NAPROXEN, (-)-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C14H14O3
Molecular Weight	230.2592
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

COC1=CC2=CC=C(C=C2C=C1)[C@@H](C)C(O)=O

InChI

InChIKey=CMWTZPSULFXXJA-SECBINFHSA-N

InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m1/s1

HIDE SMILES / InChI

Description

(R)-Naproxen is an enantiomer of the more active (S)-Naproxen, the last belongs to the class of Non-Steroidal Anti-Inflammatory Drugs. (S)- and (R)-naproxen represent useful substrates to distinguish different glucuronosyl transferases isozymes.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
UDP-glucuronosyltransferase 1-1 15	Substrate 661

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2,578

PubMed

Show entries

Title	Date	PubMed
Simultaneous determination of (R)- and (S)-naproxen and (R)- and (S)-6-O-desmethylnaproxen by high-performance liquid chromatography on a Chiral-AGP column.	1992 Jun 10	1400768
Methotrexate-induced optic neuropathy.	2002 Dec	12427239

Showing 1 to 2 of 2 entries

Previous1Next

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Show entries

Name

Type

Language

NAPROXEN, (-)-

Common Name

English

NAPROXEN IMPURITY G [EP IMPURITY]

Common Name

English

L-NAPROXEN

Common Name

English

NAPROXEN SODIUM IMPURITY G [EP IMPURITY]

Common Name

English

2-NAPHTHALENEACETIC ACID, 6-METHOXY-.ALPHA.-METHYL-, (.ALPHA.R)-

Systematic Name

English

Showing 1 to 5 of 10 entries

Previous1 2Next

Show entries

Code System

Code

Type

Description

ECHA (EC/EINECS)

245-966-6

PRIMARY

CAS

23979-41-1

PRIMARY

RS_ITEM_NUM

1457436

PRIMARY

PUBCHEM

169118

PRIMARY

EPA CompTox

DTXSID00904711

PRIMARY

Showing 1 to 5 of 6 entries

Previous1 2Next

SUBSTANCE RECORD


					484XV9323P

NAPROXEN, (-)-