U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C9H11NO3
Molecular Weight 181.1889
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TYROSINE

SMILES

c1cc(ccc1C[C@@]([H])(C(=O)O)N)O

InChI

InChIKey=OUYCCCASQSFEME-QMMMGPOBSA-N
InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1

HIDE SMILES / InChI
Tyrosine (L-form) is a non-essential amino acid, which is primarily required for the protein synthesis. This amino acid is the precursor of dopamine, norepinephrine, and epinephrine; therefore the lower concentration of tyrosine could be a peripheral marker of the hyperdopaminergic condition hypothesized to explain psychosis. Tyrosine supplements can improve cognition, increase energy, reduce anxiety, reduce depression, reduce levels of pain.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
AMINOSYN

Approved Use

Aminosyn, Sulfite-Free, (a crystalline amino acid solution) infused with dextrose by peripheral vein infusion is indicated as a source of nitrogen in the nutritional support of patients with adequate stores of body fat, in whom, for short periods of time, oral nutrition cannot be tolerated, is undesirable, or inadequate.

Launch Date

1.86796802E11
PubMed

PubMed

TitleDatePubMed
Identification of receptor tyrosine kinase associating proteins using the yeast two-hybrid system.
2001
Identification of receptor tyrosine kinase (RTK) substrates by the cloning of receptor targets (CORT) strategy.
2001
Cloning protein tyrosine kinases by screening cDNA libraries with antiphosphotyrosine antibodies.
2001
Synthesis and use of DNA containing a 5'-bridging phosphorothioate as a suicide substrate for type I DNA topoisomerases.
2001
Receptors, second messengers and protein kinases required for heterosynaptic cerebellar long-term depression.
2001
The Src kinase p56(lck) up-regulates VLA-4 integrin affinity. Implications for rapid spontaneous and chemokine-triggered T cell adhesion to VCAM-1 and fibronectin.
2001 Apr 27
The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.
2001 Feb 16
Glycosylation-induced conformational modification positively regulates receptor-receptor association: a study with an aberrant epidermal growth factor receptor (EGFRvIII/DeltaEGFR) expressed in cancer cells.
2001 Feb 16
Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation.
2001 Feb 16
Phosphatidic acid regulates tyrosine phosphorylating activity in human neutrophils: enhancement of Fgr activity.
2001 Feb 16
Identification of residues in the N-terminal domain of the Yersinia tyrosine phosphatase that are critical for substrate recognition.
2001 Feb 16
The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction.
2001 Feb 16
Integrin-independent tyrosine phosphorylation of p125(fak) in human platelets stimulated by collagen.
2001 Feb 2
Activation of Rho is required for ligand-independent oncogenic signaling by a mutant epidermal growth factor receptor.
2001 Feb 2
Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin.
2001 Feb 2
The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton.
2001 Feb 23
T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4.
2001 Feb 23
Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway.
2001 Feb 23
alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases.
2001 Feb 9
Multiple C-terminal motifs of the 46-kDa mannose 6-phosphate receptor tail contribute to efficient binding of medium chains of AP-2 and AP-3.
2001 Feb 9
Biochemical and immunohistological changes in the brain of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse.
2001 Jan
Phosphatidylinositol-3 kinase acts in parallel to the ERK MAP kinase in the FGF pathway during Xenopus mesoderm induction.
2001 Jan
Noninvasive assessment of aromatic L-amino acid decarboxylase activity in aging rhesus monkey brain in vivo.
2001 Jan
Regulation of GAP-43 protein and mRNA in nigrostriatal dopaminergic neurons after the partial destruction of dopaminergic terminals with intrastriatal 6-hydroxydopamine.
2001 Jan
Characterization of a prostate-specific tyrosine phosphatase by mutagenesis and expression in human prostate cancer cells.
2001 Jan 26
EPR studies of the water oxidizing complex in the S1 and the higher S states: the manganese cluster and Y(Z) radical.
2001 Jan 5
EPR/ENDOR characterization of the physical and electronic structure of the OEC Mn cluster.
2001 Jan 5
Vibrational spectroscopy of the oxygen-evolving complex and of manganese model compounds.
2001 Jan 5
Metallo-radical hypothesis for photoassembly of (Mn)4-cluster of photosynthetic oxygen evolving complex.
2001 Jan 5
Okadaic acid-induced upregulation of nitrotyrosine and heme oxygenase-1 in rat cortical neuron cultures.
2001 Jan 5
Effects of tumor necrosis factor alpha on taurine uptake in cultured rat astrocytes.
2001 Mar
Essential tyrosine residues for interaction of the non-receptor protein-tyrosine phosphatase PTP1B with N-cadherin.
2001 Mar 2
Multiple regions of MAP kinase phosphatase 3 are involved in its recognition and activation by ERK2.
2001 Mar 2
Insufficient phosphorylation prevents fc gamma RIIB from recruiting the SH2 domain-containing protein-tyrosine phosphatase SHP-1.
2001 Mar 2
Altered regulation of cell cycle machinery involved in interleukin-1-induced G(1) and G(2) phase growth arrest of A375S2 human melanoma cells.
2001 Mar 2
Fibrin clot retraction by human platelets correlates with alpha(IIb)beta(3) integrin-dependent protein tyrosine dephosphorylation.
2001 Mar 2
ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks.
2001 Mar 23
Cloning of ACP33 as a novel intracellular ligand of CD4.
2001 Mar 23
Contrasting localizations of MALS/LIN-7 PDZ proteins in brain and molecular compensation in knockout mice.
2001 Mar 23
Functional relationships between capacitation-dependent cell signaling and compartmentalized metabolic pathways in murine spermatozoa.
2001 Mar 9
PU.1 is a lineage-specific regulator of tyrosine phosphatase CD45.
2001 Mar 9
Regulation of ROMK1 channels by protein-tyrosine kinase and -tyrosine phosphatase.
2001 Mar 9
An interaction between ricin and calreticulin that may have implications for toxin trafficking.
2001 Mar 9
Stimulation of extracellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone is protein kinase C-dependent.
2001 Mar 9
Inhibition of osteoclast function by adenovirus expressing antisense protein-tyrosine kinase 2.
2001 Mar 9
The basis of prostaglandin synthesis in coral: molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosa.
2001 Mar 9
Mechanism of stimulation of osteoclastic bone resorption through Gas6/Tyro 3, a receptor tyrosine kinase signaling, in mouse osteoclasts.
2001 Mar 9
CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration.
2001 Mar 9
The two major plant plasma membrane H+-ATPases display different regulatory properties.
2001 Mar 9
Borna disease virus persistent infection activates mitogen-activated protein kinase and blocks neuronal differentiation of PC12 cells.
2001 Mar 9
Patents

