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Details

Stereochemistry ABSOLUTE
Molecular Formula C12H11I3N2O4.C7H17NO5
Molecular Weight 823.1537
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IODAMIDE MEGLUMINE

SMILES

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CC(=O)NCC1=C(I)C(C(O)=O)=C(I)C(NC(C)=O)=C1I

InChI

InChIKey=UYIPQECISAQMIU-WZTVWXICSA-N
InChI=1S/C12H11I3N2O4.C7H17NO5/c1-4(18)16-3-6-8(13)7(12(20)21)10(15)11(9(6)14)17-5(2)19;1-8-2-4(10)6(12)7(13)5(11)3-9/h3H2,1-2H3,(H,16,18)(H,17,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1

HIDE SMILES / InChI

Molecular Formula C7H17NO5
Molecular Weight 195.2136
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula C12H11I3N2O4
Molecular Weight 627.9402
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Iodamide is an ionic monomeric iodinated radiographic contrast medium. It was used in many procedures and may be given intravenously or by other routes, for example by instillation into the bladder or uterus; it has also been used for computed tomography. It is usually given as a 24 to 65% solution of the meglumine salt, or as a mixture of the sodium and meglumine salts; solutions of the sodium salt have also been used. Iodamide is no longer marketed in the US.

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
RENOVUE-65

AUC

ValueDoseCo-administeredAnalytePopulation
14.02 g × h/L
9.8 g single, intravenous
IODAMIDE plasma
Homo sapiens
2.58 g × h/L
24.75 g single, intravenous
IODAMIDE plasma
Homo sapiens
6.69 g × h/L
61.82 g single, intravenous
IODAMIDE plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
16.4 h
9.8 g single, intravenous
IODAMIDE plasma
Homo sapiens
1.29 h
24.75 g single, intravenous
IODAMIDE plasma
Homo sapiens
1.02 h
61.82 g single, intravenous
IODAMIDE plasma
Homo sapiens

Funbound

ValueDoseCo-administeredAnalytePopulation
95%
24.75 g single, intravenous
IODAMIDE plasma
Homo sapiens
95%
61.82 g single, intravenous
IODAMIDE plasma
Homo sapiens

PubMed

Sample Use Guides

In Vivo Use Guide
24% or 65%
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
6X283535A3
Record Status Validated (UNII)
Record Version