PARAMETHASONE DISODIUM PHOSPHATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H28FO8P.2Na
Molecular Weight	516.4046
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PARAMETHASONE DISODIUM PHOSPHATE

Structure Search

SMILES

[Na+].[Na+].C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP([O-])([O-])=O

InChI

InChIKey=MHQJKNHAJIVSPW-ZDKQYMEBSA-L

InChI=1S/C22H30FO8P.2Na/c1-11-6-14-13-8-16(23)15-7-12(24)4-5-20(15,2)19(13)17(25)9-21(14,3)22(11,27)18(26)10-31-32(28,29)30;;/h4-5,7,11,13-14,16-17,19,25,27H,6,8-10H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t11-,13+,14+,16+,17+,19-,20+,21+,22+;;/m1../s1

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C22H28FO8P
Molecular Weight	470.4251
Charge	-2
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	9 / 9
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.drugs.com/international/paramethasone.html | https://www.ncbi.nlm.nih.gov/pubmed/839089 | https://books.google.ru/books?id=ihxyHbnj3qYC&printsec=frontcover&hl=ru#v=onepage&q&f=false

Paramethasone is a glucocorticoid. It exerts anti-inflammatory and immunosuppressant actions. Paramethasone stimulates the synthesis of enzymes needed to decrease anti-inflammatory response. It suppresses the immune system by reducing activity and volume of the lymphatic system, thus producing lymphocytopenia decreasing passage of immune complexes and possibly by depressing reactivity of tissue to antigen-antibody interactions.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
inflammatory response 47 Target ID: GO:0006954 Sources: Ebadi, M. (2007) Desk Reference of Clinical Pharmacology, page 543, retrieved from: https://books.google.ru/books?id=ihxyHbnj3qYC	Modulator 846

PubMed

Title	Date	PubMed
Adalimumab for the treatment of fistulas in patients with Crohn's disease.	2009-07	19201775
Epidural dextran-40 and paramethasone injection for treatment of spontaneous intracranial hypotension.	2006-06	16738294
[Hiccups crisis following paramethasone intraarticular injection].	2005-06-25	15989860
Surgical decompression versus local steroid injection in carpal tunnel syndrome: a one-year, prospective, randomized, open, controlled clinical trial.	2005-02	15692981
Tachon's syndrome (suracute back and/or thoracic pain following local injections of corticosteroids). A report of 318 French cases.	2005-01	15681251
[Chronic adhesive arachnoiditis following epidural paramethasone].	1997-12	9528075
Two cases of specific adverse reactions to systemic corticosteroids.	1996-09-01	8959545
Pseudo-allergic reactions to corticosteroids: diagnosis and alternatives.	1995-05-01	7582165

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:32:37 GMT 2025` Edited by `admin` on `Mon Mar 31 21:32:37 GMT 2025`
Record UNII	41I31208JK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PREGNA-1,4-DIENE-3,20-DIONE, 6-FLUORO-11,17-DIHYDROXY-16-METHYL-21-(PHOSPHONOOXY)-, DISODIUM SALT, (6.ALPHA.,11.BETA.,16.ALPHA.)-

Preferred Name

English

PARAMETHASONE DISODIUM PHOSPHATE

Common Name

English

Paramethasone disodium phosphate [WHO-DD]

Common Name

English

Code System Code Type Description

EVMPD

SUB03646MIG