Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H28FO8P.2Na |
| Molecular Weight | 516.4046 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 9 / 9 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].[H][C@@]12C[C@@H](C)[C@](O)(C(=O)COP([O-])([O-])=O)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C
InChI
InChIKey=MHQJKNHAJIVSPW-ZDKQYMEBSA-L
InChI=1S/C22H30FO8P.2Na/c1-11-6-14-13-8-16(23)15-7-12(24)4-5-20(15,2)19(13)17(25)9-21(14,3)22(11,27)18(26)10-31-32(28,29)30;;/h4-5,7,11,13-14,16-17,19,25,27H,6,8-10H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t11-,13+,14+,16+,17+,19-,20+,21+,22+;;/m1../s1
Paramethasone is a glucocorticoid. It exerts anti-inflammatory and immunosuppressant actions. Paramethasone stimulates the synthesis of enzymes needed to decrease anti-inflammatory response. It suppresses the immune system by reducing activity and volume of the lymphatic system, thus producing lymphocytopenia decreasing passage of immune complexes and possibly by depressing reactivity of tissue to antigen-antibody interactions.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pseudo-allergic reactions to corticosteroids: diagnosis and alternatives. | 1995 May-Jun |
|
| Two cases of specific adverse reactions to systemic corticosteroids. | 1996 Sep-Oct |
|
| [Chronic adhesive arachnoiditis following epidural paramethasone]. | 1997 Dec |
|
| Surgical decompression versus local steroid injection in carpal tunnel syndrome: a one-year, prospective, randomized, open, controlled clinical trial. | 2005 Feb |
|
| Tachon's syndrome (suracute back and/or thoracic pain following local injections of corticosteroids). A report of 318 French cases. | 2005 Jan |
|
| [Hiccups crisis following paramethasone intraarticular injection]. | 2005 Jun 25 |
|
| Epidural dextran-40 and paramethasone injection for treatment of spontaneous intracranial hypotension. | 2006 Jun |
|
| Adalimumab for the treatment of fistulas in patients with Crohn's disease. | 2009 Jul |
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SUB03646MIG
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218-410-5
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DTXSID10944042
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2145-14-4
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100000085518
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16509
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41I31208JK
Created by
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ACTIVE MOIETY
SUBSTANCE RECORD
