprotected 1-thioimidoyl hexofuranosides. | 2005 Feb 4 |
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Cationic niosomes as gene carriers: preparation and cellular uptake in vitro. | 2005 Jun |
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Sorbitan monopalmitate-based proniosomes for transdermal delivery of chlorpheniramine maleate. | 2005 Mar-Apr |
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Niosomes with sorbitan monoester as a carrier for vaginal delivery of insulin: studies in rats. | 2005 Nov-Dec |
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Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products. | 2005 Oct 15 |
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Formulation and evaluation of a vitamin C multiple emulsion. | 2006 |
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Emulsifier content and side effects of oil-based adjuvant vaccine in swine. | 2006 Aug |
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Composition analysis of two batches of polysorbate 60 using MS and NMR techniques. | 2006 Mar 18 |
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Water mass transfer in W/O emulsions. | 2006 May 15 |
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Enzymatic synthesis of sorbitan methacrylate according to acyl donors. | 2006 Spring |
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Optimization of lipase-catalyzed synthesis of sorbitan acrylate using response surface methodology. | 2007 Apr |
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Evidence for vesicle formation from 1:1 nonionic surfactant span 60 and fatty alcohol mixtures in aqueous ethanol: potential delivery vehicle composition. | 2007 Aug 1 |
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Phase transition water-in-oil microemulsions as ocular drug delivery systems: in vitro and in vivo evaluation. | 2007 Jan 2 |
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Correlation between transcript profiles and fitness of deletion mutants in anaerobic chemostat cultures of Saccharomyces cerevisiae. | 2007 Mar |
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The use of solvent relaxation technique to investigate headgroup hydration and protein binding of simple and mixed phosphatidylcholine/surfactant bilayer membranes. | 2007 May |
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Bioremediation of diesel fuel contaminated soil: effect of non ionic surfactants and selected bacteria addition. | 2007 Sep |
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Dermal delivery of selected hydrophilic drugs from elastic liposomes: effect of phospholipid formulation and surfactants. | 2007 Sep |
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Selection of surfactants for enhancing diesel hydrocarbons-contaminated media bioremediation. | 2008 Apr 15 |
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Allergens in corticosteroid vehicles. | 2008 Jan-Feb |
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Effect of water-in-oil microemulsions and lamellar liquid crystalline systems on the precorneal tear film of albino New Zealand rabbits. | 2008 Mar |
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Some considerations about the hydrophilic-lipophilic balance system. | 2008 May 22 |
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Sorbitan sesquioleate, a common emulsifier in topical corticosteroids, is an important contact allergen. | 2008 Nov-Dec |
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Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery. | 2009 Jul 30 |
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Efficacy of niosomal formulation of diallyl sulfide against experimental candidiasis in Swiss albino mice. | 2009 Oct |
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Structure of high internal phase aqueous-in-oil emulsions and related inverse micelle solutions. 3. Variation of surfactant. | 2009 Sep 10 |
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Between the devil and the deep blue sea: dispersants in the gulf of Mexico. | 2010 Aug |
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Comparative study on the effects of some polyoxyethylene alkyl ether and sorbitan fatty acid ester surfactants on the performance of transdermal carvedilol proniosomal gel using experimental design. | 2010 Dec |
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Niosome as a drug carrier for topical delivery of N-acetyl glucosamine. | 2010 Jul |
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Application of liquid chromatography in polymer non-ionic antistatic additives analysis. | 2010 Nov |
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21 CFR 175.320
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12441-09-7
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SORBITAN
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DTXSID00872901
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DB14474
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235-671-0
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C45678
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1367146
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SUB36296
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C75651
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All of the following components must be present:
SUBSTANCE RECORD