Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H11N3.C4H2O4 |
| Molecular Weight | 311.2921 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | -2 |
SHOW SMILES / InChI
SMILES
[O-]C(=O)\C=C\C([O-])=O.CC1=C(CC#N)N=C(N1)C2=CC=CC=C2
InChI
InChIKey=BACLFYJGAMBEIX-WLHGVMLRSA-L
InChI=1S/C12H11N3.C4H4O4/c1-9-11(7-8-13)15-12(14-9)10-5-3-2-4-6-10;5-3(6)1-2-4(7)8/h2-6H,7H2,1H3,(H,14,15);1-2H,(H,5,6)(H,7,8)/p-2/b;2-1+
DescriptionCurator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/3999024 | https://www.ncbi.nlm.nih.gov/pubmed/3749246
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/3999024 | https://www.ncbi.nlm.nih.gov/pubmed/3749246
Mefenidil has been reported to be a selective cerebral vasodilator. It significantly increased cerebral blood flow (without stimulation of O2 uptake) and lowered cerebral vascular resistance without having significant effects in other circulatory regions. Increase in cerebral blood flow is not mediated via the beta-adrenergic receptor as the effect was not blocked by propranolol. However, the clinical usefulness of mefenidil as a cerebral vasodilator may be limited by the accompanying arterial hypotension due to systemic vasodilation, which was most prominent in heart and gut.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cardiovascular profile of 5-methyl-2-phenyl-4-imidazole-acetonitrile (MCN-2378), a cerebral vasodilator. | 1975 Jan |
|
| Effect of mefenidil on cerebral and peripheral hemodynamics in dogs. | 1985 May |
|
| Effects of mefenidil hydrochloride on cerebral blood flow in conscious and anesthetized rat. | 1986 |
Sample Use Guides
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NCI_THESAURUS |
C29707
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5QH19BF6YG
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83153-38-2
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CHEMBL2106836
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U-24
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6440686
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C66073
Created by
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ACTIVE MOIETY
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
