IODAMIDE MEGLUMINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H11I3N2O4.C7H17NO5
Molecular Weight	823.1537
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CC(=O)NCC1=C(I)C(C(O)=O)=C(I)C(NC(C)=O)=C1I

InChI

InChIKey=UYIPQECISAQMIU-WZTVWXICSA-N

InChI=1S/C12H11I3N2O4.C7H17NO5/c1-4(18)16-3-6-8(13)7(12(20)21)10(15)11(9(6)14)17-5(2)19;1-8-2-4(10)6(12)7(13)5(11)3-9/h3H2,1-2H3,(H,16,18)(H,17,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1

HIDE SMILES / InChI

Molecular Formula	C7H17NO5
Molecular Weight	195.2136
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C12H11I3N2O4
Molecular Weight	627.9402
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.drugfuture.com/mt/meglumine-iodamide.pdf

Iodamide is an ionic monomeric iodinated radiographic contrast medium. It was used in many procedures and may be given intravenously or by other routes, for example by instillation into the bladder or uterus; it has also been used for computed tomography. It is usually given as a 24 to 65% solution of the meglumine salt, or as a mixture of the sodium and meglumine salts; solutions of the sodium salt have also been used. Iodamide is no longer marketed in the US.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Contrast agent 13 Sources: https://www.ndrugs.com/?s=renovue-65	Diagnostic		Approved 8429	RENOVUE-65 Approved Use Unknown Launch Date 1978

AUC

Value	Dose	Analyte	Population
14.02 g × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/338644	9.8 g single, intravenous dose: 9.8 g route of administration: Intravenous experiment type: SINGLE co-administered:	IODAMIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2.58 g × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/338644	24.75 g single, intravenous dose: 24.75 g route of administration: Intravenous experiment type: SINGLE co-administered:	IODAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
6.69 g × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/338644	61.82 g single, intravenous dose: 61.82 g route of administration: Intravenous experiment type: SINGLE co-administered:	IODAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
16.4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/338644	9.8 g single, intravenous dose: 9.8 g route of administration: Intravenous experiment type: SINGLE co-administered:	IODAMIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1.29 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/338644	24.75 g single, intravenous dose: 24.75 g route of administration: Intravenous experiment type: SINGLE co-administered:	IODAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
1.02 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/338644	61.82 g single, intravenous dose: 61.82 g route of administration: Intravenous experiment type: SINGLE co-administered:	IODAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
95% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/338644	24.75 g single, intravenous dose: 24.75 g route of administration: Intravenous experiment type: SINGLE co-administered:		IODAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
95% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/338644	61.82 g single, intravenous dose: 61.82 g route of administration: Intravenous experiment type: SINGLE co-administered:		IODAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:31703	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:31703
ZINC	ZINC000003830933	http://zinc15.docking.org/substances/ZINC000003830933

PubMed

Title	Date	PubMed
Comparative multiclinical studies of iodamide and diatrizoate in excretory urography.	1973 Jan	4566357
[The effect of diagnostic contrast media on the activity of lactate dehydrogenase in rat blood].	2002 Jul-Aug	12449078
Effects of iodinated contrast media on endothelium: An in vitro study.	2007 Mar	17113744
Diagnostic image quality of hysterosalpingography: ionic versus non ionic water soluble iodinated contrast media.	2009 Jul	21611058

Sample Use Guides

In Vivo Use Guide

24% or 65%

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:28:49 GMT 2023` Edited by `admin` on `Fri Dec 15 16:28:49 GMT 2023`
Record UNII	6X283535A3
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

IODAMIDE MEGLUMINE

Official Name

English

IODAMIDE MEGLUMINE [USAN]

Common Name

English

MEGLUMINE IODAMIDE

Common Name

English

CHOLOGRAFIN MEGLUMINE

Brand Name

English

IODAMIDE MEGLUMINE [VANDF]

Common Name

English

MEGLUMINE IODAMIDE [MART.]

Common Name

English

RENOVUE-65

Brand Name

English

.ALPHA.,5-DIACETAMIDO-2,4,6-TRIIODO-M-TOLUIC ACID COMPOUND WITH 1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL (1:1)

Common Name

English

IODAMIDE MEGLUMINE [ORANGE BOOK]

Common Name

English

BENZOIC ACID, 3-(ACETYLAMINO)-5-((ACETYLAMINO)METHYL)-2,4,6-TRIIODO-, COMPOUND WITH 1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL (1:1)

Common Name

English

IODAMIDE N-METHYL-D-GLUCAMINE SALT

Common Name

English

RENOVUE

Brand Name

English

IODAMIDE N-METHYL-D-GLUCAMINE SALT [MI]

Common Name

English

Iodamide meglumine [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28500