Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H11N3.C4H2O4 |
| Molecular Weight | 311.2921 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | -2 |
SHOW SMILES / InChI
SMILES
[O-]C(=O)\C=C\C([O-])=O.CC1=C(CC#N)N=C(N1)C2=CC=CC=C2
InChI
InChIKey=BACLFYJGAMBEIX-WLHGVMLRSA-L
InChI=1S/C12H11N3.C4H4O4/c1-9-11(7-8-13)15-12(14-9)10-5-3-2-4-6-10;5-3(6)1-2-4(7)8/h2-6H,7H2,1H3,(H,14,15);1-2H,(H,5,6)(H,7,8)/p-2/b;2-1+
DescriptionCurator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/3999024 | https://www.ncbi.nlm.nih.gov/pubmed/3749246
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/3999024 | https://www.ncbi.nlm.nih.gov/pubmed/3749246
Mefenidil has been reported to be a selective cerebral vasodilator. It significantly increased cerebral blood flow (without stimulation of O2 uptake) and lowered cerebral vascular resistance without having significant effects in other circulatory regions. Increase in cerebral blood flow is not mediated via the beta-adrenergic receptor as the effect was not blocked by propranolol. However, the clinical usefulness of mefenidil as a cerebral vasodilator may be limited by the accompanying arterial hypotension due to systemic vasodilation, which was most prominent in heart and gut.
Originator
Approval Year
Sample Use Guides
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NCI_THESAURUS |
C29707
Created by
admin on Fri Dec 15 16:30:53 GMT 2023 , Edited by admin on Fri Dec 15 16:30:53 GMT 2023
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5QH19BF6YG
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83153-38-2
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CHEMBL2106836
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U-24
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6440686
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C66073
Created by
admin on Fri Dec 15 16:30:53 GMT 2023 , Edited by admin on Fri Dec 15 16:30:53 GMT 2023
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ACTIVE MOIETY
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
