U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C18H25NO
Molecular Weight 277.4342
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DEUDEXTROMETHORPHAN

SMILES

[H][C@]12CCCC[C@]13CCN([C@H]2CC4=CC=C(OC([2H])([2H])[2H])C=C34)C([2H])([2H])[2H]

InChI

InChIKey=MKXZASYAUGDDCJ-QNNIAVNKSA-N
InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1/i1D3,2D3

HIDE SMILES / InChI
Dextromethorphan D6 is a weak uncompetitive antagonist of the NMDA receptor. Dextromethorphan is also acts at nicotinic receptors, sigma-1 rcptor and serotonin and norepinephrine transporters. The incorporation of deuterium serves to reduce dextromethorphan first-pass liver metabolism. AVP-786 is an oral formulation of a combination of deuterated (d6)-dextromethorphan and an ultra-low dose of quinidine. Avanir Pharmaceuticals launched a phase III development program of AVP-786 for the treatment of agitation in patients with Alzheimer's disease.

Approval Year

Name Type Language
DEUDEXTROMETHORPHAN
INN   USAN   WHO-DD  
USAN   INN  
Official Name English
DEUDEXTROMETHORPHAN [USAN]
Common Name English
D6-DM
Common Name English
deudextromethorphan [INN]
Common Name English
(+)-3-D3-METHOXY-17-D3-METHYL-(9.ALPHA.,13.ALPHA.,14.ALPHA.)-MORPHINAN
Common Name English
MORPHINAN, 3-(METHOXY-D3)-17-(METHYL-D3)-, (9.ALPHA.,13.ALPHA.,14.ALPHA.)-
Systematic Name English
DEXTROMETHORPHAN D6
Common Name English
D6-DEXTROMETHORPHAN
Common Name English
Deudextromethorphan [WHO-DD]
Common Name English
C10003
Code English
C-10003
Code English
CTP-786
Code English
Code System Code Type Description
RXCUI
2569466
Created by admin on Sat Dec 16 09:45:14 GMT 2023 , Edited by admin on Sat Dec 16 09:45:14 GMT 2023
PRIMARY
SMS_ID
100000176367
Created by admin on Sat Dec 16 09:45:14 GMT 2023 , Edited by admin on Sat Dec 16 09:45:14 GMT 2023
PRIMARY
USAN
DE-127
Created by admin on Sat Dec 16 09:45:14 GMT 2023 , Edited by admin on Sat Dec 16 09:45:14 GMT 2023
PRIMARY
NCI_THESAURUS
C166711
Created by admin on Sat Dec 16 09:45:14 GMT 2023 , Edited by admin on Sat Dec 16 09:45:14 GMT 2023
PRIMARY
INN
10288
Created by admin on Sat Dec 16 09:45:14 GMT 2023 , Edited by admin on Sat Dec 16 09:45:14 GMT 2023
PRIMARY
FDA UNII
427476LZFT
Created by admin on Sat Dec 16 09:45:14 GMT 2023 , Edited by admin on Sat Dec 16 09:45:14 GMT 2023
PRIMARY
PUBCHEM
25052519
Created by admin on Sat Dec 16 09:45:14 GMT 2023 , Edited by admin on Sat Dec 16 09:45:14 GMT 2023
PRIMARY
CAS
1079043-55-2
Created by admin on Sat Dec 16 09:45:14 GMT 2023 , Edited by admin on Sat Dec 16 09:45:14 GMT 2023
PRIMARY