U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C42H62O16.H3N
Molecular Weight 839.9626
Optical Activity UNSPECIFIED
Defined Stereocenters 19 / 19
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMMONIUM GLYCYRRHIZATE

SMILES

N.[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]3(C)C2=CC(=O)[C@]4([H])[C@@]5(C)CC[C@H](O[C@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O[C@@H]7O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)C(O)=O)C(O)=O)C(C)(C)[C@]5([H])CC[C@@]34C)C(O)=O

InChI

InChIKey=ILRKKHJEINIICQ-OOFFSTKBSA-N
InChI=1S/C42H62O16.H3N/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54);1H3/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+;/m0./s1

HIDE SMILES / InChI

Description

Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair care, skin care, shaving, personal hygiene and suntan products.

Approval Year

1921
1,467

Targets

Primary TargetPharmacologyConditionPotency
reactive oxygen species metabolic process
68
Modulator
828
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
17
Activator
1,430
Alanine aminotransferase 1
17
Inhibitor
8,297

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inflammation
102
 Primary
Basic research
Unknown
Erythema
17
 Primary
Phase I
428
Unknown
Cardiomyopathy
21
 Primary
Preclinical
Unknown
Autoimmune hepatitis
17
 Primary
Phase I
428
Unknown
Chronic hepatitis C
42
 Palliative
Approved
8,429
Stronger Neo-Minophagen C
Radiodermatitis
16
 Preventing
Basic research
MASO65D (Xclair®)
Ovarian cancer
157
 Primary
Basic research
Unknown
Hepatitis B
57
 Palliative
Not Provided
504
Unknown
Autoimmune hepatitis
17
 Palliative
Phase I
428
Unknown
Chronic hepatitis C
42
 Palliative
Not Provided
504
Unknown

PubMed

Patents

CN105237609A
16
EP0409005A2
16
EP0472858A2
16
EP2628487A1
16
JP06298668
16
JP2000063254A
16
JP2000143518A
26
JP2000247885A
20
JP2000290199A
28
JP2000512663A
47
JP2001039853A
16
JP2003335651A
17
JP2005220084A
17
JP2007022923A
16
JP2008115109A
16
JP2008222682A
16
JPH0296533A
16
JPH03123465A
16
JPH0315397A
16
JPH03161423A
16
JPH0399023A
26
JPH04207200A
16
JPH0436215A
16
JPH06199648A
16
JPH06279265A
16
JPH07118140A
16
JPH07291857A
16
JPH0748595A
16
JPH09110675A
20
JPH10316555A
16
JPH11139951A
16
JPH11199426A
16
JPS06183145A
16
JPS06251604A
16
JPS06335515A
16
JPS59227812A
20
JPS60260540A
16
JPS61155315A
16
JPS63135351A
16
US20080161377
16
US20110015143
16
US20130143830
16
US20150147357
16
US3164581
16
US5186945
16
US5372744
16
WO2009115455A1
16

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Topical
In Vitro Use Guide
Glycyrrhetinic acid (ENOXOLONE) could inhibit CYP3A4 activity competitively, with a Ki value of 1.57 μM in human liver microsomes.
ACTIVE MOIETY
Structure of ENOXOLONE
PARENT (SALT/SOLVATE)
Structure of GLYCYRRHIZIN
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966