Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C22H26NO2.Na |
| Molecular Weight | 359.4371 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[O-]C(=O)CCCCCCNC1C2=CC=CC=C2CCC3=C1C=CC=C3
InChI
InChIKey=RXWWSYJKVIBAAU-UHFFFAOYSA-M
InChI=1S/C22H27NO2.Na/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22;/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25);/q;+1/p-1
Amineptine is a selective inhibitor of dopamine reuptake. The drug was developed in France and was marketed for the treatment of depressive disorders under the name Survector among the others. Amineptine was withdrawn from the French market in 1999 because of abuse and drug dependence and because of its hepatic (cholestatic injuries) and cutaneous (acne) adverse effects.
CNS Activity
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Extensive multicentric study of 1354 cases of depressed subjects treated with amineptin]. | 1982 |
|
| [A study of three potential antidepressants (amineptin, mianserin and nomifensin) on the cardiovascular system and isolated intestine (author's transl)]. | 1982 Jun 10 |
|
| [Rosaceous drug eruption caused by amineptin (Survector)]. | 1988 |
|
| [Amineptin dependence. Detection of patients at risk. Report of 8 cases]. | 1990 Sep-Oct |
|
| [Amineptin dependence and iatrogenic acne. Review of the literature apropos of a case]. | 1991 Dec |
|
| [Immediate acute hepatic cytolysis after the administration of a single amineptin tablet]. | 1992 |
|
| WHO Expert Committee on Drug Dependence. Thirty-second report. | 2001 |
|
| Treatment for amphetamine withdrawal. | 2001 |
|
| Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction. | 2001 |
|
| [Liver damage and nonsteroidal anti-inflammatory drugs: case non-case study in the French Pharmacovigilance Database]. | 2001 Jan-Feb |
|
| Acneiform eruption caused by amineptine. A case report and review of the literature. | 2001 Jul |
|
| Social stress in anorexia nervosa: a review of immuno-endocrine relationships. | 2001 Jun |
|
| Dopaminergic augmentation of sleep deprivation effects in bipolar depression. | 2001 Nov 30 |
|
| Methylphenidate in stimulants abuse: three case reports. | 2001 Spring |
|
| WHO Expert Committee on Drug Dependence. | 2003 |
|
| Benefits and risks of pharmacotherapy for dysthymia: a systematic appraisal of the evidence. | 2003 |
|
| Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice. | 2003 Jul |
|
| Role of presynaptic alpha2-adrenoceptors in antidepressant action: recent findings from microdialysis studies. | 2004 Aug |
|
| Discriminating different classes of toxicants by transcript profiling. | 2004 Aug |
|
| Fluoxetine dependence in a former amineptine abuser. | 2004 Oct-Dec |
|
| Antidepressants for anorexia nervosa. | 2006 Jan 25 |
|
| Spectrophotometric determination of trazodone, amineptine and amitriptyline hydrochlorides through ion-pair formation using methyl orange and bromocresol green reagents. | 2006 Sep |
|
| Venlafaxine dependence in a patient with a history of alcohol and amineptine misuse. | 2008 Sep |
|
| Update on the management of symptoms in schizophrenia: focus on amisulpride. | 2009 |
|
| [Acne induced by amineptine]. | 2009 Jan-Feb |
|
| Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010 Dec |
|
| Molecular biology research in neuropsychiatry: India's contribution. | 2010 Jan |
Patents
Sample Use Guides
Patients receive 200 mg of amineptine (survector) daily, in two divided doses at 8 A.M. and 12 noon for 6 weeks.
Route of Administration:
Oral
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100000085154
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SUB00448MIG
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68946-01-0
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ACTIVE MOIETY
SUBSTANCE RECORD
