Sodium 8-hydroxy-7-iodoquinoline-5-sulfonate

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H5INO4S.Na
Molecular Weight	373.1
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of Sodium 8-hydroxy-7-iodoquinoline-5-sulfonate

Structure Search

SMILES

[Na+].OC1=C(I)C=C(C2=CC=CN=C12)S([O-])(=O)=O

InChI

InChIKey=NWAPYWBKEFRREH-UHFFFAOYSA-M

InChI=1S/C9H6INO4S.Na/c10-6-4-7(16(13,14)15)5-2-1-3-11-8(5)9(6)12;/h1-4,12H,(H,13,14,15);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	C9H5INO4S
Molecular Weight	350.11
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13320934 | https://www.ncbi.nlm.nih.gov/pubmed/28159993 | https://www.ncbi.nlm.nih.gov/pubmed/15852869 | https://www.ncbi.nlm.nih.gov/pubmed/18742353

8-Hydroxy-7-iodo-5-quinolinesulfonic acid (Ferron) showed fungistatic effect for Candida and for M. canis and T. mentagrophytes. Resotren is a chemical combination of chloroquine and iodohydroxyquinoline and, taken by mouth, is poorly absorbed and reaches the lower bowel in considerable concentration. Resotren is effective in both intestinal and extra-intestinal amoebiasis. Al-Ferron timed spectrophotometry assay is a basic method in the study on the formation of polynuclear hydroxyl aluminum species and their transformation laws in aqueous systems.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
oxidative phosphorylation 6 Target ID: GO:0006119 Sources: http://www.rusmedserv.com/lekarstva/komponent/chiniofon.html	Inhibitor 8504

Conditions

Condition	Modality	Highest Phase	Product
Amoebiasis 12 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13320934 https://www.ncbi.nlm.nih.gov/pubmed/29015578	Curative	Not Provided 511	Resotren Approved Use Indicated for the treatment of amoebic dysentery, ulcerative colitis, intestinal infections; purulent wounds, ulcers, burns; acute, chronic articular rheumatism and in gynecological and urological practice.
Wounds 16 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7607895 https://www.rlsnet.ru/mnn_index_id_1381.htm	Primary	Not Provided 511	Unknown Approved Use Indicated for the treatment of amoebic dysentery, ulcerative colitis, intestinal infections; purulent wounds, ulcers, burns; acute, chronic articular rheumatism and in gynecological and urological practice.
Ulcerative colitis 125 Sources: http://www.pamba.ru/therapeutic/antimicrobial/oxin/chiniofon/ http://www.rusmedserv.com/lekarstva/komponent/chiniofon.html	Primary	Not Provided 511	Unknown Approved Use Indicated for the treatment of amoebic dysentery, ulcerative colitis, intestinal infections; purulent wounds, ulcers, burns; acute, chronic articular rheumatism and in gynecological and urological practice.

