SORBITAN

Description
Sources: https://pubs.acs.org/doi/abs/10.1021/ja01210a001 | https://link.springer.com/chapter/10.1007%2F978-981-10-0332-5_5 | https://www.spipharma.com/media/2384/soft-gel-plasticizers-product-sales-bulletin.pdf

1,4-Sorbitan is a sorbitol anhydration product. 1,4-Sorbitan is a precursor to environmentally benign surfactants. It is a component of Sorbitol-Sorbitan mixtures used as soft gel plasticizers. They enhance the soft gelatin capsule finish gloss for a premium appearance, help to prevent leakage, provide consistent pharmaceutical quality, and extend shelf life by maintaining a proper moisture balance within the capsule shell.

Originator

Approval Year

PubMed

Title	Date	PubMed
Comparative study on the effects of some polyoxyethylene alkyl ether and sorbitan fatty acid ester surfactants on the performance of transdermal carvedilol proniosomal gel using experimental design.	2010-12	21063815
Application of liquid chromatography in polymer non-ionic antistatic additives analysis.	2010-11	20931612
Between the devil and the deep blue sea: dispersants in the gulf of Mexico.	2010-08	20675260
Niosome as a drug carrier for topical delivery of N-acetyl glucosamine.	2010-07	21589799
Efficacy of niosomal formulation of diallyl sulfide against experimental candidiasis in Swiss albino mice.	2009-10	19839808
Structure of high internal phase aqueous-in-oil emulsions and related inverse micelle solutions. 3. Variation of surfactant.	2009-09-10	19681586
Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery.	2009-07-30	19394413
Sorbitan sesquioleate, a common emulsifier in topical corticosteroids, is an important contact allergen.	2009-01-13	19134436
Some considerations about the hydrophilic-lipophilic balance system.	2008-05-22	18258397
Selection of surfactants for enhancing diesel hydrocarbons-contaminated media bioremediation.	2008-04-15	17850960
Allergens in corticosteroid vehicles.	2008-03-19	18346395
Effect of water-in-oil microemulsions and lamellar liquid crystalline systems on the precorneal tear film of albino New Zealand rabbits.	2008-03	19668396
Bioremediation of diesel fuel contaminated soil: effect of non ionic surfactants and selected bacteria addition.	2007-09	17970296
Dermal delivery of selected hydrophilic drugs from elastic liposomes: effect of phospholipid formulation and surfactants.	2007-09	17883892
Evidence for vesicle formation from 1:1 nonionic surfactant span 60 and fatty alcohol mixtures in aqueous ethanol: potential delivery vehicle composition.	2007-08-01	17412571
The use of solvent relaxation technique to investigate headgroup hydration and protein binding of simple and mixed phosphatidylcholine/surfactant bilayer membranes.	2007-05	17300743
Optimization of lipase-catalyzed synthesis of sorbitan acrylate using response surface methodology.	2007-04	18478419
Correlation between transcript profiles and fitness of deletion mutants in anaerobic chemostat cultures of Saccharomyces cerevisiae.	2007-03	17322208
Phase transition water-in-oil microemulsions as ocular drug delivery systems: in vitro and in vivo evaluation.	2007-01-02	17092668
Emulsifier content and side effects of oil-based adjuvant vaccine in swine.	2006-08	16337664
Water mass transfer in W/O emulsions.	2006-05-15	16298381
Composition analysis of two batches of polysorbate 60 using MS and NMR techniques.	2006-03-18	16280224
Enzymatic synthesis of sorbitan methacrylate according to acyl donors.	2006	16915646
Formulation and evaluation of a vitamin C multiple emulsion.	2006	16749536
Niosomes with sorbitan monoester as a carrier for vaginal delivery of insulin: studies in rats.	2005-10-29	16253956
Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products.	2005-10-15	16011869
Cationic niosomes as gene carriers: preparation and cellular uptake in vitro.	2005-06	15997841
Sorbitan monopalmitate-based proniosomes for transdermal delivery of chlorpheniramine maleate.	2005-04-13	15824032
Coupling aggressive mass removal with microbial reductive dechlorination for remediation of DNAPL source zones: a review and assessment.	2005-04	15811838
General one-step synthesis of free hexofuranosyl 1-phosphates using unprotected 1-thioimidoyl hexofuranosides.	2005-02-04	15675842
Formation and characterization of three-component-sorbitan monoester surfactant, oil and water-creams.	2004-01-09	14698594
Development and physical characterization of sorbitan monoester niosomes for insulin oral delivery.	2003-11-13	14612341
[Simultaneous analysis of four kinds of emulsifiers in beverages by GC/MS].	2003-02	12749192
A novel synthesis of D-galactofuranosyl, D-glucofuranosyl and D-mannofuranosyl 1-phosphates based on remote activation of new and free hexofuranosyl donors.	2002-12-16	12443765
Rheological properties of three component creams containing sorbitan monoesters as surfactants.	2002-10-24	12429489
Final report on the safety assessment of sorbitan caprylate, sorbitan cocoate, sorbitan diisostearate, sorbitan dioleate, sorbitan distearate, sorbitan isostearate, sorbitan olivate, sorbitan sesquiisostearate, sorbitan sesquistearate, and sorbitan triisostearate.	2002	12042063
Investigating the molecular heterogeneity of polysorbate emulsifiers by MALDI-TOF MS.	2001-07	11453772
Comparison of impact of the different hydrophilic carriers on the properties of piperazine-containing drug.	2001-05	11343886
Final report on the safety assessment of PEG-6, -8, and -20 sorbitan beeswax.	2001	11800050

Patents

Name

Type

Language

SORBITAN

Common Name

English

SORBITAN [II]

Preferred Name

English

Classification Tree Code System Code

CFR

21 CFR 175.320