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Details

Stereochemistry ABSOLUTE
Molecular Formula C9H11NO3
Molecular Weight 181.1885
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TYROSINE

SMILES

N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

InChI

InChIKey=OUYCCCASQSFEME-QMMMGPOBSA-N
InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1

HIDE SMILES / InChI

Description

Tyrosine (L-form) is a non-essential amino acid, which is primarily required for the protein synthesis. This amino acid is the precursor of dopamine, norepinephrine, and epinephrine; therefore the lower concentration of tyrosine could be a peripheral marker of the hyperdopaminergic condition hypothesized to explain psychosis. Tyrosine supplements can improve cognition, increase energy, reduce anxiety, reduce depression, reduce levels of pain.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
AMINOSYN

Cmax

ValueDoseCo-administeredAnalytePopulation
154 nmol/mL
100 mg/kg single, oral
TYROSINE plasma
Homo sapiens
203 nmol/mL
150 mg/kg single, oral
TYROSINE plasma
Homo sapiens

OverviewOther

Other InhibitorOther SubstrateOther Inducer




Drug as perpetrator​

Drug as victim

Tox targets

PubMed

Sample Use Guides

In Vivo Use Guide
In adults, tyrosine (Aminosyn solution) is given for nutritional maintenance via peripheral vein at a final amino acid concentration of 3.5, 4.25 or 5% together with dextrose in concentrations of 5% to 10%. 5%, 7%, 8.5% and 10% solutions should only be infused via a central vein when admixed with sufficient dextrose. In pediatric patients, the amino acid mixture is administered in a 2.5% concentration.
Route of Administration: Intravenous
In Vitro Use Guide
Human melanoma cell line IIB-MEL-J was treated with 3 mM tyrosine. The amino acid produced a great decrease in the cell growth rate, a loss of the anchor-age-independent growth capacity, and a change in the morphology of the cells to a fibroblastoid aspect.