PubMed

Title	Date	PubMed
Catestatin improves post-ischemic left ventricular function and decreases ischemia/reperfusion injury in heart.	2010-11	21104119
Aluminum polymers formed following alum treatment of lake water.	2010-11	20825969
Conformational dynamics of actin: effectors and implications for biological function.	2010-10	20672362
The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription.	2010-09-16	20862324
[Comparative study on the coagulation of PACl with different contents of aluminum polymeric species].	2010-08	21090298
In the shadow of a new smoke free policy: A discourse analysis of health care providers' engagement in tobacco control in community mental health.	2010-07-28	20667105
No bones about it: insulin modulates skeletal remodeling.	2010-07-23	20655463
Integrative physiology: defined novel metabolic roles of osteocalcin.	2010-07	20592887
Mutation of actin Tyr-53 alters the conformations of the DNase I-binding loop and the nucleotide-binding cleft.	2010-03-26	20100837
Using small-scale studies to prioritize threats and guide recovery of a rare hemiparasitic plant: Cordylanthus rigidus ssp. littoralis.	2010-01-26	20126657
Grand challenges in bone endocrinology.	2010	22649353
Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine.	2010	22291509
Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project.	2010	22291486
Visfatin/PBEF/Nampt: A New Cardiovascular Target?	2010	21833174
Low HDL Cholesterol is Associated with Lower Gray Matter Volume in Cognitively Healthy Adults.	2010	20725527
Characterization of hydrolyzed Fe(III) species produced in Fenton's reaction.	2009-12-14	20184003
Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database.	2009-12-03	19959591
Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum.	2009-09-01	19185052
k-Value-based ferron assay and its application.	2009-07-01	19419729
Study on the hydrolysis/precipitation behavior of Keggin Al13 and Al30 polymers in polyaluminum solutions.	2009-06	19409689
Ethnicity and incidence of Hodgkin lymphoma in Canadian population.	2009-05-11	19432977
Clustering of cancer among families of cases with Hodgkin Lymphoma (HL), Multiple Myeloma (MM), Non-Hodgkin's Lymphoma (NHL), Soft Tissue Sarcoma (STS) and control subjects.	2009-02-27	19250521
Comparison of coagulation behavior and floc structure characteristic of different polyferric-cationic polymer dual-coagulants in humic acid solution.	2009-02	19046756
Preparation of high concentration polyaluminum chloride with high content of Alb or Alc.	2009	19999987
Hydrolysis and coagulation behavior of polyferric sulfate and ferric sulfate.	2009	19342808
Modified ferron assay for speciation characterization of hydrolyzed Al(III): a precise k value based judgment.	2009	19237778
Effect of vitamin K supplementation on insulin resistance in older men and women.	2008-11	18697901
Impaired leukocyte influx in cervix of postterm women not responding to prostaglandin priming.	2008-09-02	18764934
[Al species distribution of organic silicate aluminum hybrid flocculants by Al-ferron complexation timed spectrophotometric method].	2008-09	19068635
Model for the deposition of aerosol particles in the respiratory tract of the rat. I. Nonhygroscopic particle deposition.	2008-09	18627243
Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.	2008-09	18559663
Occupational exposures and non-Hodgkin's lymphoma: Canadian case-control study.	2008-08-07	18687133
Wake up and smell the coffee: yet another no go for cardiac patients? : editorial to "caffeinated coffee blunts the myocardial protective effects of statins against ischemia-reperfusion injury in the rat" by Ye et al.	2008-08	18415673
The novel adipocytokine visfatin exerts direct cardioprotective effects.	2008-08	18400051
OnD-CRF: predicting order and disorder in proteins using [corrected] conditional random fields.	2008-06-01	18430742
3-Amino-pyridinium 4-hydr-oxy-3-iodo-naphthalene-1-sulfonate dihydrate.	2008-05-17	21202620
Enhanced coagulation with polyaluminum chlorides: role of pH/alkalinity and speciation.	2008-04	18328534
Glucose-insulin therapy, plasma substrate levels and cardiac recovery after cardiac ischemic events.	2008-04	18266096
Relative importance of hydrolyzed Al(III) species (Al(a), Al(b), and Al(c)) during coagulation with polyaluminum chloride: a case study with the typical micro-polluted source waters.	2007-12-15	17888935
Highly selective and sensitized spectrophotometric determination of iron (III) following potentiometric study.	2007-09	17970298
Proton-transfer compounds of 8-hydroxy-7-iodoquinoline-5-sulfonic acid (ferron) with 4-chloroaniline and 4-bromoaniline.	2007-07	17609572
Simulation of developmental changes in action potentials with ventricular cell models.	2007-03	19003434
A generalized analysis of hydrophobic and loop clusters within globular protein sequences.	2007-01-08	17210072
Ischemic preconditioning: protection against myocardial necrosis and apoptosis.	2007	18078014
Analytical methods for PCBs and organochlorine pesticides in environmental monitoring and surveillance: a critical appraisal.	2006-10	17047943
Al(III) speciation distribution and transformation in high concentration PACl solutions.	2006	17278740
The modeled structure of the RNA dependent RNA polymerase of GBV-C virus suggests a role for motif E in Flaviviridae RNA polymerases.	2005-10-14	16225688
Effect of citric acid on aluminum hydrolytic speciation.	2005-09	16112170
Migration and mental health in Europe (the state of the mental health in Europe working group: appendix 1).	2005-08-31	16135246
Dual emission probe for luminescence oxygen sensing: a critical comparison between intensity, lifetime and ratiometric measurements.	2005-04-30	18970028

Patents

Sample Use Guides

In Vivo Use Guide

Usually a course of resotren consisted of 40 tablets given as follows: 1st day - 3x2 tablet=6 2nd-5th day - 4x1 tablet=16 6th-10th day - 3x1 tablet=15 11th-12th day - 3x0.5 tablet=3 resotren tablet contains 0.5 g of cloquinate

Route of Administration: Oral

In Vitro Use Guide

8-hydroxy-7-iodo-5-quinolinesulfonic acid demonstrated MIC50 for Candid glabrata and C.krusei is 16 ug/ml but for C.albicans, C.parapsilosis and C.tropicals is 64 ug/ml.

Substance Class	Chemical Created by `admin` on `Tue Apr 01 20:17:47 GMT 2025` Edited by `admin` on `Tue Apr 01 20:17:47 GMT 2025`
Record UNII	SV4ZN7T8M7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

5-Quinolinesulfonic acid, 8-hydroxy-7-iodo-, sodium salt

Preferred Name

English

Sodium 8-hydroxy-7-iodoquinoline-5-sulfonate

Systematic Name

English

Code System Code Type Description

FDA UNII

SV4ZN7T8M7