ISOFLUPREDONE ACETATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H29FO6
Molecular Weight	420.4712
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@](O)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

InChIKey=ZOCUOMKMBMEYQV-GSLJADNHSA-N

InChI=1S/C23H29FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h6,8,10,16-18,27,29H,4-5,7,9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=155625

Isoflupredone is a veterinary drug used in cows, pigs and horses for the treatment of wide range of conditions: ketosis, musculoskeletal disorders, hypersensitivity, infections, inflammatory diseases, etc. The drug belongs to the class of corticosteroids and exerts its therapeutic effect by binding to glucocorticoid and mineralocorticoid receptors of animals.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Animal Glucocorticoid receptor 2 Target ID: Animal Glucocorticoid receptor Sources: http://www.merckvetmanual.com/mvm/pharmacology/anti-inflammatory_agents/corticosteroids.html	Binding Agent 1064
Animal Mineralocorticoid receptor 2 Target ID: Animal Mineralocorticoid receptor Sources: http://www.merckvetmanual.com/mvm/pharmacology/anti-inflammatory_agents/corticosteroids.html	Binding Agent 1064

Conditions

Condition	Modality	Highest Phase	Product
Bovine ketosis 2 Sources: https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=155625	Curative	Approved 8429	PREDEF Approved Use Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc. Launch Date 1959
Musculoskeletal conditions 6 Sources: https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=155625	Palliative	Approved 8429	PREDEF Approved Use Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc. Launch Date 1959
Allergic reactions 2 Sources: https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=155625	Primary	Approved 8429	PREDEF Approved Use Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc. Launch Date 1959
Infections 6 Sources: https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=155625	Curative	Approved 8429	PREDEF Approved Use Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc. Launch Date 1959
Shock 9 Sources: https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=155625	Palliative	Approved 8429	PREDEF Approved Use Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc. Launch Date 1959
Stress 11 Sources: https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=155625	Palliative	Approved 8429	PREDEF Approved Use Bovine Ketosis, Musculoskeletal Conditions, Allergic Reactions, Overwhelming Infections with Severe Toxicity, Shock, etc. Launch Date 1959

PubMed

Title	Date	PubMed
Hypertension and hypokalaemia caused by 9 alpha-fluoroprednisolone in a nasal spray.	1979 Jun 16	87768

Patents

Sample Use Guides

In Vivo Use Guide

The usual intramuscular dose for cattle is 10 to 20 mg, according to the size of the animal and severity of the condition. This dose may be repeated in 12 to 24 hours if indicated. The usual intramuscular dose for horses is 5 to 20 mg repeated as necessary. The usual intramuscular dose for swine is 5 mg for a 300 pound animal.

Route of Administration: Intramuscular

In Vitro Use Guide

Unknown

Name

Type

Language

ISOFLUPREDONE ACETATE

Official Name

English

NSC-12600

Code

English

ISOFLUPREDONE ACETATE [MART.]

Common Name

English

Isoflupredone acetate [WHO-DD]

Common Name

English

9-Fluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate

Systematic Name

English

NSC-37977

Code

English

ISOFLUPREDONE ACETATE [GREEN BOOK]

Common Name

English

ISOFLUPREDONE ACETATE [USP-RS]

Common Name

English

ISOFLUPREDONE 21-ACETATE

Common Name

English

ISOFLUPREDONE ACETATE [USP MONOGRAPH]

Common Name

English

ISOFLUPREDONE ACETATE [USAN]

Common Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 21-(ACETYLOXY)-9-FLUORO-11,17-DIHYDROXY-, (11.BETA.)-

Systematic Name

English

U-6013

Code

English

ISOFLUPREDONE 21-ACETATE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521