Details
Stereochemistry | RACEMIC |
Molecular Formula | C21H27NO3S2.ClH |
Molecular Weight | 442.035 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CN1C2CCC(C)(C)C1CC(C2)OC(=O)C(O)(C3=CC=CS3)C4=CC=CS4
InChI
InChIKey=KOYYWMFYAIFCBI-UHFFFAOYSA-N
InChI=1S/C21H27NO3S2.ClH/c1-20(2)9-8-14-12-15(13-16(20)22(14)3)25-19(23)21(24,17-6-4-10-26-17)18-7-5-11-27-18;/h4-7,10-11,14-16,24H,8-9,12-13H2,1-3H3;1H
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/4996373Curator's Comment: description was created based on several sources, including, https://www.ncbi.nlm.nih.gov/pubmed/5000167,
https://medical.mt-pharma.co.jp/di/file/dc/pnt.htm
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4996373
Curator's Comment: description was created based on several sources, including, https://www.ncbi.nlm.nih.gov/pubmed/5000167,
https://medical.mt-pharma.co.jp/di/file/dc/pnt.htm
Mazaticol is an anti-acetylcholine agent used in Japan for the treatment of Parkinson's syndrome.
CNS Activity
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Pharmacology of a new anti-parkinsonian drug: KAO-264. | 1971 Apr |
|
[Pharmacological properties of 6,6,9-trimethyl-9-azabicyclo (3,3,1)non-3 beta-yl-alpha, alpha-di(2-thienyl) glycolate hydrochloride monohydrate (PG-501), a new anti-parkinsonian agent]. | 1971 Jul |
|
Metabolic fate of 6,6,9-trimethyl-9-azabicyclo(3,3,1)non-3 -yl , -di(2-thienyl)glycolate hydrochloride monohydrate (PG-501). | 1972 Aug |
|
[Absorption, distribution and excretion of 14 C-labelled 6,6,9-trimethyl-9-azabicyclo(3,3,1)non-3 -yl a,a-di(2-thienyl)glycolate hydrochloride monohydrate (PG-501)]. | 1972 Aug |
|
Computerized EEG study on drug-induced extrapyramidalism in schizophrenic patients. | 1982 |
|
Effects of anticholinergic antiparkinsonian drugs on binding of muscarinic receptor subtypes in rat brain. | 1990 Sep |
|
Population pharmacokinetics of haloperidol using routine clinical pharmacokinetic data in Japanese patients. | 2002 |
Sample Use Guides
In Vivo Use Guide
Sources: https://medical.mt-pharma.co.jp/di/file/dc/pnt.htm
1 tablet (4 mg) is administered orally three times a day. In case of taking Pentona 1%, 0.4 g should be administered the same way.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5000167
Curator's Comment: the full-text can be found here: https://www.jstage.jst.go.jp/article/fpj1944/67/4/67_4_387/_pdf
Anti-acetylcholine activity of mazaticol on he isolated guinea-pig ileum preparation was studied in vitro. ED50 value was 6.4*10(-9) g/ml.
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44WQI5180Q
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100000086161
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SUB03096MIG
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32891-29-5
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135004
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CHEMBL2105187
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ACTIVE MOIETY
SUBSTANCE RECORD