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Details

Stereochemistry ACHIRAL
Molecular Formula C5H10NS2.Tl
Molecular Weight 349.24
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THALLOUS DIETHYLDITHIOCARBAMATE TL-201

SMILES

[201Tl+].CCN(CC)C([S-])=S

InChI

InChIKey=DZDXQECBERXVDV-RYDPDVNUSA-M
InChI=1S/C5H11NS2.Tl/c1-3-6(4-2)5(7)8;/h3-4H2,1-2H3,(H,7,8);/q;+1/p-1/i;1-3

HIDE SMILES / InChI

Molecular Formula C5H11NS2
Molecular Weight 149.278
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Tl
Molecular Weight 200.9708
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Thallous chloride (also known as Thallium(I) chloride) is a chemical compound with the formula TlCl. Thallous Chloride Tl 201 Injection is a diagnostic radiopharmaceutical indicated for: Myocardial perfusion imaging with planar scintigraphy or single-photon emission computed tomography (SPECT) for the diagnosis of coronary artery disease by localization of: Non-reversible defects (myocardial infarction) which may have prognostic value regarding survival. Reversible defects (myocardial ischemia) when used in conjunction with exercise or pharmacologic stress. Localization of sites of parathyroid hyperactivity pre- and post-operatively in patients with elevated serum calcium and parathyroid hormone levels.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
THALLOUS CHLORIDE TL 201

Approved Use

Thallous Chloride TI 201 Injection may be useful in myocardial perfusion imaging using either planar or SPECT (Single Photon Computed Tomography) techniques for the diagnosis and localization of myocardial infarction. It may also have prognostic value regarding survival, when used in the clinically stable patient following the onset of symptoms of an acute myocardial infarction, to assess the site and size of the perfusion defect. Thallous Chloride TI 201 Injection may also be useful in conjunction with exercise stress testing as an adjunct in the diagnosis of ischemic heart disease (atherosclerotic coronary artery disease). It is usually not possible to differentiate recent from old myocardial infarction, or to differentiate between recent myocardial infarction and ischemia. Thallous Chloride TI 201 Injection is indicated also for the localization of sites of parathyroid hyperactivity in patients with elevated serum calcium and parathyroid hormone levels. It may also be useful in pre-operative screening to localize extrathyroidal and mediastinal sites of parathyroid hyperactivity and for postsurgical reexamination. Thallous Chloride Tl 201 Injection has not been adequately demonstrated to be effective for the localization of normal parathyroid glands.

Launch Date

2.50992001E11
Diagnostic
THALLOUS CHLORIDE TL 201

Approved Use

Thallous Chloride TI 201 Injection may be useful in myocardial perfusion imaging using either planar or SPECT (Single Photon Computed Tomography) techniques for the diagnosis and localization of myocardial infarction. It may also have prognostic value regarding survival, when used in the clinically stable patient following the onset of symptoms of an acute myocardial infarction, to assess the site and size of the perfusion defect. Thallous Chloride TI 201 Injection may also be useful in conjunction with exercise stress testing as an adjunct in the diagnosis of ischemic heart disease (atherosclerotic coronary artery disease). It is usually not possible to differentiate recent from old myocardial infarction, or to differentiate between recent myocardial infarction and ischemia. Thallous Chloride TI 201 Injection is indicated also for the localization of sites of parathyroid hyperactivity in patients with elevated serum calcium and parathyroid hormone levels. It may also be useful in pre-operative screening to localize extrathyroidal and mediastinal sites of parathyroid hyperactivity and for postsurgical reexamination. Thallous Chloride Tl 201 Injection has not been adequately demonstrated to be effective for the localization of normal parathyroid glands.

Launch Date

2.50905592E11
PubMed

PubMed

TitleDatePubMed

Sample Use Guides

Recommended Dose Myocardial perfusion Planar scintigraphy: 37 to 74 MBq (1 to 2 mCi) administered intravenously SPECT: 74 to 111 MBq (2 to 3 mCi) administered intravenously Parathyroid hyperactivity localization Planar or SPECT: 75 to 130 MBq (2 to 3.5 mCi) administered intravenously
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Fri Dec 15 14:58:01 UTC 2023
Edited
by admin
on Fri Dec 15 14:58:01 UTC 2023
Record UNII
3O488IB3CJ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
THALLOUS DIETHYLDITHIOCARBAMATE TL-201
Common Name English
THALLOUS DIETHYLDITHIOCARBAMATE, TL-201
Common Name English
THALLIUM-201TL, (DIETHYLCARBAMODITHIOATO-S,S')-
Systematic Name English
Code System Code Type Description
FDA UNII
3O488IB3CJ
Created by admin on Fri Dec 15 14:58:01 UTC 2023 , Edited by admin on Fri Dec 15 14:58:01 UTC 2023
PRIMARY
PUBCHEM
76958570
Created by admin on Fri Dec 15 14:58:01 UTC 2023 , Edited by admin on Fri Dec 15 14:58:01 UTC 2023
PRIMARY
CAS
141216-71-9
Created by admin on Fri Dec 15 14:58:01 UTC 2023 , Edited by admin on Fri Dec 15 14:58:01 UTC 2023
PRIMARY
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