Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C9H9NO3.2Na.2H2O |
| Molecular Weight | 261.1828 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.[Na+].[Na+].N[C@@H](CC1=CC=C([O-])C=C1)C([O-])=O
InChI
InChIKey=WFTCFVUQORELJZ-USHJOAKVSA-L
InChI=1S/C9H11NO3.2Na.2H2O/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;;;;/h1-4,8,11H,5,10H2,(H,12,13);;;2*1H2/q;2*+1;;/p-2/t8-;;;;/m0..../s1
Tyrosine (L-form) is a non-essential amino acid, which is primarily required for the protein synthesis. This amino acid is the precursor of dopamine, norepinephrine, and epinephrine; therefore the lower concentration of tyrosine could be a peripheral marker of the hyperdopaminergic condition hypothesized to explain psychosis. Tyrosine supplements can improve cognition, increase energy, reduce anxiety, reduce depression, reduce levels of pain.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: Protein biosynthesis |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | AMINOSYN Approved UseAminosyn, Sulfite-Free, (a crystalline amino acid solution) infused with dextrose by peripheral vein infusion is indicated as a source of nitrogen in the nutritional support of patients with adequate stores of body fat, in whom, for short periods of time, oral nutrition cannot be tolerated, is undesirable, or inadequate. Launch Date1975 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Identification of receptor tyrosine kinase associating proteins using the yeast two-hybrid system. | 2001 |
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| Identification of receptor tyrosine kinase (RTK) substrates by the cloning of receptor targets (CORT) strategy. | 2001 |
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| Cloning protein tyrosine kinases by screening cDNA libraries with antiphosphotyrosine antibodies. | 2001 |
|
| Synthesis and use of DNA containing a 5'-bridging phosphorothioate as a suicide substrate for type I DNA topoisomerases. | 2001 |
|
| The Src kinase p56(lck) up-regulates VLA-4 integrin affinity. Implications for rapid spontaneous and chemokine-triggered T cell adhesion to VCAM-1 and fibronectin. | 2001 Apr 27 |
|
| The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner. | 2001 Feb 16 |
|
| Glycosylation-induced conformational modification positively regulates receptor-receptor association: a study with an aberrant epidermal growth factor receptor (EGFRvIII/DeltaEGFR) expressed in cancer cells. | 2001 Feb 16 |
|
| Divergent roles of SHP-2 in ERK activation by leptin receptors. | 2001 Feb 16 |
|
| Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation. | 2001 Feb 16 |
|
| Role of dynamin, Src, and Ras in the protein kinase C-mediated activation of ERK by gonadotropin-releasing hormone. | 2001 Feb 16 |
|
| Integrin-independent tyrosine phosphorylation of p125(fak) in human platelets stimulated by collagen. | 2001 Feb 2 |
|
| Activation of Rho is required for ligand-independent oncogenic signaling by a mutant epidermal growth factor receptor. | 2001 Feb 2 |
|
| The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton. | 2001 Feb 23 |
|
| T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4. | 2001 Feb 23 |
|
| A model of platelet aggregation involving multiple interactions of thrombospondin-1, fibrinogen, and GPIIbIIIa receptor. | 2001 Feb 23 |
|
| Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway. | 2001 Feb 23 |
|
| Biochemical and immunohistological changes in the brain of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse. | 2001 Jan |
|
| Abnormal localisation and hyperclustering of (alpha)(V)(beta)(3) integrins and associated proteins in Src-deficient or tyrphostin A9-treated osteoclasts. | 2001 Jan |
|
| The common Arg972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets. | 2001 Jan |
|
| Phosphatidylinositol-3 kinase acts in parallel to the ERK MAP kinase in the FGF pathway during Xenopus mesoderm induction. | 2001 Jan |
|
| IDA-1, a Caenorhabditis elegans homolog of the diabetic autoantigens IA-2 and phogrin, is expressed in peptidergic neurons in the worm. | 2001 Jan 1 |
|
| Structure of longitudinal brain zones that provide the origin for the substantia nigra and ventral tegmental area in human embryos, as revealed by cytoarchitecture and tyrosine hydroxylase, calretinin, calbindin, and GABA immunoreactions. | 2001 Jan 1 |
|
| EPR studies of the water oxidizing complex in the S1 and the higher S states: the manganese cluster and Y(Z) radical. | 2001 Jan 5 |
