NEPINALONE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H25NO.ClH
Molecular Weight	307.858
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC2(CCN1CCCCC1)C(=O)CCC3=C2C=CC=C3

InChI

InChIKey=DWXUSWVHSCQVTM-UHFFFAOYSA-N

InChI=1S/C18H25NO.ClH/c1-18(11-14-19-12-5-2-6-13-19)16-8-4-3-7-15(16)9-10-17(18)20;/h3-4,7-8H,2,5-6,9-14H2,1H3;1H

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22711801 | https://www.codifa.it/farmaci/n/nepituss-nepinalone-antitussivi | https://moh-it.pure.elsevier.com/en/publications/antitussive-activity-of-l-and-d-isomers-of-nepinalone-vs-racemus-

Nepinalone is a new alchilaminate derivative of β-tetralone, which possess a non-opioid antitussive activity. Nepinalone racemus exerted a significant antitussive activity and both L- and D-isomers confirmed to possess a significant dose-correlated antitussive effect with better trend of activity for D-isomer, but not statistically significant. It was predicted to act via sigma receptors. Occasionally, episodes of gastric intolerance have been reported and rapidly receded when treatment was stopped. The use of doses higher than those recommended could cause drowsiness.

Approval Year

Patents

Sample Use Guides

In Vivo Use Guide

Single dose - 2, 4, 8 mg/kg

Route of Administration: Intraperitoneal

Name

Type

Language

NEPINALONE HYDROCHLORIDE

Common Name

English

2(1H)-NAPHTHALENONE, 3,4-DIHYDRO-1-METHYL-1-(2-(1-PIPERIDINYL)ETHYL)-, HYDROCHLORIDE (1:1)

Preferred Name

English

Nepinalone Hydrochloride [WHO-DD]

Common Name

English

Code System Code Type Description

SMS_ID

100000093025