BAMIPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H24N2
Molecular Weight	280.4073
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCC(CC1)N(CC2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=VZSXTYKGYWISGQ-UHFFFAOYSA-N

InChI=1S/C19H24N2/c1-20-14-12-19(13-15-20)21(18-10-6-3-7-11-18)16-17-8-4-2-5-9-17/h2-11,19H,12-16H2,1H3

HIDE SMILES / InChI

Molecular Formula	C19H24N2
Molecular Weight	280.4073
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/international/bamipine.html | http://en.pharmacodia.com/web/drug/1_12084.html

Bamipine (trade name Soventol) is a sedating antihistamine with pronounced sedative effects. Bamipine is a pharmaceutical drug acting as an H1 antihistamine with anticholinergic properties. It is used as an antipruritic ointment. Bamipine hydrochloride has been given by mouth. Bamipine, bamipine lactate, and bamipine salicylate have all been applied topically.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H1 receptor 315 Target ID: CHEMBL3943 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D07197 \| https://www.ncbi.nlm.nih.gov/pubmed/18977145	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Allergy 44 Sources: http://www.ndrugs.com/?s=bamipine http://www.druginfosys.com/drug.aspx?drugcode=1567&type=1	Primary		Approved 8429	Soventol Approved Use Allergic conditions

PubMed

Title	Date	PubMed
Hybrid approach for the design of highly affine and selective dopamine D(3) receptor ligands using privileged scaffolds of biogenic amine GPCR ligands.	2007 Dec 1	17826096
Antimycobacterial and H1-antihistaminic activity of 2-substituted piperidine derivatives.	2008 Dec 15	18977145

Patents

Sample Use Guides

In Vivo Use Guide

The recommended dose is 50-100 mg 3-4 times/day.

Route of Administration: Oral

In Vitro Use Guide

Bamipine treatment resulted in 29% of inhibition of Mycobacterium tuberculosis H37Rv (after 4 days by microplate alamar blue assay) at 6.25 ug/mL.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:50:13 GMT 2023` Edited by `admin` on `Sat Dec 16 17:50:13 GMT 2023`
Record UNII	Y6BHZ28O92
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BAMIPINE

Official Name

English

bamipine [INN]

Common Name

English

4-(N-BENZYLANILINO)-1-METHYLPIPERIDINE

Systematic Name

English

Bamipine [WHO-DD]

Common Name

English

BAMIPINE [MI]

Common Name

English

BAMIPINE [MART.]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QR06AX01