Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H25NO |
| Molecular Weight | 277.4342 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12CCCC[C@]13CCN([C@H]2CC4=CC=C(OC([2H])([2H])[2H])C=C34)C([2H])([2H])[2H]
InChI
InChIKey=MKXZASYAUGDDCJ-QNNIAVNKSA-N
InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1/i1D3,2D3
Dextromethorphan D6 is a weak uncompetitive antagonist of the NMDA receptor. Dextromethorphan is also acts at nicotinic receptors, sigma-1 rcptor and serotonin and norepinephrine transporters. The incorporation of deuterium serves to reduce dextromethorphan first-pass liver metabolism. AVP-786 is an oral formulation of a combination of deuterated (d6)-dextromethorphan and an ultra-low dose of quinidine. Avanir Pharmaceuticals launched a phase III development program of AVP-786 for the treatment of agitation in patients with Alzheimer's disease.
Approval Year
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| Code System | Code | Type | Description | ||
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2569466
Created by
admin on Sat Dec 16 09:45:14 GMT 2023 , Edited by admin on Sat Dec 16 09:45:14 GMT 2023
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100000176367
Created by
admin on Sat Dec 16 09:45:14 GMT 2023 , Edited by admin on Sat Dec 16 09:45:14 GMT 2023
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DE-127
Created by
admin on Sat Dec 16 09:45:14 GMT 2023 , Edited by admin on Sat Dec 16 09:45:14 GMT 2023
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C166711
Created by
admin on Sat Dec 16 09:45:14 GMT 2023 , Edited by admin on Sat Dec 16 09:45:14 GMT 2023
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10288
Created by
admin on Sat Dec 16 09:45:14 GMT 2023 , Edited by admin on Sat Dec 16 09:45:14 GMT 2023
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427476LZFT
Created by
admin on Sat Dec 16 09:45:14 GMT 2023 , Edited by admin on Sat Dec 16 09:45:14 GMT 2023
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25052519
Created by
admin on Sat Dec 16 09:45:14 GMT 2023 , Edited by admin on Sat Dec 16 09:45:14 GMT 2023
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1079043-55-2
Created by
admin on Sat Dec 16 09:45:14 GMT 2023 , Edited by admin on Sat Dec 16 09:45:14 GMT 2023
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PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)