Sample Use Guides

In adults, tyrosine (Aminosyn solution) is given for nutritional maintenance via peripheral vein at a final amino acid concentration of 3.5, 4.25 or 5% together with dextrose in concentrations of 5% to 10%. 5%, 7%, 8.5% and 10% solutions should only be infused via a central vein when admixed with sufficient dextrose. In pediatric patients, the amino acid mixture is administered in a 2.5% concentration.
Route of Administration: Intravenous
In Vitro Use Guide
Human melanoma cell line IIB-MEL-J was treated with 3 mM tyrosine. The amino acid produced a great decrease in the cell growth rate, a loss of the anchor-age-independent growth capacity, and a change in the morphology of the cells to a fibroblastoid aspect.
Name Type Language
TYROSINE
EP   HSDB   II   INCI   INN   MART.   MI   ORANGE BOOK   USAN   USP   VANDF   WHO-DD  
INCI   USAN   INN  
Official Name English
TYROSINE [ORANGE BOOK]
Common Name English
L-TYROSINE
FCC   FHFI   JAN   USP-RS  
Systematic Name English
LEVODOPA RELATED COMPOUND L-TYROSINE [USP]
Common Name English
TYROSINE [MART.]
Common Name English
TYROSINE [USAN]
Common Name English
FEMA NO. 3736
Code English
TYROSINE [INN]
Common Name English
TYROSINE [WHO-DD]
Common Name English
TYROSINE [EP MONOGRAPH]
Common Name English
LEVODOPA IMPURITY, L-TYROSINE- [USP]
Common Name English
TYROSINE [II]
Common Name English
LEVODOPA SPECIFIED IMPURITY B [EP]
Common Name English
(2S)-2-AMINO-3-(4-HYDROXYPHENYL)PROPANOIC ACID
Common Name English
L-TYROSINE [FHFI]
Common Name English
TYROSINE [HSDB]
Common Name English
TYROSINE [INCI]
Common Name English
L-TYROSINE [USP-RS]
Common Name English
L-TYROSINE [FCC]
Common Name English
L-TYROSINE [JAN]
Common Name English
TYROSINE [USP]
Common Name English
(-)-.ALPHA.-AMINO-P-HYDROXYHYDROCINNAMIC ACID
Common Name English
TYROSINE, L-
Systematic Name English
TYROSINE [MI]
Common Name English
TYROSINE [VANDF]
Common Name English
2-AMINO-3-(4-HYDROXYPHENYL)PROPANOIC ACID, (S)-
Common Name English
NSC-82624
Code English
Classification Tree Code System Code
LOINC 47795-0
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JECFA EVALUATION L-TYROSINE
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LOINC 21057-5
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LOINC 32265-1
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DSLD 251 (Number of products:239)
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LOINC 27361-5
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LOINC 35571-9
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LOINC 21056-7
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LOINC 41170-2
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LOINC 25996-0
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CFR 21 CFR 172.320
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LOINC 3077-5
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LOINC 53393-5
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DSLD 1540 (Number of products:1613)
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LOINC 56994-7
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LOINC 3080-9
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LOINC 13417-1
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NCI_THESAURUS C68442
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LOINC 25547-1
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LOINC 22739-7
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LOINC 30054-1
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LOINC 3079-1
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LOINC 2768-0
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LOINC 30069-9
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NCI_THESAURUS C29596
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LOINC 22642-3
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Code System Code Type Description
DRUG BANK
DB00135
Created by admin on Fri Jun 25 21:11:09 UTC 2021 , Edited by admin on Fri Jun 25 21:11:09 UTC 2021
PRIMARY
USP_CATALOG
1705006
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PRIMARY USP-RS
EVMPD
SUB11371MIG
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PRIMARY
EVMPD
SUB21993
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PRIMARY
HSDB
2003
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PRIMARY
NCI_THESAURUS
C915
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PRIMARY
RXCUI
10962
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PRIMARY RxNorm
DRUG CENTRAL
2786
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PRIMARY
WIKIPEDIA
TYROSINE
Created by admin on Fri Jun 25 21:11:09 UTC 2021 , Edited by admin on Fri Jun 25 21:11:09 UTC 2021
PRIMARY
ECHA (EC/EINECS)
200-460-4
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PRIMARY
CAS
60-18-4
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PRIMARY
MESH
D014443
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PRIMARY
PUBCHEM
6057
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PRIMARY
EPA CompTox
60-18-4
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PRIMARY
FDA UNII
42HK56048U
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PRIMARY
MERCK INDEX
M11290
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PRIMARY Merck Index
INN
6174
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PRIMARY
ChEMBL
CHEMBL925
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PRIMARY