Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C9H6INO4S |
| Molecular Weight | 351.118 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=C(I)C=C(C2=CC=CN=C12)S(O)(=O)=O
InChI
InChIKey=ZBJWWKFMHOAPNS-UHFFFAOYSA-N
InChI=1S/C9H6INO4S/c10-6-4-7(16(13,14)15)5-2-1-3-11-8(5)9(6)12/h1-4,12H,(H,13,14,15)
8-Hydroxy-7-iodo-5-quinolinesulfonic acid (Ferron) showed fungistatic effect for Candida and for M. canis and T. mentagrophytes. Resotren is a chemical combination of chloroquine and iodohydroxyquinoline and, taken by mouth, is poorly absorbed and reaches the lower bowel in considerable concentration. Resotren is effective in both intestinal and extra-intestinal amoebiasis. Al-Ferron timed spectrophotometry assay is a basic method in the study on the formation of polynuclear hydroxyl aluminum species and their transformation laws in aqueous systems.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: GO:0006119 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Curative | Resotren Approved UseIndicated for the treatment of amoebic dysentery, ulcerative colitis, intestinal infections; purulent wounds, ulcers, burns; acute, chronic articular rheumatism and in gynecological and urological practice. |
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| Primary | Unknown Approved UseIndicated for the treatment of amoebic dysentery, ulcerative colitis, intestinal infections; purulent wounds, ulcers, burns; acute, chronic articular rheumatism and in gynecological and urological practice. |
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| Primary | Unknown Approved UseIndicated for the treatment of amoebic dysentery, ulcerative colitis, intestinal infections; purulent wounds, ulcers, burns; acute, chronic articular rheumatism and in gynecological and urological practice. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Evaluation by contrast-enhanced MR imaging of the lateral border zone in reperfused myocardial infarction in a cat model. | 2001 Jan-Mar |
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| Predicting toxicity of tall larkspur (Delphinium barbeyi): measurement of the variation in alkaloid concentration among plants and among years. | 2002 Nov |
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| [Speciation and characterization of interaction of PACls with sulfate]. | 2003 Jul |
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| Antineoplastic and antibacterial activity of some mononuclear Ru(II) complexes. | 2004 Apr |
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| Hydrogen-bonded supramolecular motifs in 4,4'-bipyridinium 8-hydroxy-7-iodoquinoline-5-sulfonate dihydrate. | 2004 Apr |
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| [Assay of three kinds of aluminum fractions (Al(a), Al(b) and Al(c)) in polynuclear aluminum solutions by Al-Ferron timed spectrophotometry and demarcation of their time limits]. | 2005 Feb |
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| The modeled structure of the RNA dependent RNA polymerase of GBV-C virus suggests a role for motif E in Flaviviridae RNA polymerases. | 2005 Oct 14 |
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| Effect of citric acid on aluminum hydrolytic speciation. | 2005 Sep |
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| Ischemic preconditioning: protection against myocardial necrosis and apoptosis. | 2007 |
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| Relative importance of hydrolyzed Al(III) species (Al(a), Al(b), and Al(c)) during coagulation with polyaluminum chloride: a case study with the typical micro-polluted source waters. | 2007 Dec 15 |
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| A generalized analysis of hydrophobic and loop clusters within globular protein sequences. | 2007 Jan 8 |
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| Proton-transfer compounds of 8-hydroxy-7-iodoquinoline-5-sulfonic acid (ferron) with 4-chloroaniline and 4-bromoaniline. | 2007 Jul |
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| Simulation of developmental changes in action potentials with ventricular cell models. | 2007 Mar |
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| Enhanced coagulation with polyaluminum chlorides: role of pH/alkalinity and speciation. | 2008 Apr |
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| Glucose-insulin therapy, plasma substrate levels and cardiac recovery after cardiac ischemic events. | 2008 Apr |
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| The novel adipocytokine visfatin exerts direct cardioprotective effects. | 2008 Aug |
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| Occupational exposures and non-Hodgkin's lymphoma: Canadian case-control study. | 2008 Aug 7 |
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| 3-Amino-pyridinium 4-hydr-oxy-3-iodo-naphthalene-1-sulfonate dihydrate. | 2008 May 17 |
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| Effect of vitamin K supplementation on insulin resistance in older men and women. | 2008 Nov |
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| [Al species distribution of organic silicate aluminum hybrid flocculants by Al-ferron complexation timed spectrophotometric method]. | 2008 Sep |
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| Impaired leukocyte influx in cervix of postterm women not responding to prostaglandin priming. | 2008 Sep 2 |
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| Characterization of hydrolyzed Fe(III) species produced in Fenton's reaction. | 2009 Dec 14 |
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| Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database. | 2009 Dec 3 |
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| Comparison of coagulation behavior and floc structure characteristic of different polyferric-cationic polymer dual-coagulants in humic acid solution. | 2009 Feb |
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| k-Value-based ferron assay and its application. | 2009 Jul 1 |
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| Ethnicity and incidence of Hodgkin lymphoma in Canadian population. | 2009 May 11 |
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| Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum. | 2009 Sep 1 |
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| Grand challenges in bone endocrinology. | 2010 |
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| Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine. | 2010 |
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| Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project. | 2010 |
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| Visfatin/PBEF/Nampt: A New Cardiovascular Target? | 2010 |
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| Low HDL Cholesterol is Associated with Lower Gray Matter Volume in Cognitively Healthy Adults. | 2010 |
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| Using small-scale studies to prioritize threats and guide recovery of a rare hemiparasitic plant: Cordylanthus rigidus ssp. littoralis. | 2010 Jan 26 |
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| No bones about it: insulin modulates skeletal remodeling. | 2010 Jul 23 |
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| In the shadow of a new smoke free policy: A discourse analysis of health care providers' engagement in tobacco control in community mental health. | 2010 Jul 28 |
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| Mutation of actin Tyr-53 alters the conformations of the DNase I-binding loop and the nucleotide-binding cleft. | 2010 Mar 26 |
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| Catestatin improves post-ischemic left ventricular function and decreases ischemia/reperfusion injury in heart. | 2010 Nov |
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| Conformational dynamics of actin: effectors and implications for biological function. | 2010 Oct |
Patents
Sample Use Guides
Usually a course of resotren consisted of 40 tablets given as follows:
1st day - 3x2 tablet=6
2nd-5th day - 4x1 tablet=16
6th-10th day - 3x1 tablet=15
11th-12th day - 3x0.5 tablet=3
resotren tablet contains 0.5 g of cloquinate
Route of Administration:
Oral
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m6135
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SALT/SOLVATE (PARENT)
SUBSTANCE RECORD
