PRINOMIDE TROMETHAMINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H13N3O2.C4H11NO3
Molecular Weight	388.4177
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(CO)(CO)CO.CN1C=CC=C1C(=O)C(C#N)C(=O)NC2=CC=CC=C2

InChI

InChIKey=CPUJDORGQAJDCT-UHFFFAOYSA-N

InChI=1S/C15H13N3O2.C4H11NO3/c1-18-9-5-8-13(18)14(19)12(10-16)15(20)17-11-6-3-2-4-7-11;5-4(1-6,2-7)3-8/h2-9,12H,1H3,(H,17,20);6-8H,1-3,5H2

HIDE SMILES / InChI

Molecular Formula	C4H11NO3
Molecular Weight	121.135
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C15H13N3O2
Molecular Weight	267.2826
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3266939 | https://www.ncbi.nlm.nih.gov/pubmed/8430060 | https://www.ncbi.nlm.nih.gov/pubmed/2903025 | https://www.ncbi.nlm.nih.gov/pubmed/2664168

Prinomide is a carbamoylpyrrolepropionitrile derivative patented by Ciba-Geigy A.-G. as a nonsteroidal anti-inflammatory drug that has disease-modifying activity in rheumatoid arthritis. In clinical trials, Prinomide demonstrate significant improvement in symptom score and laboratory variables.

Originator

Approval Year

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

250, 500, and 1000 mg every 12 hr for 28 days to healthy male volunteers.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:28:55 GMT 2023` Edited by `admin` on `Fri Dec 15 15:28:55 GMT 2023`
Record UNII	33S1GFG04E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PRINOMIDE TROMETHAMINE

Official Name

English

CGS-10787D

Code

English

CGS 10787D

Code

English

PRINOMIDE TROMETHAMINE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710