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Details

Stereochemistry ACHIRAL
Molecular Formula Cl.Tl
Molecular Weight 236.424
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THALLOUS CHLORIDE TL-201

SMILES

[Cl-].[201Tl+]

InChI

InChIKey=GBECUEIQVRDUKB-RYDPDVNUSA-M
InChI=1S/ClH.Tl/h1H;/q;+1/p-1/i;1-3

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Tl
Molecular Weight 200.9708
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Thallous chloride (also known as Thallium(I) chloride) is a chemical compound with the formula TlCl. Thallous Chloride Tl 201 Injection is a diagnostic radiopharmaceutical indicated for: Myocardial perfusion imaging with planar scintigraphy or single-photon emission computed tomography (SPECT) for the diagnosis of coronary artery disease by localization of: Non-reversible defects (myocardial infarction) which may have prognostic value regarding survival. Reversible defects (myocardial ischemia) when used in conjunction with exercise or pharmacologic stress. Localization of sites of parathyroid hyperactivity pre- and post-operatively in patients with elevated serum calcium and parathyroid hormone levels.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
THALLOUS CHLORIDE TL 201

Approved Use

Thallous Chloride TI 201 Injection may be useful in myocardial perfusion imaging using either planar or SPECT (Single Photon Computed Tomography) techniques for the diagnosis and localization of myocardial infarction. It may also have prognostic value regarding survival, when used in the clinically stable patient following the onset of symptoms of an acute myocardial infarction, to assess the site and size of the perfusion defect. Thallous Chloride TI 201 Injection may also be useful in conjunction with exercise stress testing as an adjunct in the diagnosis of ischemic heart disease (atherosclerotic coronary artery disease). It is usually not possible to differentiate recent from old myocardial infarction, or to differentiate between recent myocardial infarction and ischemia. Thallous Chloride TI 201 Injection is indicated also for the localization of sites of parathyroid hyperactivity in patients with elevated serum calcium and parathyroid hormone levels. It may also be useful in pre-operative screening to localize extrathyroidal and mediastinal sites of parathyroid hyperactivity and for postsurgical reexamination. Thallous Chloride Tl 201 Injection has not been adequately demonstrated to be effective for the localization of normal parathyroid glands.

Launch Date

2.50992001E11
Diagnostic
THALLOUS CHLORIDE TL 201

Approved Use

Thallous Chloride TI 201 Injection may be useful in myocardial perfusion imaging using either planar or SPECT (Single Photon Computed Tomography) techniques for the diagnosis and localization of myocardial infarction. It may also have prognostic value regarding survival, when used in the clinically stable patient following the onset of symptoms of an acute myocardial infarction, to assess the site and size of the perfusion defect. Thallous Chloride TI 201 Injection may also be useful in conjunction with exercise stress testing as an adjunct in the diagnosis of ischemic heart disease (atherosclerotic coronary artery disease). It is usually not possible to differentiate recent from old myocardial infarction, or to differentiate between recent myocardial infarction and ischemia. Thallous Chloride TI 201 Injection is indicated also for the localization of sites of parathyroid hyperactivity in patients with elevated serum calcium and parathyroid hormone levels. It may also be useful in pre-operative screening to localize extrathyroidal and mediastinal sites of parathyroid hyperactivity and for postsurgical reexamination. Thallous Chloride Tl 201 Injection has not been adequately demonstrated to be effective for the localization of normal parathyroid glands.

Launch Date

2.50905592E11
PubMed

PubMed

TitleDatePubMed
Thallium-201 for medical use. I.
1975 Feb

Sample Use Guides

Recommended Dose Myocardial perfusion Planar scintigraphy: 37 to 74 MBq (1 to 2 mCi) administered intravenously SPECT: 74 to 111 MBq (2 to 3 mCi) administered intravenously Parathyroid hyperactivity localization Planar or SPECT: 75 to 130 MBq (2 to 3.5 mCi) administered intravenously
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:46:06 UTC 2023
Edited
by admin
on Fri Dec 15 15:46:06 UTC 2023
Record UNII
3I8Y076A0E
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
THALLOUS CHLORIDE TL-201
ORANGE BOOK  
Common Name English
THALLOUS CHLORIDE (201 TL)
WHO-DD  
Common Name English
THALLIUM CHLORIDE, TL-201
Common Name English
THALLOUS CHLORIDE, TL-201
Common Name English
THALLOUS CHLORIDE (201-TL)
Common Name English
THALLOUS CHLORIDE TL 201 [USP IMPURITY]
Common Name English
THALLIUM CHLORIDE ((SUP 201)TLCL).
Common Name English
THALLOUS CHLORIDE TL 201 [USAN]
Common Name English
THALLOUS CHLORIDE TL-201 [ORANGE BOOK]
Common Name English
THALLOUS CHLORIDE TL 201
USAN   USP  
USAN  
Official Name English
THALLIUM CHLORIDE TL-201
Common Name English
THALLIUM (201TL) CHLORIDE [JAN]
Common Name English
Thallium (201Tl) chloride [WHO-DD]
Common Name English
THALLOUS CHLORIDE TL201
Common Name English
THALLOUS CHLORIDE,TL-201 [VANDF]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1446
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
NDF-RT N0000177914
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
WHO-ATC V09GX01
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
WHO-VATC QV09GX01
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
Code System Code Type Description
EVMPD
SUB23306
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
PRIMARY
SMS_ID
100000092757
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
PRIMARY
DRUG CENTRAL
5095
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
PRIMARY
LACTMED
Thallous Chloride Tl 201
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
PRIMARY
DAILYMED
3I8Y076A0E
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
PRIMARY
FDA UNII
3I8Y076A0E
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
PRIMARY
CAS
55172-29-7
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
PRIMARY
EVMPD
SUB127145
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
ALTERNATIVE
ChEMBL
CHEMBL2110567
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
PRIMARY
EPA CompTox
DTXSID301027509
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
PRIMARY
NCI_THESAURUS
C47750
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
PRIMARY
RXCUI
91588
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
PRIMARY RxNorm
PUBCHEM
72170
Created by admin on Fri Dec 15 15:46:06 UTC 2023 , Edited by admin on Fri Dec 15 15:46:06 UTC 2023
PRIMARY
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PARENT -> SALT/SOLVATE
NON-LABELED -> LABELED
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ACTIVE MOIETY