PRINOMIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H13N3O2
Molecular Weight	267.2826
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C=CC=C1C(=O)C(C#N)C(=O)NC2=CC=CC=C2

InChI

InChIKey=KBQUAIAGRLAZGP-UHFFFAOYSA-N

InChI=1S/C15H13N3O2/c1-18-9-5-8-13(18)14(19)12(10-16)15(20)17-11-6-3-2-4-7-11/h2-9,12H,1H3,(H,17,20)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3266939 | https://www.ncbi.nlm.nih.gov/pubmed/8430060 | https://www.ncbi.nlm.nih.gov/pubmed/2903025 | https://www.ncbi.nlm.nih.gov/pubmed/2664168

Prinomide is a carbamoylpyrrolepropionitrile derivative patented by Ciba-Geigy A.-G. as a nonsteroidal anti-inflammatory drug that has disease-modifying activity in rheumatoid arthritis. In clinical trials, Prinomide demonstrate significant improvement in symptom score and laboratory variables.

Originator

Approval Year

PubMed

Title	Date	PubMed
Effect of a new antirheumatic drug (CGS10787B) on antibody formation and delayed-type hypersensitivity in BALB/c mice.	1988	3266939
Prinomide tromethamine pharmacokinetics: mutually dependent saturable and competitive protein binding between prinomide and its own metabolite.	1993 Jan	8430060

Patents

Sample Use Guides

In Vivo Use Guide

250, 500, and 1000 mg every 12 hr for 28 days to healthy male volunteers.

Route of Administration: Oral

Name

Type

Language

PRINOMIDE

Official Name

English

Prinomide [WHO-DD]

Common Name

English

prinomide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257