1,4-Sorbitan is a sorbitol anhydration product. 1,4-Sorbitan is a precursor to environmentally benign surfactants. It is a component of Sorbitol-Sorbitan mixtures used as soft gel plasticizers. They enhance the soft gelatin capsule finish gloss for a premium appearance, help to prevent leakage, provide consistent pharmaceutical quality, and extend shelf life by maintaining a proper moisture balance within the capsule shell.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Final report on the safety assessment of sorbitan caprylate, sorbitan cocoate, sorbitan diisostearate, sorbitan dioleate, sorbitan distearate, sorbitan isostearate, sorbitan olivate, sorbitan sesquiisostearate, sorbitan sesquistearate, and sorbitan triisostearate. | 2002 |
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| A novel synthesis of D-galactofuranosyl, D-glucofuranosyl and D-mannofuranosyl 1-phosphates based on remote activation of new and free hexofuranosyl donors. | 2002 Dec 16 |
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| Rheological properties of three component creams containing sorbitan monoesters as surfactants. | 2002 Oct 24 |
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| General one-step synthesis of free hexofuranosyl 1-phosphates using unprotected 1-thioimidoyl hexofuranosides. | 2005 Feb 4 |
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| Cationic niosomes as gene carriers: preparation and cellular uptake in vitro. | 2005 Jun |
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| Sorbitan monopalmitate-based proniosomes for transdermal delivery of chlorpheniramine maleate. | 2005 Mar-Apr |
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| Niosomes with sorbitan monoester as a carrier for vaginal delivery of insulin: studies in rats. | 2005 Nov-Dec |
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| Formulation and evaluation of a vitamin C multiple emulsion. | 2006 |
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| Emulsifier content and side effects of oil-based adjuvant vaccine in swine. | 2006 Aug |
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| Composition analysis of two batches of polysorbate 60 using MS and NMR techniques. | 2006 Mar 18 |
|
| Water mass transfer in W/O emulsions. | 2006 May 15 |
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| Enzymatic synthesis of sorbitan methacrylate according to acyl donors. | 2006 Spring |
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| Phase transition water-in-oil microemulsions as ocular drug delivery systems: in vitro and in vivo evaluation. | 2007 Jan 2 |
|
| Dermal delivery of selected hydrophilic drugs from elastic liposomes: effect of phospholipid formulation and surfactants. | 2007 Sep |
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| Effect of water-in-oil microemulsions and lamellar liquid crystalline systems on the precorneal tear film of albino New Zealand rabbits. | 2008 Mar |
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| Between the devil and the deep blue sea: dispersants in the gulf of Mexico. | 2010 Aug |
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| Niosome as a drug carrier for topical delivery of N-acetyl glucosamine. | 2010 Jul |
|
| Application of liquid chromatography in polymer non-ionic antistatic additives analysis. | 2010 Nov |
Patents
| Substance Class |
Mixture
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| Record UNII |
6O92ICV9RU
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CFR |
21 CFR 175.320
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