|
| EPR/ENDOR characterization of the physical and electronic structure of the OEC Mn cluster. | 2001 Jan 5 |
|
| Vibrational spectroscopy of the oxygen-evolving complex and of manganese model compounds. | 2001 Jan 5 |
|
| Metallo-radical hypothesis for photoassembly of (Mn)4-cluster of photosynthetic oxygen evolving complex. | 2001 Jan 5 |
|
| Okadaic acid-induced upregulation of nitrotyrosine and heme oxygenase-1 in rat cortical neuron cultures. | 2001 Jan 5 |
|
| Effects of tumor necrosis factor alpha on taurine uptake in cultured rat astrocytes. | 2001 Mar |
|
| Differential regulation of alternatively spliced endothelial cell myosin light chain kinase isoforms by p60(Src). | 2001 Mar 16 |
|
| Cellular stress induces the tyrosine phosphorylation of caveolin-1 (Tyr(14)) via activation of p38 mitogen-activated protein kinase and c-Src kinase. Evidence for caveolae, the actin cytoskeleton, and focal adhesions as mechanical sensors of osmotic stress. | 2001 Mar 16 |
|
| The rat liver Na(+)/bile acid cotransporter. Importance of the cytoplasmic tail to function and plasma membrane targeting. | 2001 Mar 2 |
|
| Essential tyrosine residues for interaction of the non-receptor protein-tyrosine phosphatase PTP1B with N-cadherin. | 2001 Mar 2 |
|
| Multiple regions of MAP kinase phosphatase 3 are involved in its recognition and activation by ERK2. | 2001 Mar 2 |
|
| Insufficient phosphorylation prevents fc gamma RIIB from recruiting the SH2 domain-containing protein-tyrosine phosphatase SHP-1. | 2001 Mar 2 |
|
| Altered regulation of cell cycle machinery involved in interleukin-1-induced G(1) and G(2) phase growth arrest of A375S2 human melanoma cells. | 2001 Mar 2 |
|
| Epidermal growth factor receptor-dependent control of keratinocyte survival and Bcl-xL expression through a MEK-dependent pathway. | 2001 Mar 2 |
|
| Fibrin clot retraction by human platelets correlates with alpha(IIb)beta(3) integrin-dependent protein tyrosine dephosphorylation. | 2001 Mar 2 |
|
| ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks. | 2001 Mar 23 |
|
| Cloning of ACP33 as a novel intracellular ligand of CD4. | 2001 Mar 23 |
|
| Contrasting localizations of MALS/LIN-7 PDZ proteins in brain and molecular compensation in knockout mice. | 2001 Mar 23 |
|
| Functional relationships between capacitation-dependent cell signaling and compartmentalized metabolic pathways in murine spermatozoa. | 2001 Mar 9 |
|
| PU.1 is a lineage-specific regulator of tyrosine phosphatase CD45. | 2001 Mar 9 |
|
| Regulation of ROMK1 channels by protein-tyrosine kinase and -tyrosine phosphatase. | 2001 Mar 9 |
|
| An interaction between ricin and calreticulin that may have implications for toxin trafficking. | 2001 Mar 9 |
|
| Stimulation of extracellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone is protein kinase C-dependent. | 2001 Mar 9 |
|
| Inhibition of osteoclast function by adenovirus expressing antisense protein-tyrosine kinase 2. | 2001 Mar 9 |
|
| The basis of prostaglandin synthesis in coral: molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosa. | 2001 Mar 9 |
|
| Mechanism of stimulation of osteoclastic bone resorption through Gas6/Tyro 3, a receptor tyrosine kinase signaling, in mouse osteoclasts. | 2001 Mar 9 |
|
| CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration. | 2001 Mar 9 |
|
| The two major plant plasma membrane H+-ATPases display different regulatory properties. | 2001 Mar 9 |
Patents
Sample Use Guides
In adults, tyrosine (Aminosyn solution) is given for nutritional maintenance via peripheral vein at a final amino acid concentration of 3.5, 4.25 or 5% together with dextrose in concentrations of 5% to 10%. 5%, 7%, 8.5% and 10% solutions should only be infused via a central vein when admixed with sufficient dextrose. In pediatric patients, the amino acid mixture is administered in a 2.5% concentration.
Route of Administration:
Intravenous
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SUB180155
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100000166121
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5RFD27DQ22
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DTXSID50153676
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71587456
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122666-87-9
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ACTIVE MOIETY
SUBSTANCE RECORD
