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Details

Stereochemistry ACHIRAL
Molecular Formula Tl
Molecular Weight 200.9708
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 1

SHOW SMILES / InChI
Structure of THALLOUS CATION TL-201

SMILES

[Tl+]

InChI

InChIKey=ZLUSCZLCHQSJRU-OIOBTWANSA-N
InChI=1S/Tl/q+1/i1-3

HIDE SMILES / InChI
Thallous chloride (also known as Thallium(I) chloride) is a chemical compound with the formula TlCl. Thallous Chloride Tl 201 Injection is a diagnostic radiopharmaceutical indicated for: Myocardial perfusion imaging with planar scintigraphy or single-photon emission computed tomography (SPECT) for the diagnosis of coronary artery disease by localization of: Non-reversible defects (myocardial infarction) which may have prognostic value regarding survival. Reversible defects (myocardial ischemia) when used in conjunction with exercise or pharmacologic stress. Localization of sites of parathyroid hyperactivity pre- and post-operatively in patients with elevated serum calcium and parathyroid hormone levels.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
THALLOUS CHLORIDE TL 201

Approved Use

Thallous Chloride TI 201 Injection may be useful in myocardial perfusion imaging using either planar or SPECT (Single Photon Computed Tomography) techniques for the diagnosis and localization of myocardial infarction. It may also have prognostic value regarding survival, when used in the clinically stable patient following the onset of symptoms of an acute myocardial infarction, to assess the site and size of the perfusion defect. Thallous Chloride TI 201 Injection may also be useful in conjunction with exercise stress testing as an adjunct in the diagnosis of ischemic heart disease (atherosclerotic coronary artery disease). It is usually not possible to differentiate recent from old myocardial infarction, or to differentiate between recent myocardial infarction and ischemia. Thallous Chloride TI 201 Injection is indicated also for the localization of sites of parathyroid hyperactivity in patients with elevated serum calcium and parathyroid hormone levels. It may also be useful in pre-operative screening to localize extrathyroidal and mediastinal sites of parathyroid hyperactivity and for postsurgical reexamination. Thallous Chloride Tl 201 Injection has not been adequately demonstrated to be effective for the localization of normal parathyroid glands.

Launch Date

2.50992001E11
Diagnostic
THALLOUS CHLORIDE TL 201

Approved Use

Thallous Chloride TI 201 Injection may be useful in myocardial perfusion imaging using either planar or SPECT (Single Photon Computed Tomography) techniques for the diagnosis and localization of myocardial infarction. It may also have prognostic value regarding survival, when used in the clinically stable patient following the onset of symptoms of an acute myocardial infarction, to assess the site and size of the perfusion defect. Thallous Chloride TI 201 Injection may also be useful in conjunction with exercise stress testing as an adjunct in the diagnosis of ischemic heart disease (atherosclerotic coronary artery disease). It is usually not possible to differentiate recent from old myocardial infarction, or to differentiate between recent myocardial infarction and ischemia. Thallous Chloride TI 201 Injection is indicated also for the localization of sites of parathyroid hyperactivity in patients with elevated serum calcium and parathyroid hormone levels. It may also be useful in pre-operative screening to localize extrathyroidal and mediastinal sites of parathyroid hyperactivity and for postsurgical reexamination. Thallous Chloride Tl 201 Injection has not been adequately demonstrated to be effective for the localization of normal parathyroid glands.

Launch Date

2.50905592E11
PubMed

PubMed

TitleDatePubMed

Sample Use Guides

Recommended Dose Myocardial perfusion Planar scintigraphy: 37 to 74 MBq (1 to 2 mCi) administered intravenously SPECT: 74 to 111 MBq (2 to 3 mCi) administered intravenously Parathyroid hyperactivity localization Planar or SPECT: 75 to 130 MBq (2 to 3.5 mCi) administered intravenously
Route of Administration: Intravenous
Name Type Language
THALLOUS CATION TL-201
Common Name English
THALLIUM CATION TL-201
Common Name English
THALLOUS ION TL-201
Common Name English
THALLIUM CATION TL-201 (1+)
Common Name English
Classification Tree Code System Code
NDF-RT N0000177914
Created by admin on Fri Jun 25 22:43:42 UTC 2021 , Edited by admin on Fri Jun 25 22:43:42 UTC 2021
NDF-RT N0000000205
Created by admin on Fri Jun 25 22:43:42 UTC 2021 , Edited by admin on Fri Jun 25 22:43:42 UTC 2021
Code System Code Type Description
RXCUI
1546370
Created by admin on Fri Jun 25 22:43:42 UTC 2021 , Edited by admin on Fri Jun 25 22:43:42 UTC 2021
PRIMARY
FDA UNII
4877X14G4C
Created by admin on Fri Jun 25 22:43:42 UTC 2021 , Edited by admin on Fri Jun 25 22:43:42 UTC 2021
PRIMARY
PUBCHEM
10130399
Created by admin on Fri Jun 25 22:43:42 UTC 2021 , Edited by admin on Fri Jun 25 22:43:42 UTC 2021
PRIMARY
RXCUI
1546430
Created by admin on Fri Jun 25 22:43:42 UTC 2021 , Edited by admin on Fri Jun 25 22:43:42 UTC 2021
ALTERNATIVE
DRUG BANK
DB14576
Created by admin on Fri Jun 25 22:43:42 UTC 2021 , Edited by admin on Fri Jun 25 22:43:42 UTC 2021
PRIMARY