Details
Stereochemistry | ACHIRAL |
Molecular Formula | C12H11N3.C4H2O4 |
Molecular Weight | 311.2921 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Charge | -2 |
SHOW SMILES / InChI
SMILES
[O-]C(=O)\C=C\C([O-])=O.CC1=C(CC#N)N=C(N1)C2=CC=CC=C2
InChI
InChIKey=BACLFYJGAMBEIX-WLHGVMLRSA-L
InChI=1S/C12H11N3.C4H4O4/c1-9-11(7-8-13)15-12(14-9)10-5-3-2-4-6-10;5-3(6)1-2-4(7)8/h2-6H,7H2,1H3,(H,14,15);1-2H,(H,5,6)(H,7,8)/p-2/b;2-1+
Molecular Formula | C4H4O4 |
Molecular Weight | 116.0722 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Optical Activity | NONE |
Molecular Formula | C12H11N3 |
Molecular Weight | 197.2358 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/1122930Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/3999024 | https://www.ncbi.nlm.nih.gov/pubmed/3749246
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1122930
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/3999024 | https://www.ncbi.nlm.nih.gov/pubmed/3749246
Mefenidil has been reported to be a selective cerebral vasodilator. It significantly increased cerebral blood flow (without stimulation of O2 uptake) and lowered cerebral vascular resistance without having significant effects in other circulatory regions. Increase in cerebral blood flow is not mediated via the beta-adrenergic receptor as the effect was not blocked by propranolol. However, the clinical usefulness of mefenidil as a cerebral vasodilator may be limited by the accompanying arterial hypotension due to systemic vasodilation, which was most prominent in heart and gut.
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Cardiovascular profile of 5-methyl-2-phenyl-4-imidazole-acetonitrile (MCN-2378), a cerebral vasodilator. | 1975 Jan |
|
Effect of mefenidil on cerebral and peripheral hemodynamics in dogs. | 1985 May |
|
Effects of mefenidil hydrochloride on cerebral blood flow in conscious and anesthetized rat. | 1986 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1122930
Curator's Comment: McN-2378 caused a more pronounced effect on cerebral blood flow than on femoral blood flow at the 2.5 and 5.0 mg/kg i.v. doses and this effect was significantly more prolonged at these doses.
Rhesus monkey: 2.5-5.0 mg/kg
Route of Administration:
Intravenous
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:30:53 GMT 2023
by
admin
on
Fri Dec 15 16:30:53 GMT 2023
|
Record UNII |
5QH19BF6YG
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C29707
Created by
admin on Fri Dec 15 16:30:53 GMT 2023 , Edited by admin on Fri Dec 15 16:30:53 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
5QH19BF6YG
Created by
admin on Fri Dec 15 16:30:53 GMT 2023 , Edited by admin on Fri Dec 15 16:30:53 GMT 2023
|
PRIMARY | |||
|
83153-38-2
Created by
admin on Fri Dec 15 16:30:53 GMT 2023 , Edited by admin on Fri Dec 15 16:30:53 GMT 2023
|
PRIMARY | |||
|
CHEMBL2106836
Created by
admin on Fri Dec 15 16:30:53 GMT 2023 , Edited by admin on Fri Dec 15 16:30:53 GMT 2023
|
PRIMARY | |||
|
U-24
Created by
admin on Fri Dec 15 16:30:53 GMT 2023 , Edited by admin on Fri Dec 15 16:30:53 GMT 2023
|
PRIMARY | |||
|
6440686
Created by
admin on Fri Dec 15 16:30:53 GMT 2023 , Edited by admin on Fri Dec 15 16:30:53 GMT 2023
|
PRIMARY | |||
|
C66073
Created by
admin on Fri Dec 15 16:30:53 GMT 2023 , Edited by admin on Fri Dec 15 16:30:53 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
PARENT -> SALT/SOLVATE | |||
|
PARENT -> SALT/SOLVATE |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |