Details
Stereochemistry | RACEMIC |
Molecular Formula | C13H19NO3 |
Molecular Weight | 237.2949 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC1=C(OCC2CNCCO2)C=CC=C1
InChI
InChIKey=YWPHCCPCQOJSGZ-UHFFFAOYSA-N
InChI=1S/C13H19NO3/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11/h3-6,11,14H,2,7-10H2,1H3
Viloxazine is an antidepressant drug was used to treat patients with depression. Viloxazine inhibits noradrenaline uptake. This drug was approved in some Europe countries, but not in the USA, but then it was discontinued because of competition from other drugs. In the frame of drug repositioning, Viloxazine participated in clinical trials for the treatment of attention deficit hyperactivity disorder. Phase II of trials was successfully passed.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: P23975 Gene ID: 6530.0 Gene Symbol: SLC6A2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/27230580 |
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Target ID: P23975 Gene ID: 6530.0 Gene Symbol: SLC6A2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/27230580 |
PubMed
Title | Date | PubMed |
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[Comparative evaluation of the therapeutic efficacy of the antidepressants adepren, linamiphen and emovit]. | 1986 |
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Clinical significance of pharmacokinetic interactions between antiepileptic and psychotropic drugs. | 2002 |
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Simultaneous determination of viloxazine, venlafaxine, imipramine, desipramine, sertraline, and amoxapine in whole blood: comparison of two extraction/cleanup procedures for capillary gas chromatography with nitrogen-phosphorus detection. | 2002 Jul-Aug |
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Contribution of sleep research to the development of new antidepressants. | 2005 |
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The AGNP-TDM Expert Group Consensus Guidelines: focus on therapeutic monitoring of antidepressants. | 2005 |
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Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis. | 2005 Dec 9 |
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Internet-based search of randomised trials relevant to mental health originating in the Arab world. | 2005 Jul 26 |
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Enhancing central noradrenergic function in depression: is there still a place for a new antidepressant? | 2005 Mar |
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[Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations]. | 2006 Jun |
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Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach. | 2006 Oct 20 |
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Comparison of electron and chemical ionization modes by validation of a quantitative gas chromatographic-mass spectrometric assay of new generation antidepressants and their active metabolites in plasma. | 2007 Dec 28 |
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Quantification of tricyclic antidepressants and monoamine oxidase inhibitors by high-performance liquid chromatography-tandem mass spectrometry in whole blood. | 2007 May |
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Adjustment Disorder: epidemiology, diagnosis and treatment. | 2009 Jun 26 |
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Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography-mass spectrometry. | 2009 Nov |
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Getting the balance right: Established and emerging therapies for major depressive disorders. | 2010 Sep 7 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22454923
100 mg
Route of Administration:
Oral
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WIKIPEDIA |
Designer-drugs-Viloxazine
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NCI_THESAURUS |
C265
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VILOXAZINE
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SUB00049MIG
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C152877
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ACTIVE MOIETY
METABOLITE (PARENT)
METABOLITE INACTIVE (PARENT)
SALT/SOLVATE (PARENT)