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Description
Curator's Comment: description was created based on several sources, including: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5176be07-3121-49fb-9eb9-638903753a31 | https://www.drugs.com/monograph/atracurium-besylate.html | http://www.wikidoc.org/index.php/Atracurium

Atracurium is an intermediate-duration, nondepolarizing, skeletal muscle relaxant for intravenous administration. It is used, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Most adverse reactions were suggestive of histamine release. Common side effects include flushing of the skin and low blood pressure. Drugs which may enhance the neuromuscular blocking action of atracurium include: enflurane; isoflurane; halothane; certain antibiotics, especially the aminoglycosides and polymyxins; lithium; magnesium salts; procainamide; and quinidine.

CNS Activity

Originator

Approval Year

1983
81
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
 169.5 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8429
ATRACURIUM BESYLATE

Approved Use

Atracurium Besylate Injection, USP is indicated, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Launch Date

1997
PubMed

PubMed

TitleDatePubMed
Synthesis and structure-activity relationships of neuromuscular blocking agents.
2002 Aug
[Relaxation and the electromyographic identification of the recurrent laryngeal nerve].
2002 Sep
[Interaction of donepezil and muscular blockers in Alzheimer's disease].
2003 Feb
A comparison of the efficacy of cisatracurium and atracurium in kidney transplantation operation.
2004 Jan
[Establishment of a hypothermic dog model to investigate airway rewarming].
2006 Aug
Dynamic encoding of natural luminance sequences by LGN bursts.
2006 Jul
Timing precision in population coding of natural scenes in the early visual system.
2008 Dec 16
Leaking abdominal aortic aneurysm on anticoagulants-thromboelastography assisted management.
2009 Jun
A prospective randomized double blind study to evaluate the effect of infusion of amino Acid enriched solution on recovery from neuromuscular blockade.
2009 Jun
Modulation of temporal precision in thalamic population responses to natural visual stimuli.
2010
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Comparison between Culture Conditions Improving Growth and Differentiation of Blood and Bone Marrow Cells Committed to the Endothelial Cell Lineage.
2010 Feb 6
Marfan syndrome with acute abdomen: a case report.
2010 Nov 10
Cisatracurium in different doses versus atracurium during general anesthesia for abdominal surgery.
2010 Sep
Wound contraction and macro-deformation during negative pressure therapy of sternotomy wounds.
2010 Sep 30
Patents

Patents

DE 2655883
2
US 4179507
2

Sample Use Guides

In Vivo Use Guide
An atracurium besylate dose of 0.4 to 0.5 mg/kg (1.7 to 2.2 times the ED95), given as an intravenous bolus injection, is the recommended initial dose for most patients. Maximum neuromuscular block achieved approximately 3 to 5 minutes after injection.
Route of Administration: Intravenous
In Vitro Use Guide
Exposure of isolated rat hepatocytes to atracurium produced cellular damage evidenced by extrusion of an intracellular enzyme, lactate dehydrogenase (LDH), into the incubation medium. Leakage of LDH was directly related to the concentration of atracurium in the medium (250 to 800 microM). When atracurium was added to the medium and the medium immediately added to hepatocytes, the leakage of LDH increased as the concentration of atracurium increased (P < 0.001 for the comparison with cells not exposed to atracurium).
Name Type Language
ATRACURIUM BESYLATE
MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF  
USAN  
Official Name English
ISOQUINOLINIUM, 2,2'-(1,5-PENTANEDIYLBIS(OXY(3-OXO-3,1-PROPANEDIYL)))BIS(1-((3,4-DIMETHOXYPHENYL)METHYL)-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYL-, (1R,2R,1'R,2'R)- BISBENZENESULFONATE
Common Name English
NSC-760047
Code English
(1R,2R,1'R,2'R)-2,2'-(PENTANE-1,5-DIYLBIS(OXY(3-OXOPROPANE-3,1-DIYL)))BIS(1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXY-2-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINIUM) BISBENZENESULFONATE
Common Name English
ATRACURIUM BESYLATE [MI]
Common Name English
ATRACURIUM BESILATE
EP   INN   MART.   WHO-DD  
INN  
Official Name English
ATRACURIUM BESYLATE [USAN]
Common Name English
TRACRIUM
Brand Name English
ATRACURIUM BESYLATE [VANDF]
Common Name English
ATRACURIUM BESYLATE [USP-RS]
Common Name English
atracurium besilate [INN]
Common Name English
2-(2-Carboxyethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium benzenesulfonate, pentamethylene ester
Common Name English
BW-33A
Code English
ATRACURIUM DIBESYLATE
Common Name English
WELLCOME 33-A-74
Code English
ATRACURIUM BESYLATE [ORANGE BOOK]
Common Name English
BW 33A
Code English
ATRACURIUM BESILATE [MART.]
Common Name English
Atracurium besilate [WHO-DD]
Common Name English
ATRACURIUM BESYLATE [USP MONOGRAPH]
Common Name English
ATRACURIUM BESILATE [EP MONOGRAPH]
Common Name English
ISOQUINOLINIUM, 2,2'-(1,5-PENTANEDIYLBIS(OXY(3-OXO-3,1-PROPANEDIYL)))BIS(1-((3,4-DIMETHOXYPHENYL)METHYL)-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYL-, DIBENZENESULFONATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29696
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
Code System Code Type Description
INN
4734
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
EVMPD
SUB05603MIG
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
ECHA (EC/EINECS)
264-743-4
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
DRUG BANK
DB00732
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
RXCUI
1219
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY RxNorm
NCI_THESAURUS
C28839
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
ChEMBL
CHEMBL1360
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
NSC
760047
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
EPA CompTox
DTXSID6022630
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
CAS
64228-81-5
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
MERCK INDEX
m2129
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY Merck Index
FDA UNII
40AX66P76P
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
WIKIPEDIA
ATRACURIUM BESILATE
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
RS_ITEM_NUM
1044800
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
CHEBI
2915
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
USAN
T-90
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
DAILYMED
40AX66P76P
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
All of the following components must be present:
Structure of ATRACURIUM BESYLATE, (1S,2R,1'S,2'R)-(±)-
Structure of ATRACURIUM BESYLATE, (1R,2R,1'S,2'S)-
Structure of ATRACURIUM BESYLATE, (1R,2R,1'R,2'S)-(±)-
Structure of ATRACURIUM BESYLATE, (1R,2R,1'S,2'R)-(±)-
Structure of ATRACURIUM BESYLATE, (1R,1'R,2R,2'R)-(±)-
Structure of ATRACURIUM BESYLATE, (1R,2S,1'S,2'R)-
ACTIVE MOIETY
ATRACURIUM
SUBSTANCE RECORD
ATRACURIUM BESYLATE
Definition References
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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