Details
Stereochemistry | ACHIRAL |
Molecular Formula | C15H25N2O.Cl |
Molecular Weight | 284.825 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=C(C)C=C1C
InChI
InChIKey=KOOGJYYOMPUGCW-UHFFFAOYSA-N
InChI=1S/C15H24N2O.ClH/c1-6-17(7-2)10-14(18)16-15-12(4)8-11(3)9-13(15)5;/h8-9H,6-7,10H2,1-5H3,(H,16,18);1H
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C15H24N2O |
Molecular Weight | 248.3639 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Trimecaine is an amide series local anesthetic with antiarrhythmic activity. It was shown to be capable of eliminating the flutter of atria in dogs simulated by an electric stimulation of the myocardium and atrial fibrillation in cats induced with aconitin and precludes ventricular fibrillation in rats arising due to intoxication with calcium chloride. Trimecaine noticeably mitigates the toxic effect of strophanthin. While depressing the automatism of the sinoatrial node the drug does not affect the conduction function. The combination of epidural trimecaine with morphine after a major urological surgery provides a superior analgesia with fewer side effects when compared to epidurally delivered bupivacaine with fentanyl.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: GO:0006818 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2553153 |
PubMed
Title | Date | PubMed |
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[Complications after intravenous administration of anti-arrhythmia agents]. | 1982 Nov |
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[Magnetically-guided anesthetics based on highly dispersed iron powders coated by polyacrylamide]. | 2002 Mar-Apr |
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[Disarticulation of the knee joint]. | 2003 |
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[The antiarrhythmic activity of the trimecain ammonium derivative in myocardial ischemia]. | 2003 May-Jun |
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[Study of antiarrhythmic activity and duration of action of quaternidine]. | 2003 Sep-Oct |
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The epidural postoperative analgesia after a major urological procedures--a comparison of trimecaine and morphine to bupivacaine and fentanyl. | 2008 |
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Prenatal diagnosis and management of fetal Long QT syndrome. | 2009 Feb |
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Convergence of nasal and tracheal neural pathways in modulating the cough response in guinea pigs. | 2009 Jun |
|
[Detection of certain local anesthetics in biological fluids by chemo-toxicological analysis]. | 2009 May-Jun |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:47:57 GMT 2023
by
admin
on
Fri Dec 15 18:47:57 GMT 2023
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Record UNII |
5491FXS1NB
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Record Status |
Validated (UNII)
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Record Version |
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-
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NCI_THESAURUS |
C245
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SUB04967MIG
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5491FXS1NB
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100000092649
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C97300
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Related Record | Type | Details | ||
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ACTIVE MOIETY |