U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C14H14O3
Molecular Weight 230.2592
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NAPROXEN, (-)-

SMILES

COC1=CC2=CC=C(C=C2C=C1)[C@@H](C)C(O)=O

InChI

InChIKey=CMWTZPSULFXXJA-SECBINFHSA-N
InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m1/s1

HIDE SMILES / InChI
(R)-Naproxen is an enantiomer of the more active (S)-Naproxen, the last belongs to the class of Non-Steroidal Anti-Inflammatory Drugs. (S)- and (R)-naproxen represent useful substrates to distinguish different glucuronosyl transferases isozymes.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Stereoselective (S)- and (R)-naproxen glucuronosyl transferases of rat liver.
1991 Mar-Apr
Simultaneous determination of (R)- and (S)-naproxen and (R)- and (S)-6-O-desmethylnaproxen by high-performance liquid chromatography on a Chiral-AGP column.
1992 Jun 10
Enantiomeric separation of R,S-naproxen by conventional and nano-liquid chromatography with methyl-beta-cyclodextrin as a mobile phase additive.
2001 Jul 27
Methotrexate-induced optic neuropathy.
2002 Dec
Occurrence and behavior of the chiral anti-inflammatory drug naproxen in an aquatic environment.
2014 Dec
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
NAPROXEN, (-)-
Common Name English
NAPROXEN IMPURITY G [EP IMPURITY]
Common Name English
L-NAPROXEN
Common Name English
NAPROXEN SODIUM IMPURITY G [EP IMPURITY]
Common Name English
2-NAPHTHALENEACETIC ACID, 6-METHOXY-.ALPHA.-METHYL-, (.ALPHA.R)-
Systematic Name English
(R)-(-)-NAPROXEN
Common Name English
NAPROXEN RELATED COMPOUND G [USP-RS]
Common Name English
(2R)-2-(6-METHOXYNAPHTHALEN-2-YL)PROPANOIC ACID
Systematic Name English
(-)-6-METHOXY-.ALPHA.-METHYL-2-NAPHTHALENEACETIC ACID
Systematic Name English
(R)-NAPROXEN
Common Name English
Code System Code Type Description
ECHA (EC/EINECS)
245-966-6
Created by admin on Sat Dec 16 08:34:59 GMT 2023 , Edited by admin on Sat Dec 16 08:34:59 GMT 2023
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CAS
23979-41-1
Created by admin on Sat Dec 16 08:34:59 GMT 2023 , Edited by admin on Sat Dec 16 08:34:59 GMT 2023
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RS_ITEM_NUM
1457436
Created by admin on Sat Dec 16 08:34:59 GMT 2023 , Edited by admin on Sat Dec 16 08:34:59 GMT 2023
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PUBCHEM
169118
Created by admin on Sat Dec 16 08:34:59 GMT 2023 , Edited by admin on Sat Dec 16 08:34:59 GMT 2023
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EPA CompTox
DTXSID00904711
Created by admin on Sat Dec 16 08:34:59 GMT 2023 , Edited by admin on Sat Dec 16 08:34:59 GMT 2023
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FDA UNII
484XV9323P
Created by admin on Sat Dec 16 08:34:59 GMT 2023 , Edited by admin on Sat Dec 16 08:34:59 GMT 2023
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