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Details

Stereochemistry RACEMIC
Molecular Formula C19H24N2O2.C7H8O3S
Molecular Weight 484.608
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of XYLAMIDINE TOSYLATE ANHYDROUS

SMILES

CC1=CC=C(C=C1)S(O)(=O)=O.COC2=CC(OC(C)CNC(=N)CC3=CC=CC(C)=C3)=CC=C2

InChI

InChIKey=FRJLUWKYXWADTA-UHFFFAOYSA-N
InChI=1S/C19H24N2O2.C7H8O3S/c1-14-6-4-7-16(10-14)11-19(20)21-13-15(2)23-18-9-5-8-17(12-18)22-3;1-6-2-4-7(5-3-6)11(8,9)10/h4-10,12,15H,11,13H2,1-3H3,(H2,20,21);2-5H,1H3,(H,8,9,10)

HIDE SMILES / InChI

Description

Xylamidine is a peripherally-restricted antagonist of 5HT2A and 5HT1A receptor. It is used to study the role of the serotonin receptors in the regulation of food intake, cardiovascular function, and regulation of body temperature.

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
5-HT activates vagal afferent cell bodies in vivo: role of 5-HT2 and 5-HT3 receptors.
2006-11-17
Differential effects of nitroblue tetrazolium on the hemodynamic responses elicited by activation of alpha1-adrenoceptors and 5-HT2 receptors in conscious rats.
2006-03-27
Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction.
2004-12-03
Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit.
2004-03
Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves nitric oxide and 5-HT2B receptor activation.
2003-03
Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms.
1991-12
Effects of xylamidine on peripheral 5-hydroxytryptamine-induced anorexia.
1989-12
Name Type Language
XYLAMIDINE TOSYLATE ANHYDROUS
Common Name English
XYLAMIDINE TOSILATE
INN  
INN  
Preferred Name English
XYLAMIDE TOSILATE
Common Name English
N-(2-(M-METHOXYPHENOXY)PROPYL)-2-M-TOLYLACETAMIDINE MONO-P-TOLUENESULFONATE
Common Name English
XYLAMIDINE TOSYLATE
USAN  
USAN  
Official Name English
XYLAMIDINE TOSYLATE [USAN]
Common Name English
XYLAMIDINE TOSILATE ANHYDROUS
Common Name English
xylamidine tosilate [INN]
Common Name English
N-(2-(M-METHOXYPHENOXY)PROPYL)-2-M-TOLYLACETAMIDINE MONO-P-TOLUENESULPHONATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C66885
Created by admin on Mon Mar 31 18:48:41 GMT 2025 , Edited by admin on Mon Mar 31 18:48:41 GMT 2025
Code System Code Type Description
NCI_THESAURUS
C152937
Created by admin on Mon Mar 31 18:48:41 GMT 2025 , Edited by admin on Mon Mar 31 18:48:41 GMT 2025
PRIMARY
ChEMBL
CHEMBL2110630
Created by admin on Mon Mar 31 18:48:41 GMT 2025 , Edited by admin on Mon Mar 31 18:48:41 GMT 2025
PRIMARY
INN
2313
Created by admin on Mon Mar 31 18:48:41 GMT 2025 , Edited by admin on Mon Mar 31 18:48:41 GMT 2025
PRIMARY
CAS
6443-40-9
Created by admin on Mon Mar 31 18:48:41 GMT 2025 , Edited by admin on Mon Mar 31 18:48:41 GMT 2025
PRIMARY
SMS_ID
100000079381
Created by admin on Mon Mar 31 18:48:41 GMT 2025 , Edited by admin on Mon Mar 31 18:48:41 GMT 2025
PRIMARY
FDA UNII
4ZF9UZ56C7
Created by admin on Mon Mar 31 18:48:41 GMT 2025 , Edited by admin on Mon Mar 31 18:48:41 GMT 2025
PRIMARY
EVMPD
SUB00119MIG
Created by admin on Mon Mar 31 18:48:41 GMT 2025 , Edited by admin on Mon Mar 31 18:48:41 GMT 2025
PRIMARY
EPA CompTox
DTXSID00983001
Created by admin on Mon Mar 31 18:48:41 GMT 2025 , Edited by admin on Mon Mar 31 18:48:41 GMT 2025
PRIMARY
PUBCHEM
22950
Created by admin on Mon Mar 31 18:48:41 GMT 2025 , Edited by admin on Mon Mar 31 18:48:41 GMT 2025
PRIMARY
ACTIVE MOIETY
Structure of XYLAMIDINE
NIH
NCATS
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