PRINOMIDE TROMETHAMINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H13N3O2.C4H11NO3
Molecular Weight	388.4177
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(CO)(CO)CO.CN1C=CC=C1C(=O)C(C#N)C(=O)NC2=CC=CC=C2

InChI

InChIKey=CPUJDORGQAJDCT-UHFFFAOYSA-N

InChI=1S/C15H13N3O2.C4H11NO3/c1-18-9-5-8-13(18)14(19)12(10-16)15(20)17-11-6-3-2-4-7-11;5-4(1-6,2-7)3-8/h2-9,12H,1H3,(H,17,20);6-8H,1-3,5H2

HIDE SMILES / InChI

Molecular Formula	C15H13N3O2
Molecular Weight	267.2826
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	C4H11NO3
Molecular Weight	121.135
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3266939 | https://www.ncbi.nlm.nih.gov/pubmed/8430060 | https://www.ncbi.nlm.nih.gov/pubmed/2903025 | https://www.ncbi.nlm.nih.gov/pubmed/2664168

Prinomide is a carbamoylpyrrolepropionitrile derivative patented by Ciba-Geigy A.-G. as a nonsteroidal anti-inflammatory drug that has disease-modifying activity in rheumatoid arthritis. In clinical trials, Prinomide demonstrate significant improvement in symptom score and laboratory variables.

Originator

Approval Year

PubMed

Title	Date	PubMed
Prinomide tromethamine pharmacokinetics: mutually dependent saturable and competitive protein binding between prinomide and its own metabolite.	1993-01	8430060
Effect of a new antirheumatic drug (CGS10787B) on antibody formation and delayed-type hypersensitivity in BALB/c mice.	1988	3266939

Patents

Sample Use Guides

In Vivo Use Guide

250, 500, and 1000 mg every 12 hr for 28 days to healthy male volunteers.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:58:34 GMT 2025` Edited by `admin` on `Mon Mar 31 17:58:34 GMT 2025`
Record UNII	33S1GFG04E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CGS 10787D

Preferred Name

English

PRINOMIDE TROMETHAMINE

Official Name

English

CGS-10787D

Code

English

PRINOMIDE TROMETHAMINE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710