BAMIPINE LACTATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H24N2.C3H6O3
Molecular Weight	370.4852
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(O)C(O)=O.CN1CCC(CC1)N(CC2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=VUNFQOFEWHEROV-UHFFFAOYSA-N

InChI=1S/C19H24N2.C3H6O3/c1-20-14-12-19(13-15-20)21(18-10-6-3-7-11-18)16-17-8-4-2-5-9-17;1-2(4)3(5)6/h2-11,19H,12-16H2,1H3;2,4H,1H3,(H,5,6)

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Description
Sources: https://www.drugs.com/international/bamipine.html | http://en.pharmacodia.com/web/drug/1_12084.html

Bamipine (trade name Soventol) is a sedating antihistamine with pronounced sedative effects. Bamipine is a pharmaceutical drug acting as an H1 antihistamine with anticholinergic properties. It is used as an antipruritic ointment. Bamipine hydrochloride has been given by mouth. Bamipine, bamipine lactate, and bamipine salicylate have all been applied topically.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H1 receptor 315 Target ID: CHEMBL3943 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D07197 \| https://www.ncbi.nlm.nih.gov/pubmed/18977145	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Allergy 44 Sources: http://www.ndrugs.com/?s=bamipine http://www.druginfosys.com/drug.aspx?drugcode=1567&type=1	Primary		Approved 8429	Soventol Approved Use Allergic conditions

PubMed

Title	Date	PubMed
Hybrid approach for the design of highly affine and selective dopamine D(3) receptor ligands using privileged scaffolds of biogenic amine GPCR ligands.	2007 Dec 1	17826096
Antimycobacterial and H1-antihistaminic activity of 2-substituted piperidine derivatives.	2008 Dec 15	18977145

Patents

Sample Use Guides

In Vivo Use Guide

The recommended dose is 50-100 mg 3-4 times/day.

Route of Administration: Oral

In Vitro Use Guide

Bamipine treatment resulted in 29% of inhibition of Mycobacterium tuberculosis H37Rv (after 4 days by microplate alamar blue assay) at 6.25 ug/mL.

Name

Type

Language

BAMIPINE LACTATE

Common Name

English

MULTIFUNGIN COMPONENT BAMIPINE LACTATE

Brand Name

English

Bamipine lactate [WHO-DD]

Common Name

English

4-PIPERIDINAMINE, 1-METHYL-N-PHENYL-N-(PHENYLMETHYL)-, MONO(2-HYDROXYPROPANOATE)

Common Name

English

PROPANOIC ACID, 2-HYDROXY-, COMPD. WITH 1-METHYL-N-PHENYL-N-(PHENYLMETHYL)-4-PIPERIDINAMINE (1:1)

Common Name

English

BAMIPINE LACTATE COMPONENT OF MULTIFUNGIN

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578