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Details

Stereochemistry RACEMIC
Molecular Formula C13H19NO3
Molecular Weight 237.2954
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VILOXAZINE

SMILES

CCOc1ccccc1OCC2CNCCO2

InChI

InChIKey=YWPHCCPCQOJSGZ-UHFFFAOYSA-N
InChI=1S/C13H19NO3/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11/h3-6,11,14H,2,7-10H2,1H3

HIDE SMILES / InChI
Viloxazine is an antidepressant drug was used to treat patients with depression. Viloxazine inhibits noradrenaline uptake. This drug was approved in some Europe countries, but not in the USA, but then it was discontinued because of competition from other drugs. In the frame of drug repositioning, Viloxazine participated in clinical trials for the treatment of attention deficit hyperactivity disorder. Phase II of trials was successfully passed.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P23975
Gene ID: 6530.0
Gene Symbol: SLC6A2
Target Organism: Homo sapiens (Human)
Target ID: P23975
Gene ID: 6530.0
Gene Symbol: SLC6A2
Target Organism: Homo sapiens (Human)
PubMed

PubMed

TitleDatePubMed
[Comparative evaluation of the therapeutic efficacy of the antidepressants adepren, linamiphen and emovit].
1986
Stereochemistry and drug efficacy and development: relevance of chirality to antidepressant and antipsychotic drugs.
2002
Simultaneous determination of viloxazine, venlafaxine, imipramine, desipramine, sertraline, and amoxapine in whole blood: comparison of two extraction/cleanup procedures for capillary gas chromatography with nitrogen-phosphorus detection.
2002 Jul-Aug
Contribution of sleep research to the development of new antidepressants.
2005
Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis.
2005 Dec 9
Internet-based search of randomised trials relevant to mental health originating in the Arab world.
2005 Jul 26
Gastrointestinal bleeding and massive liver damage in neuroleptic malignant syndrome.
2005 Sep
Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach.
2006 Oct 20
Comparison of electron and chemical ionization modes by validation of a quantitative gas chromatographic-mass spectrometric assay of new generation antidepressants and their active metabolites in plasma.
2007 Dec 28
Quantification of tricyclic antidepressants and monoamine oxidase inhibitors by high-performance liquid chromatography-tandem mass spectrometry in whole blood.
2007 May
Antidepressant drugs for narcolepsy.
2008 Jan 23
A prognostic system applicable to patients with resectable liver metastasis from colorectal carcinoma staged by positron emission tomography with [18F]fluoro-2-deoxy-D-glucose: role of primary tumor variables.
2008 May
Getting the balance right: Established and emerging therapies for major depressive disorders.
2010 Sep 7
Patents

Patents

Sample Use Guides

100 mg
Route of Administration: Oral
Name Type Language
VILOXAZINE
INN   MI   VANDF   WHO-DD  
INN  
Official Name English
VILOXAZINE [INN]
Common Name English
VILOXAZINE [WHO-DD]
Common Name English
VILOXAZINE [MI]
Common Name English
MORPHOLINE, 2-((2-ETHOXYPHENOXY)METHYL)-
Systematic Name English
(+/-)-2-(O-ETHOXYPHENOXYMETHYL)MORPHOLINE
Common Name English
VILOXAZIN
Common Name English
VILOXAZINE [VANDF]
Common Name English
Classification Tree Code System Code
WHO-ATC N06AX09
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
WHO-VATC QN06AX09
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
NCI_THESAURUS C265
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
Code System Code Type Description
FDA UNII
5I5Y2789ZF
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
MERCK INDEX
M11448
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY Merck Index
INN
3489
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
DRUG BANK
DB09185
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
ChEMBL
CHEMBL306700
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
WIKIPEDIA
VILOXAZINE
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
ECHA (EC/EINECS)
256-281-7
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
EPA CompTox
46817-91-8
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
MESH
D014745
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
CAS
46817-91-8
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
RXCUI
11196
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY RxNorm
DRUG CENTRAL
2820
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
PUBCHEM
5666
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
EVMPD
SUB00049MIG
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY
NCI_THESAURUS
C152877
Created by admin on Fri Jun 25 23:08:57 UTC 2021 , Edited by admin on Fri Jun 25 23:08:57 UTC 2021
PRIMARY