U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C12H11I3N2O4
Molecular Weight 627.9406
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IODAMIDE

SMILES

CC(=NCc1c(c(c(c(c1I)N=C(C)O)I)C(=O)O)I)O

InChI

InChIKey=VVDGWALACJEJKG-UHFFFAOYSA-N
InChI=1S/C12H11I3N2O4/c1-4(18)16-3-6-8(13)7(12(20)21)10(15)11(9(6)14)17-5(2)19/h3H2,1-2H3,(H,16,18)(H,17,19)(H,20,21)

HIDE SMILES / InChI
Iodamide is an ionic monomeric iodinated radiographic contrast medium. It was used in many procedures and may be given intravenously or by other routes, for example by instillation into the bladder or uterus; it has also been used for computed tomography. It is usually given as a 24 to 65% solution of the meglumine salt, or as a mixture of the sodium and meglumine salts; solutions of the sodium salt have also been used. Iodamide is no longer marketed in the US.

Originator

Curator's Comment:: In 1962 Bracco researchers develop the first original contrast agent from their in-house research, with reduced toxicity and high tolerability: iodamide.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
RENOVUE-65

Approved Use

Unknown

Launch Date

2.70172799E11
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
14.02 g × h/L
9.8 g single, intravenous
dose: 9.8 g
route of administration: Intravenous
experiment type: SINGLE
co-administered:
IODAMIDE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
2.58 g × h/L
24.75 g single, intravenous
dose: 24.75 g
route of administration: Intravenous
experiment type: SINGLE
co-administered:
IODAMIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
6.69 g × h/L
61.82 g single, intravenous
dose: 61.82 g
route of administration: Intravenous
experiment type: SINGLE
co-administered:
IODAMIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
16.4 h
9.8 g single, intravenous
dose: 9.8 g
route of administration: Intravenous
experiment type: SINGLE
co-administered:
IODAMIDE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
1.29 h
24.75 g single, intravenous
dose: 24.75 g
route of administration: Intravenous
experiment type: SINGLE
co-administered:
IODAMIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
1.02 h
61.82 g single, intravenous
dose: 61.82 g
route of administration: Intravenous
experiment type: SINGLE
co-administered:
IODAMIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
95%
24.75 g single, intravenous
dose: 24.75 g
route of administration: Intravenous
experiment type: SINGLE
co-administered:
IODAMIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
95%
61.82 g single, intravenous
dose: 61.82 g
route of administration: Intravenous
experiment type: SINGLE
co-administered:
IODAMIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
PubMed

PubMed

TitleDatePubMed
Comparative multiclinical studies of iodamide and diatrizoate in excretory urography.
1973 Jan
Contrast-enhanced voiding US for grading of reflux in adult patients prior to antireflux ureteral implantation.
2004 Oct
Effects of iodinated contrast media on endothelium: An in vitro study.
2007 Mar
Diagnostic image quality of hysterosalpingography: ionic versus non ionic water soluble iodinated contrast media.
2009 Jul

Sample Use Guides

24% or 65%
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Name Type Language
IODAMIDE
INN   MART.   MI   USAN   WHO-DD  
INN   USAN  
Official Name English
SH 926
Code English
SH-926
Code English
IODAMIDE [USAN]
Common Name English
IODAMIDE [INN]
Common Name English
IODAMIDE [WHO-DD]
Common Name English
IODAMIDE [MART.]
Common Name English
.ALPHA.,5-DIACETAMIDO-2,4,6-TRIIODO-M-TOLUIC ACID
Systematic Name English
IODAMIDE [MI]
Common Name English
BENZOIC ACID, 3-(ACETYLAMINO)-5-((ACETYLAMINO)METHYL)-2,4,6-TRIIODO-
Common Name English
UROMIRO
Brand Name English
JODOMIRON
Brand Name English
B-4130
Code English
UROMIRON
Brand Name English
Classification Tree Code System Code
NCI_THESAURUS C28500
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
WHO-ATC V08AA03
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
WHO-VATC QV08AA03
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
Code System Code Type Description
DRUG BANK
DB08948
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
PRIMARY
MERCK INDEX
M6325
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
PRIMARY Merck Index
WIKIPEDIA
IODAMIDE
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
PRIMARY
EPA CompTox
440-58-4
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
PRIMARY
INN
1922
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
PRIMARY
RXCUI
5928
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
PRIMARY RxNorm
ChEMBL
CHEMBL1201239
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
PRIMARY
PUBCHEM
3723
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
PRIMARY
NCI_THESAURUS
C65928
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
PRIMARY
MESH
D007451
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
PRIMARY
FDA UNII
4RII332O0R
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
PRIMARY
DRUG CENTRAL
1452
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
PRIMARY
EVMPD
SUB08210MIG
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
PRIMARY
ECHA (EC/EINECS)
207-125-1
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
PRIMARY
CAS
440-58-4
Created by admin on Sat Jun 26 01:18:20 UTC 2021 , Edited by admin on Sat Jun 26 01:18:20 UTC 2021
PRIMARY