Details
Stereochemistry | ACHIRAL |
Molecular Formula | C15H25N2O.Cl |
Molecular Weight | 284.825 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=C(C)C=C1C
InChI
InChIKey=KOOGJYYOMPUGCW-UHFFFAOYSA-N
InChI=1S/C15H24N2O.ClH/c1-6-17(7-2)10-14(18)16-15-12(4)8-11(3)9-13(15)5;/h8-9H,6-7,10H2,1-5H3,(H,16,18);1H
Trimecaine is an amide series local anesthetic with antiarrhythmic activity. It was shown to be capable of eliminating the flutter of atria in dogs simulated by an electric stimulation of the myocardium and atrial fibrillation in cats induced with aconitin and precludes ventricular fibrillation in rats arising due to intoxication with calcium chloride. Trimecaine noticeably mitigates the toxic effect of strophanthin. While depressing the automatism of the sinoatrial node the drug does not affect the conduction function. The combination of epidural trimecaine with morphine after a major urological surgery provides a superior analgesia with fewer side effects when compared to epidurally delivered bupivacaine with fentanyl.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: GO:0006818 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2553153 |
PubMed
Title | Date | PubMed |
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[Comparative study of the activity of anti-arrhythmia agents in calcium chloride-induced arrhythmia in mice]. | 1983 May-Jun |
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[Some aspects of epidural anesthesia in patients with chronic renal insufficiency]. | 2001 Jul-Aug |
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[Magnetically-guided anesthetics based on highly dispersed iron powders coated by polyacrylamide]. | 2002 Mar-Apr |
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[Infiltration of local anesthetics into the thyroid gland capsule for surgery and the postoperative period]. | 2002 Oct |
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[Study of antiarrhythmic activity and duration of action of quaternidine]. | 2003 Sep-Oct |
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NCI_THESAURUS |
C245
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13932
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DTXSID5045702
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213-836-8
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1027-14-1
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SUB04967MIG
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5491FXS1NB
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100000092649
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C97300
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ACTIVE MOIETY
SUBSTANCE RECORD