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Details

Stereochemistry ABSOLUTE
Molecular Formula C11H12Cl2N2O.ClH
Molecular Weight 295.593
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DEXLOFEXIDINE HYDROCHLORIDE

SMILES

Cl.C[C@H](OC1=C(Cl)C=CC=C1Cl)C2=NCCN2

InChI

InChIKey=DWWHMKBNNNZGHF-FJXQXJEOSA-N
InChI=1S/C11H12Cl2N2O.ClH/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13;/h2-4,7H,5-6H2,1H3,(H,14,15);1H/t7-;/m0./s1

HIDE SMILES / InChI

Description

Dexlofexidine is an isomer “+“ of lofexidine, which is agonist of alpha 2-adrenoceptor, but in 10 times less potent than the other isomer, levlofexidine.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Agonist
2678
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Interference of enantiomers of lofexidine with alpha-adrenoceptors.
1985 Jan
Patents

Patents

WO2006014484A2
134

Sample Use Guides

In Vivo Use Guide
in rats
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Name Type Language
DEXLOFEXIDINE HYDROCHLORIDE
Common Name English
1H-IMIDAZOLE, 2-((1S)-1-(2,6-DICHLOROPHENOXY)ETHYL)-4,5-DIHYDRO-, HYDROCHLORIDE (1:1)
Systematic Name English
LOFEXIDINE HYDROCHLORIDE, (+)-
Common Name English
LOFEXIDINE HYDROCHLORIDE, (S)-
Common Name English
1H-IMIDAZOLE, 2-(1-(2,6-DICHLOROPHENOXY)ETHYL)-4,5-DIHYDRO-, MONOHYDROCHLORIDE, (S)-
Common Name English
Code System Code Type Description
PUBCHEM
45279768
Created by admin on Sat Dec 16 11:11:38 GMT 2023 , Edited by admin on Sat Dec 16 11:11:38 GMT 2023
PRIMARY
FDA UNII
56H4BIV8OG
Created by admin on Sat Dec 16 11:11:38 GMT 2023 , Edited by admin on Sat Dec 16 11:11:38 GMT 2023
PRIMARY
CAS
87858-98-8
Created by admin on Sat Dec 16 11:11:38 GMT 2023 , Edited by admin on Sat Dec 16 11:11:38 GMT 2023
PRIMARY
PARENT (SALT/SOLVATE)
Structure of DEXLOFEXIDINE
NIH
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