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Details

Stereochemistry ACHIRAL
Molecular Formula C23H29N3O2
Molecular Weight 379.4953
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OXYPERTINE

SMILES

COC1=CC2=C(C=C1OC)C(CCN3CCN(CC3)C4=CC=CC=C4)=C(C)N2

InChI

InChIKey=XCWPUUGSGHNIDZ-UHFFFAOYSA-N
InChI=1S/C23H29N3O2/c1-17-19(20-15-22(27-2)23(28-3)16-21(20)24-17)9-10-25-11-13-26(14-12-25)18-7-5-4-6-8-18/h4-8,15-16,24H,9-14H2,1-3H3

HIDE SMILES / InChI

Description

Oxypertine (Equipertine, Forit, Integrin, Lanturil, Lotawin, Opertil) is a neuroleptic drug and was originally introduced as a treatment for schizophrenia in the 1960s. Oxypertine is an indole derivative with general properties similar to those of the phenothiazine, chlorpromazine. It has been given by mouth in the treatment of various psychoses including schizophrenia, mania, and disturbed behaviour, and of severe anxiety. Like reserpine and tetrabenazine, oxypertine depletes catecholamines, though not serotonin, possibly underlying its neuroleptic efficacy. The molecular structure is strongly similar to solypertine and milipertine.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
54.0 nM [IC50]
210.0 nM [IC50]
25.0 nM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Primary
FORIT
Primary
FORIT

PubMed

Sample Use Guides

In Vivo Use Guide
Oxypertine 20 mg given orally as a nocturnal sedative and again on the morning of operation produced relief of anxiety
Route of Administration: Oral
In Vitro Use Guide
Oxypertine inhibited [3H]WB-4101 binding in rat cerebral cortex membranes with IC50 54 nM